Korean J Anesthesiol.  2015 Apr;68(2):101-105. 10.4097/kjae.2015.68.2.101.

Transfusion-related acute lung injury; clinical perspectives

• Kim J
• Na S

• KMID: 2236147
• DOI: http://doi.org/10.4097/kjae.2015.68.2.101

Abstract

Transfusion-related acute lung injury (TRALI) was introduced in 1983 to describe a clinical syndrome seen within 6 h of a plasma-containing blood products transfusion. TRALI is a rare transfusion complication; however, the FDA has suggested that TRALI is the leading cause of transfusion-related mortality. Understanding the pathogenesis of TRALI will facilitate adopting preventive strategies, such as deferring high plasma volume female product donors. This review outlines the clinical features, pathogenesis, treatment, and prevention of TRALI.

Keyword

Acute lung injury; Diagnosis; Etiology; Prevention and control; Prognosis; Transfusion reaction

MeSH Terms

Acute Lung Injury*
Blood Group Incompatibility
Diagnosis
Female
Humans
Mortality
Plasma Volume
Prognosis
Tissue Donors