Korean J Crit Care Med.  2012 Feb;27(1):1-4. 10.4266/kjccm.2012.27.1.1.

Transfusion-related Acute Lung Injury

• Kim M

• KMID: 2301471
• DOI: http://doi.org/10.4266/kjccm.2012.27.1.1

Abstract

Transfusion-related acute lung injury (TRALI) is a significant cause of iatrogenic injuries in patients. It is also the major cause of transfusion-associated fatalities. Pathophysiologic mechanism is an implicated donor of HLA. Neutrophil antibodies and biologic response modifiers are accumulated in the stored blood products. Pulmonary endothelial activation of the host may be the response from these mediators. Treatment is supportive and will be subjected to other forms of ALL/ARDS. Diverting donors at high risk for alloimmunization may decrease the incidence of such cases.

Keyword

acute lung injury; blood transfusion

MeSH Terms

Acute Lung Injury
Antibodies
Blood Transfusion
Humans
Incidence
Neutrophils
Tissue Donors
Antibodies