Tuberc Respir Dis.  2002 Dec;53(6):595-611. 10.4046/trd.2002.53.6.595.

Molecular Mechanisms of Neutrophil Activation in Acute Lung Injury

• Yum HK

• KMID: 1877035
• DOI: http://doi.org/10.4046/trd.2002.53.6.595

Abstract

ABBREVIATIONS: Akt/PKB protein kinase B, ALI acute lung injury, ARDS acute respiratory distress syndrome, CREB C-AMP response element binding protein, ERK extracelluar signal-related kinase, fMLP fMet-Leu-Phe, G-CSF granulocyte colony-stimulating factor, IL interleukin, ILK integrin-linked kinase, JNK Jun N-terminal kinase, LPS lipopolysaccharide, MAP mitogen-activated protein, MEK MAP/ERK kinase, MIP-2 macrophage inflammatory protein-2, MMP matrix metalloproteinase, MPO myeloperoxidase, NADPH nicotinamide adenine dinucleotide phosphate, NE neutrophil elastase, NF-kappaB nuclear factor-kappa B, NOS nitric oxide synthase, p38 MAPK p38 mitogen activated protein kinase, PAF platelet activating factor, PAKs p21-activated kinases, PMN polymorphonuclear leukocytes, PI3-K phosphatidylinositol 3-kinase, PyK proline-rich tyrosine kinase, ROS reactive oxygen species, TNF-alpha tumor necrosis factor-alpha.

Keyword

Acute lung injury; Neutrophil; Signal transduction

MeSH Terms

Abbreviations
Acute Lung Injury*
Carrier Proteins
Granulocyte Colony-Stimulating Factor
Interleukins
Leukocyte Elastase
Macrophages
N-Formylmethionine Leucyl-Phenylalanine
NADP
Neutrophil Activation*
Neutrophils*
NF-kappa B
Nitric Oxide Synthase
p21-Activated Kinases
p38 Mitogen-Activated Protein Kinases
Peroxidase
Phosphatidylinositol 3-Kinase
Phosphotransferases
Platelet Activating Factor
Protein Kinases
Protein-Tyrosine Kinases
Proto-Oncogene Proteins c-akt
Reactive Oxygen Species
Respiratory Distress Syndrome, Adult
Response Elements
Signal Transduction
Tumor Necrosis Factor-alpha
Carrier Proteins
Granulocyte Colony-Stimulating Factor
Interleukins
Leukocyte Elastase
N-Formylmethionine Leucyl-Phenylalanine
NADP
NF-kappa B
Nitric Oxide Synthase
Peroxidase
Phosphatidylinositol 3-Kinase
Phosphotransferases
Platelet Activating Factor
Protein Kinases
Protein-Tyrosine Kinases
Proto-Oncogene Proteins c-akt
Reactive Oxygen Species
Tumor Necrosis Factor-alpha
p21-Activated Kinases
p38 Mitogen-Activated Protein Kinases