- Phosphatidylinositol-3-kinase Inhibitor Enhances Nitric Oxide Synthesis and Apoptosis in LPS-Stimulated Macrophages
-
Park YC
- KMID: 1610767
- Korean J Anat.
- 2003 Aug;36(4):323-329.
Phosphatidylinositol-3-kinase (PI3-kinase) is critical player in cell proliferation and death. The mechanism by which bacterial lipopolysaccharide (LPS) induces synthesis of nitric oxide (NO) in murine macrophages is incompletely understood. In... -
- CITED
-
- Close
- SHARE
-
- Close
- The role of PI3K/AKT pathway and its therapeutic possibility in Alzheimer's disease
-
Yu HJ, Koh SH
- KMID: 2384003
- Hanyang Med Rev.
- 2017 May;37(1):18-24.
- doi: 10.7599/hmr.2017.37.1.18
Alzheimer's disease (AD) is the most common form of dementia. Although uncountable clinical trials have been done to develop the treatment of AD, there are a couple of drugs that... -
- CITED
-
- Close
- SHARE
-
- Close
- The Role of Phosphatase and Tensin Homolog Deleted on Chromosome Ten (PTEN) in Lung Cancer
-
Lee HK, Lee YC
- KMID: 2325380
- J Lung Cancer.
- 2004 Mar;3(1):1-5.
Lung cancer remains the primary cause of cancer-related death in the world, and the number of cases continues to increase. Like any other human cancer, the development of lung cancer... -
- CITED
-
- Close
- SHARE
-
- Close
- The regulatory mechanism of phosphatidylinositol 3-kinase by insulin in 3T3 L1 fibroblasts: phosphorylation-independent activation of phosphatidylinositol 3-kinase
-
Kang IS, Choi SL, Kim SS, Kim SJ, Ha JH, Oh SM, Kim SS
- KMID: 755019
- Exp Mol Med.
- 1998 Dec;30(4):263-269.
Phosphatidylinositol (PI) 3-kinase plays an important role in transducing the signals of various growth factor receptors. However, the regulatory mechanism of PI3-kinase activity by these growth factor receptors is not... -
- CITED
-
- Close
- SHARE
-
- Close
- Apoptotic Cell Death Induced by Disruption of Epithelial Cell and Extracellular Matrix Interactions in Mouse Inner Medullary Collection Duct Cells
-
Cheon JS, Park MY, Kim YK, Lee SH, Jung JS
- KMID: 1968463
- Korean J Nephrol.
- 1999 Jan;18(1):37-45.
Cell-matrix interactions have major effects upon phenotypic features such as gene regulation, cytoskeletal structure, differentiation, and aspects of cell growth control. Upon detachment from the matrix epithelial cells enter into... -
- CITED
-
- Close
- SHARE
-
- Close
- Characterization and Differentiation of Circulating Blood Mesenchymal Stem Cells and the Role of Phosphatidylinositol 3-Kinase in Modulating the Adhesion
-
Park YK, Heo SJ, Koak JY, Park GS, Cho TJ, Kim SK, Cho J
- KMID: 2465897
- Int J Stem Cells.
- 2019 Jul;12(2):265-278.
- doi: 10.15283/ijsc18136
Bone marrow mesenchymal stem cells (BM MSCs) can differentiate into multi-lineage tissues. However, obtaining BM MSCs by aspiration is difficult and can be painful; therefore peripheral blood (PB) MSCs might... -
- CITED
-
- Close
- SHARE
-
- Close
- Insulin-Like Growth Factor 1 Actions in Developing Brain and the Interaction with Wnt Pathway
-
Lee SY
- KMID: 1434737
- Ann Pediatr Endocrinol Metab.
- 2012 Mar;17(1):10-15.
- doi: 10.6065/apem.2012.17.1.10
Insulin like growth factor (IGF)-1 signaling through type 1 IGF receptor (IGF1R) is essential to the normal growth and development of the central nervous system. IGF-1 stimulates proliferation of neural... -
- CITED
-
- Close
- SHARE
-
- Close
- The Regulation of Cyclooxygenase-2 Expressionby Interleukin-1beta in WISH cells
-
Chang YJ, Park YK, Baek SW, Lee YK, Lee DH, Lee HW
- KMID: 2262334
- Korean J Obstet Gynecol.
- 2001 Aug;44(8):1393-1400.
OBJECTIVE: To determine of the regulation of cyclooxygenase-2 (COX-2) expression by Interleukin-1beta in WISH cells. METHODS: Amnion WISH cells were incubated in media containing increasing concentrations of IL-1beta or with various... -
- CITED
-
- Close
- SHARE
-
- Close
- PIK3R3 regulates PPARα expression to stimulate fatty acid β-oxidation and decrease hepatosteatosis
-
Yang X, Fu Y, Hu F, Luo X, Hu J, Wang G
- KMID: 2438361
- Exp Mol Med.
- 2018 Jan;50(1):e431.
- doi: 10.1038/emm.2017.243
Phosphatidylinositol 3-kinase (PI3K) signaling plays an important role in the regulation of cellular lipid metabolism and non-alcoholic fatty liver disease (NAFLD). However, little is known about the role of the... -
- CITED
-
- Close
- SHARE
-
- Close
- The Role of Nuclear Factor kB and Phosphatidylinositol 3 - kinase in Trypsinogen Activation in Cerulein - Stimulated Rat Pancreatic Acini
-
Kim YJ, Kim YT, Hwang JH, Kim J, Jeong JB, Yoon YB, Kim CY
- KMID: 2085005
- Korean J Gastroenterol.
- 2001 Dec;38(6):427-432.
BACKGROUND/AIMS: Intra-acinar cell activation of trypsinogen is a critical event in cerulein-induced pancreatitis. However, little is known about the intracellular signal transduction systems involved in trypsinogen activation. This study focused... -
- CITED
-
- Close
- SHARE
-
- Close
- Angiotensin II-induced aortic ring constriction is mediated by phosphatidylinositol 3-kinase/L-type calcium channel signaling pathway
-
Do KH, Kim MS, Kim JH, Rhim BY, Lee WS, Kim CD, Bae SS
- KMID: 1119322
- Exp Mol Med.
- 2009 Aug;41(8):569-576.
- doi: 10.3858/emm.2009.41.8.062
Angiotensin II (AngII) is a crucial hormone that affects vasoconstriction and exerts hypertrophic effects on vascular smooth muscle cells. Here, we showed that phosphatidylinositol 3-kinase-dependent calcium mobilization plays pivotal roles... -
- CITED
-
- Close
- SHARE
-
- Close
- Biomarkers of Everolimus Sensitivity in Hormone Receptor-Positive Breast Cancer
-
Yi Z, Ma F
- KMID: 2398200
- J Breast Cancer.
- 2017 Dec;20(4):321-326.
- doi: 10.4048/jbc.2017.20.4.321
Activation of the mammalian target of rapamycin (mTOR) signaling pathway is an important mechanism of resistance to endocrine therapy in breast cancer. Everolimus, an mTOR inhibitor, has been shown to... -
- CITED
-
- Close
- SHARE
-
- Close
- Mechanisms of Platelet Activation and Integrin alphaIIbeta3
-
Joo SJ
- KMID: 2028756
- Korean Circ J.
- 2012 May;42(5):295-301.
- doi: 10.4070/kcj.2012.42.5.295
Platelet aggregation is not only an essential part of hemostasis, but also initiates acute coronary syndrome or ischemic stroke. The precise understanding of the activation mechanism of platelet aggregation is... -
- CITED
-
- Close
- SHARE
-
- Close
- IL-15 Induced an Increased SDF-1 Expression in the Synovial Fibroblasts of Patients with Rheumatoid Arthritis
-
Park YE, Kim SI, Park SH, Baek SH, Oh HJ, Heo YM, Cho ML
- KMID: 2334911
- J Korean Rheum Assoc.
- 2010 Sep;17(3):238-245.
OBJECTIVE: Interleukin-15 (IL-15) recruits and activates synovial T cells, and IL-15 plays an important role in amplifying and perpetuating inflammation in the pathogenesis of rheumatoid arthritis (RA). Stromal cell-derived factor-1... -
- CITED
-
- Close
- SHARE
-
- Close
- Clathrin and Lipid Raft-dependent Internalization of Porphyromonas gingivalis in Endothelial Cells
-
Kim SY, Kim SH, Choi EK, Paek YW, Kang IC
- KMID: 1727430
- Int J Oral Biol.
- 2014 Sep;39(3):131-136.
Porphyromonas gingivalis is one of the most important periodontal pathogens and has been to known to invade various types of cells, including endothelial cells. The present study investigated the mechanisms... -
- CITED
-
- Close
- SHARE
-
- Close
- Membrane Trafficking of Collecting Duct Water Channel Protein AQP2 Regulated by Akt/AS160
-
Jung HJ, Kwon TH
- KMID: 2406195
- Electrolyte Blood Press.
- 2010 Dec;8(2):59-65.
Akt (protein kinase B (PKB)) is a serine/threonine kinase that acts in the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway. The PI3K/Akt signaling pathway, triggered by growth factors and hormones including vasopressin,... -
- CITED
-
- Close
- SHARE
-
- Close
- Inhibitory effect of capsaicin on B16-F10 melanoma cell migration via the phosphatidylinositol 3-kinase/Akt/Rac1 signal pathway
-
Shin DH, Kim OH, Jun HS, Kang MK
- KMID: 1104802
- Exp Mol Med.
- 2008 Oct;40(5):486-494.
- doi: 10.3858/emm.2008.40.5.486
Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide), the major pungent ingredient of red pepper, has been reported to possess anti-carcinogenic and anti-mutagenic activities. In this study, the anti-migration activity of capsaicin on highly metastatic B16-F10... -
- CITED
-
- Close
- SHARE
-
- Close
- Molecular Mechanisms of Neutrophil Activation in Acute Lung Injury
-
Yum HK
- KMID: 1877035
- Tuberc Respir Dis.
- 2002 Dec;53(6):595-611.
- doi: 10.4046/trd.2002.53.6.595
ABBREVIATIONS: Akt/PKB protein kinase B, ALI acute lung injury, ARDS acute respiratory distress syndrome, CREB C-AMP response element binding protein, ERK extracelluar signal-related kinase, fMLP fMet-Leu-Phe, G-CSF granulocyte colony-stimulating factor,... -
- CITED
-
- Close
- SHARE
-
- Close
- The Tumor Suppressor Function of PTEN/MMAC1 through the Regulation of IGFs and IGFBPs
-
Yi HK, Hwang DJ, Kim SY, Lee DY, Hwang PH
- KMID: 1875814
- Korean J Pediatr.
- 2004 Aug;47(8):884-891.
PURPOSE: PTEN/MMAC1, a novel tumor suppressor gene, is mutated in a variety of advanced and metastatic cancers. It acts as a phosphatase, and thereby, regulates the PI-3 kinase/Akt pathway. In... -
- CITED
-
- Close
- SHARE
-
- Close
- Augmentation of Sodium Butyrate-induced Apoptosis by Phosphatidylinositol 3-kinase Inhibition in the Human Cervical Cancer Cell-line
-
Park JK, Cho CH, Ramachandran S, Shin SJ, Kwon SH, Kwon SY, Cha SD
- KMID: 2270824
- Cancer Res Treat.
- 2006 Apr;38(2):112-117.
PURPOSE: Sodium butyrate (NaBT) is principally a histone deacetylase (HDAC) inhibitor, and it has the potential to arrest HPV-positive carcinoma cells at the G1 to S phase transition of the... -
- CITED
-
- Close
- SHARE
-
- Close
