Clin Mol Hepatol.  2020 Oct;26(4):670-676. 10.3350/cmh.2020.0174.

Liver-lung axes in alcohol-related liver disease

Affiliations
  • 1Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, USA

Abstract

Alcohol-related liver disease (ALD) and alcohol-related susceptibility to acute lung injury are the leading causes of morbidity and mortality due to chronic alcohol abuse. Most commonly, alcohol-induced injury to both organs are evaluated independently, although they share many parallel mechanisms of injury. Moreover, recent studies indicate that there is a potential liver lung axis that may contribute to organ pathology. This mini-review explores established and potential mechanisms of organ-organ crosstalk in ALD and alcohol-related lung injury.

Keyword

Liver diseases; Alcoholic Liver disease; Acute lung injury; Respiratory distress syndrome, Adult
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