- p21-Activated Kinases (PAKs) as a Therapeutic Target
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Koo BS
- KMID: 2277281
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2011 Dec;54(12):813-818.
- doi: 10.3342/kjorl-hns.2011.54.12.813
p21-activated kinases (PAKs) are a family of serine/threonine protein kinases comprised of six isoform (PAK1-6), all of which are direct targets of the small GTPases Rac and Cdc42. PAKs have... -
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- Molecular Mechanisms of Neutrophil Activation in Acute Lung Injury
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Yum HK
- KMID: 1877035
- Tuberc Respir Dis.
- 2002 Dec;53(6):595-611.
- doi: 10.4046/trd.2002.53.6.595
ABBREVIATIONS: Akt/PKB protein kinase B, ALI acute lung injury, ARDS acute respiratory distress syndrome, CREB C-AMP response element binding protein, ERK extracelluar signal-related kinase, fMLP fMet-Leu-Phe, G-CSF granulocyte colony-stimulating factor,... -
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- Proliferative and Synthetic Responses of Airway Smooth Muscle in Asthma
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Shim JY
- KMID: 1763535
- Korean J Pediatr.
- 2005 Jun;48(6):580-587.
New evidence is emerging that airway smooth muscle (ASM) may act as an immunomodulatory cell by providing pro-inflammatory cytokines and chemokines, polypeptide growth factors, extracellular matrix proteins, cell adhesion receptors... -
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- p21-activated kinase 1 is allostericallyInhibited by naphthoquinone (NQ) derivatives
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Oh SW, Lee KI, Choi JK, Kim KA, Kim EG, Shin EY
- KMID: 2394586
- J Biomed Transl Res.
- 2017 Jun;18(2):43-49.
- doi: 10.12729/jbtr.2017.18.2.043
The p21-activated kinases (PAKs) are a family of serine/threonine protein kinases and activated by binding with activated Rho GTPases such as Rac or Cdc42. PAKs regulate actin cytoskeletal remodeling, cell... -
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- The Role of Airway Smooth Muscle in the Pathogenesis of Asthma
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Shim JY
- KMID: 2314380
- Pediatr Allergy Respir Dis.
- 2005 Sep;15(3):227-234.
Airway smooth muscle (ASM) hypertrophy and hyperplasia, important pathological features in chronic severe asthma, contribute to irreversible airflow obstruction. ASM, which had been known to be a structural cell, may... -
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- Small molecules that allosterically inhibit p21-activated kinase activity by binding to the regulatory p21-binding domain
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Kim DJ, Choi CK, Lee CS, Park MH, Tian X, Kim ND, Lee KI, Choi JK, Ahn JH, Shin EY, Shin I, Kim EG
- KMID: 2361516
- Exp Mol Med.
- 2016 Apr;48(4):e229.
- doi: 10.1038/emm.2016.13
p21-activated kinases (PAKs) are key regulators of actin dynamics, cell proliferation and cell survival. Deregulation of PAK activity contributes to the pathogenesis of various human diseases, including cancer and neurological... -
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- p21-Activated Kinase 4 (PAK4) as a Predictive Marker of Gemcitabine Sensitivity in Pancreatic Cancer Cell Lines
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Moon SU, Kim JW, Sung JH, Kang MH, Kim SH, Chang H, Lee JO, Kim YJ, Lee KW, Kim JH, Bang SM, Lee JS
- KMID: 2148501
- Cancer Res Treat.
- 2015 Jul;47(3):501-508.
- doi: 10.4143/crt.2014.054
PURPOSE: p21-activated kinases (PAKs) are involved in cytoskeletal reorganization, gene transcription, cell proliferation and survival, and oncogenic transformation. Therefore, we hypothesized that PAK expression levels could predict the sensitivity of... -
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- Microarray Analysis of Differentially Expressed Genes in the Brains of Tubby Mice
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Lee JH, Kim CH, Kim DG, Ahn YS
- KMID: 2071657
- Korean J Physiol Pharmacol.
- 2009 Apr;13(2):91-97.
- doi: 10.4196/kjpp.2009.13.2.91
The tubby mouse is characterized by progressive retinal and cochlear degeneration and late-onset obesity. These phenotypes are caused by a loss-of-function mutation in the tub gene and are shared with... -
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- Involvement of betaPIX in angiotensin II-induced migration of vascular smooth muscle cells
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Shin EY, Lee CS, Park MH, Kim DJ, Kwak SJ, Kim EG
- KMID: 756231
- Exp Mol Med.
- 2009 Jun;41(6):387-396.
- doi: 10.3858/emm.2009.41.6.044
Angiotensin II (Ang II) stimulates migration of vascular smooth muscle cell (VSMC) in addition to its contribution to contraction and hypertrophy. It is well established that Rho GTPases regulate cellular... -
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- Identification of a Novel Deletion Region in 3q29 Microdeletion Syndrome by Oligonucleotide Array Comparative Genomic Hybridization
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Seo EJ, Jun KR, Yoo HW, Yoo HK, Lee JO
- KMID: 1096822
- Korean J Lab Med.
- 2010 Feb;30(1):70-75.
- doi: 10.3343/kjlm.2010.30.1.70
BACKGROUND: The 3q29 microdeletion syndrome is a genomic disorder characterized by mental retardation, developmental delay, microcephaly, and slight facial dysmorphism. In most cases, the microdeletion spans a 1.6-Mb region between... -
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- AKAP12 regulates vascular integrity in zebrafish
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Kwon HB, Choi YK, Lim JJ, Kwon SH, Her S, Kim HJ, Lim KJ, Ahn JC, Kim YM, Bae MK, Park JA, Jeong CH, Mochizuki , Kim KW
- KMID: 1245265
- Exp Mol Med.
- 2012 Mar;44(3):225-235.
- doi: 10.3858/emm.2012.44.3.017
The integrity of blood vessels controls vascular permeability and extravasation of blood cells, across the endothelium. Thus, the impairment of endothelial integrity leads to hemorrhage, edema, and inflammatory infiltration. However,... -
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