- Therapeutic Effect of a Novel Chimeric Molecule Targeting Both Somatostatin and Dopamine Receptors on Growth Hormone-Secreting Pituitary Adenomas
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Kim J, Oh JH, Harlem H, Culler MD, Ku CR, Lee EJ
- KMID: 2471734
- Endocrinol Metab.
- 2020 Mar;35(1):177-187.
- doi: 10.3803/EnM.2020.35.1.177
BACKGROUND: Acromegaly is a rare disease primarily caused by growth hormone (GH)-secreting pituitary adenomas, and its treatment is costly. Moreover, some patients are unresponsive to treatment. Hence, there are increasing... -
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- Characteristics of Renal Cell Carcinoma Harboring TPM3-ALK Fusion
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Woo CG, Yun SJ, Son SM, Lim YH, Lee OJ
- KMID: 2470924
- Yonsei Med J.
- 2020 Mar;61(3):262-266.
- doi: 10.3349/ymj.2020.61.3.262
The World Health Organization 2016 edition assigned anaplastic lymphoma kinase (ALK) rearrangement-associated renal cell carcinoma (ALK-RCC) as an emerging renal tumor entity. Identifying ALK-RCC is important because ALK inhibitors have... -
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- Epithelial PI3K-δ Promotes House Dust Mite-Induced Allergic Asthma in NLRP3 Inflammasome-Dependent and -Independent Manners
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Kim SR, Park HJ, Lee KB, Kim HJ, Jeong JS, Cho SH, Lee YC
- KMID: 2468466
- Allergy Asthma Immunol Res.
- 2020 Mar;12(2):338-358.
- doi: 10.4168/aair.2020.12.2.338
PURPOSE: Phosphoinositide 3-kinase (PI3K)-δ-dependent Akt activation is known to play critical roles in various immune responses of white blood cells in which PI3K-δ isoform is mostly expressed in contrast to... -
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- Evidence for the Presence of Long-Lived Plasma Cells in Nasal Polyps
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Zhang YN, Song J, Zhai GT, Wang H, Luo RZ, Li JX, Liao B, Ma J, Wang H, Lu X, Liu DB, Liu Z
- KMID: 2468462
- Allergy Asthma Immunol Res.
- 2020 Mar;12(2):274-291.
- doi: 10.4168/aair.2020.12.2.274
PURPOSE: Plasma cells and immunoglobulins (Igs) play a pivotal role in the induction and maintenance of chronic inflammation in nasal polyps. During secondary immune responses, plasma cell survival and Ig... -
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- Correlation of PD-L1 Expression Tested by 22C3 and SP263 in Non-Small Cell Lung Cancer and Its Prognostic Effect on EGFR Mutation–Positive Lung Adenocarcinoma
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Kim T, Cha YJ, Chang YS
- KMID: 2466620
- Tuberc Respir Dis.
- 2020 Jan;83(1):51-60.
- doi: 10.4046/trd.2019.0026
BACKGROUND: Programmed death-ligand 1 (PD-L1) expression is tested by immunohistochemistry (IHC)—22C3, SP263, and SP142. The aim of this study is to evaluate the correlation among the three methods of PD-L1... -
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- Current Status of Immunotherapy for Lung Cancer and Future Perspectives
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Kim HC, Choi CM
- KMID: 2466616
- Tuberc Respir Dis.
- 2020 Jan;83(1):14-19.
- doi: 10.4046/trd.2019.0039
Lung cancer remains the most common cause of cancer-related deaths worldwide. Although there are many possible treatments, including targeted therapies such as epidermal growth factor receptor tyrosine kinase inhibitors and... -
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- Ezrin-radixin-moesin proteins are regulated by Akt-GSK3β signaling in the rat nucleus accumbens core
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Kim WY, Cai WT, Jang JK, Kim JH
- KMID: 2466576
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):121-126.
- doi: 10.4196/kjpp.2020.24.1.121
The ezrin-radixin-moesin (ERM) proteins are a family of membrane-associated proteins known to play roles in cell-shape determination as well as in signaling pathways. We have previously shown that amphetamine decreases... -
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- Neuroprotective potential of imatinib in global ischemia-reperfusion-induced cerebral injury: possible role of Janus-activated kinase 2/signal transducer and activator of transcription 3 and connexin 43
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Wang J, Bai T, Wang N, Li H, Guo X
- KMID: 2466565
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):11-18.
- doi: 10.4196/kjpp.2020.24.1.11
The present study was aimed to explore the neuroprotective role of imatinib in global ischemia-reperfusion-induced cerebral injury along with possible mechanisms. Global ischemia was induced in mice by bilateral carotid... -
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- Ribociclib-Related Stevens–Johnson Syndrome: Oncologic Awareness, Case Report, and Literature Review
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López-Gómez V, Yarza R, Muñoz-González H, Revilla E, Enrech S, González-Valle O, Tolosa P, Ciruelos E
- KMID: 2470903
- J Breast Cancer.
- 2019 Dec;22(4):661-666.
- doi: 10.4048/jbc.2019.22.e44
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis belong to a severe dermatopathic spectrum that includes frequently fatal mucocutaneous manifestations consisting of whole epidermal necrosis and sloughing with bullous transformation, blistering,... -
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- Reviews on the Hepatotoxicity of Tyrosine Kinase Inhibitors
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Han JM, Gwak HS
- KMID: 2470459
- Korean J Clin Pharm.
- 2019 Dec;29(4):223-230.
- doi: 10.24304/kjcp.2019.29.4.223
BACKGROUND: Small-molecule tyrosine kinase inhibitors (TKIs) have had major impacts on anticancer therapy by targeting the catalytic activities of dysregulated tyrosine kinases. TKIs have not presented traditional toxicities; however, some... -
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- A PAS-Containing Histidine Kinase is Required for Conidiation, Appressorium Formation, and Disease Development in the Rice Blast Fungus, Magnaporthe oryzae
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Shin JH, Gumilang A, Kim MJ, Han JH, Kim KS
- KMID: 2470180
- Mycobiology.
- 2019 Dec;47(4):473-482.
- doi: 10.1080/12298093.2019.1689037
Rice blast disease, caused by the ascomycete fungus Magnaporthe oryzae, is one of the most important diseases in rice production. PAS (period circadian protein, aryl hydrocarbon receptor nuclear translocator protein,... -
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- Baicalein Treatment Promotes Osteoblast Proliferation and Osteogenic Differentiation through Activation of Immediate Early Response 3
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Lee SI
- KMID: 2469741
- J Dent Hyg Sci.
- 2019 Dec;19(4):254-260.
- doi: 10.17135/jdhs.2019.19.4.254
BACKGROUND: The primary aims of periodontal disease treatment is to remove dental plaque and calculus, the main causes of tooth loss, and restore periodontal tissue destroyed by inflammation. Periodontal disease... -
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- p90RSK Activation Promotes Epithelial-Mesenchymal Transition in Cisplatin-Treated Triple-Negative Breast Cancer Cells
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Jin Y, Heo KS
- KMID: 2468028
- J Bacteriol Virol.
- 2019 Dec;49(4):221-229.
- doi: 10.4167/jbv.2019.49.4.221
p90 ribosomal S6 kinase (p90RSK), one of the downstream effectors in ERK1/2 pathways, shows high expression in human breast cancer tissues. However, its role in breast cancer development and drug... -
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- Regulatory Pathway of Ion-Transporter Genes through Nrf2 Transcription Factor in Hypokalemic Condition
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Cho HJ, Ahn KY
- KMID: 2467467
- Anat Biol Anthropol.
- 2019 Dec;32(4):141-149.
- doi: 10.11637/aba.2019.32.4.141
The Nuclear factor-erythroid-2-related factor 2 (Nrf2) plays a key role in the cellular defense against oxidative stress. Low K+ increased the reactive oxygen species and it stimulate Nrf2 activation. Previous... -
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- Which Clinicopathological Factors Are Related to Tumor Size in Papillary Thyroid Cancer?
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Yoon S, Lee J, Soh E
- KMID: 2466235
- J Endocr Surg.
- 2019 Dec;19(4):95-105.
- doi: 10.16956/jes.2019.19.4.95
PURPOSE: Papillary thyroid cancer (PTC) is the most common endocrine cancer worldwide. Tumor size on observation, together with lymph node metastasis, serves as a determinant of surgery. However, not all... -
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- Inhibition of tamoxifen's therapeutic effects by emodin in estrogen receptor-positive breast cancer cell lines
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Kim YG, Park YH, Yang EY, Park WS, Park KS
- KMID: 2461898
- Ann Surg Treat Res.
- 2019 Nov;97(5):230-238.
- doi: 10.4174/astr.2019.97.5.230
PURPOSE: This study was aimed to investigate the combination effect of endoxifen and emodin on estrogen receptor (ER) positive breast cancer cell lines and to explain the mechanism of the... -
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- Parthenolide inhibits transforming growth factor β1-induced epithelial-mesenchymal transition in colorectal cancer cells
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Zhu SM, Park YR, Seo SY, Kim IH, Lee ST, Kim SW
- KMID: 2465818
- Intest Res.
- 2019 Oct;17(4):527-536.
- doi: 10.5217/ir.2019.00031
BACKGROUND/AIMS: Transforming growth factor-β1 (TGF-β1) induction of epithelial-mesenchymal transition (EMT) is one of the mechanisms by which colorectal cancer (CRC) cells acquire migratory and invasive capacities, and subsequently metastasize. Parthenolide... -
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- Spindle cell myoepithelioma of the parotid gland
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Oh SJ, Moon D
- KMID: 2462491
- Arch Craniofac Surg.
- 2019 Oct;20(5):336-340.
- doi: 10.7181/acfs.2018.02341
Myoepithelioma was recognized as a histological distinct entity by the World Health Organization (WHO) in 1991. Myoepithelial cells are believed to be of ectodermal origin. In salivary glands, the myoepithelial... -
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- Ubiquitin E3 Ligase Pellino-1 Inhibits IL-10-mediated M2c Polarization of Macrophages, Thereby Suppressing Tumor Growth
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Kim D, Koh J, Ko JS, Kim HY, Lee H, Chung DH
- KMID: 2461196
- Immune Netw.
- 2019 Oct;19(5):e32.
- doi: 10.4110/in.2019.19.e32
Pellino-1 is a ubiquitin (Ub) E3 ligase that plays a role in M1, but not M2a polarization of macrophages. However, it is unknown whether Pellino-1 regulates IL-10-mediated M2c polarization of... -
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- Serum Aminotransferase Level in Rhabdomyolysis according to Concurrent Liver Disease
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Jo KM, Heo NY, Park SH, Moon YS, Kim TO, Park J, Choi JH, Park YE, Lee J
- KMID: 2460985
- Korean J Gastroenterol.
- 2019 Oct;74(4):205-211.
- doi: 10.4166/kjg.2019.74.4.205
BACKGROUND/AIMS: The serum aminotransferase level is usually elevated in rhabdomyolysis, and these enzymes originate from the skeletal muscle. On the other hand, there is limited data showing whether the degree... -
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