- Neuroprotective effects of urolithin A on Hâ‚‚Oâ‚‚-induced oxidative stress-mediated apoptosis in SK-N-MC cells
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Kim KB, Lee S, Kim JH
- KMID: 2468507
- Nutr Res Pract.
- 2020 Feb;14(1):3-11.
- doi: 10.4162/nrp.2020.14.1.3
BACKGROUND/OBJECTIVES: Oxidative stress causes cell damage and death, which contribute to the pathogenesis of neurodegenerative diseases. Urolithin A (UA), a gut microbial-derived metabolite of ellagitannins and ellagic acid, has high... -
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- The Effect of Saccharin on the Gene Expression of NF-κB and Inflammatory Cytokines in LPS-Stimulated SW480 Colon Cancer Cells
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Choi H, Kim S, Kang H, Kim M, Kim W
- KMID: 2455070
- J Korean Diet Assoc.
- 2019 Aug;25(3):217-228.
- doi: 10.14373/JKDA.2019.25.3.217
There have been no published studies concerning the anti-inflammatory effects of corn silk on colon cancer cells. Thus, this study was conducted to investigate the effect of corn silk extract... -
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- Inhibition of MicroRNA-15a/16 Expression Alleviates Neuropathic Pain Development through Upregulation of G Protein-Coupled Receptor Kinase 2
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Li T, Wan Y, Sun L, Tao S, Chen P, Liu C, Wang K, Zhou C, Zhao G
- KMID: 2455097
- Biomol Ther.
- 2019 Jul;27(4):414-422.
- doi: 10.4062/biomolther.2018.073
There is accumulating evidence that microRNAs are emerging as pivotal regulators in the development and progression of neuropathic pain. MicroRNA-15a/16 (miR-15a/16) have been reported to play an important role in... -
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- Angiotensin II Type 1 Receptor Blocker, Fimasartan, Reduces Vascular Smooth Muscle Cell Senescence by Inhibiting the CYR61 Signaling Pathway
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Kim I, Park CS, Lee HY
- KMID: 2450393
- Korean Circ J.
- 2019 Jul;49(7):615-626.
- doi: 10.4070/kcj.2018.0379
BACKGROUND AND OBJECTIVES: Angiotensin II (Ang II) has been suggested to accelerate vascular senescence, however the molecular mechanism(s) remain unknown. METHODS: We cultured human coronary artery smooth muscle cells (hCSMCs) and... -
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- Poly-L-Lactic Acid Increases Collagen Gene Expression and Synthesis in Cultured Dermal Fibroblast (Hs68) Through the p38 MAPK Pathway
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Kim SA, Kim HS, Jung JW, Suh SI, Ryoo YW
- KMID: 2430812
- Ann Dermatol.
- 2019 Feb;31(1):97-100.
- doi: 10.5021/ad.2019.31.1.97
No abstract available. -
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- The Effects of Retinoic Acid and MAPK Inhibitors on Phosphorylation of Smad2/3 Induced by Transforming Growth Factor β1
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Lee SH, Shin JH, Shin MH, Kim YS, Chung KS, Song JH, Kim SY, Kim EY, Jung JY, Kang YA, Chang J, Park MS
- KMID: 2441729
- Tuberc Respir Dis.
- 2019 Jan;82(1):42-52.
- doi: 10.4046/trd.2017.0111
BACKGROUND: Transforming growth factor β (TGF-β), retinoic acid (RA), p38 mitogen-activated protein kinase (MAPK), and MEK signaling play critical roles in cell differentiation, proliferation, and apoptosis. We investigated the effect... -
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- Diagnostic Significance of p38 Isoforms (p38α, p38β, p38γ, p38δ) in Head and Neck Squamous Cell Carcinoma: Comparative Serum Level Evaluation and Design of Novel Peptide Inhibitor Targeting the Same
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Sahu V, Nigam L, Agnihotri , Gupta A, Shekhar S, Subbarao N, Bhaskar S, Dey S
- KMID: 2437622
- Cancer Res Treat.
- 2019 Jan;51(1):313-325.
- doi: 10.4143/crt.2018.105
PURPOSE: The p38 mitogen-activated protein kinase (MAPKs) play a crucial role in the production of pro-inflammatory cytokines and over-expression of it increase cytokines which promote cancer. Among four isoforms, p38α... -
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- Effect of Resolvin D1 and E1 on Mucin Expression in Human Airway Epithelial Cells
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Kim HG, Choi TY, Bae CH, Choi YS, Na HG, Song SY, Kim YD
- KMID: 2433171
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2019 Jan;62(1):28-35.
- doi: 10.3342/kjorl-hns.2018.00164
BACKGROUND AND OBJECTIVES: Mucin is an important component of mucus that performs the first line of defense against inhaled pathogens and particles, lubrication of organs, and protection of airway. It... -
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- Propofol promotes osteoclastic bone resorption by increasing DC-STAMP expression
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Kim EJ, Kim HJ, Baik SW, Kim KH, Ryu SJ, Kim CH, Shin SW
- KMID: 2430212
- J Dent Anesth Pain Med.
- 2018 Dec;18(6):349-359.
- doi: 10.17245/jdapm.2018.18.6.349
BACKGROUND: Propofol is an intravenous anesthetic which has antioxidant effects due to its similarity in molecular structure to α-tocopherol. It has been reported that α-tocopherol increases osteoclast fusion and bone... -
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- Recombinant Human Thioredoxin-1 Protects Macrophages from Oxidized Low-Density Lipoprotein-Induced Foam Cell Formation and Cell Apoptosis
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Zhang H, Liu Q, Lin JL, Wang Y, Zhang RX, Hou JB, Yu B
- KMID: 2429051
- Biomol Ther.
- 2018 Mar;26(2):121-129.
- doi: 10.4062/biomolther.2016.275
Oxidized low-density lipoprotein (ox-LDL)-induced macrophage foam cell formation and apoptosis play critical roles in the pathogenesis of atherosclerosis. Thioredoxin-1 (Trx) is an antioxidant that potently protects various cells from oxidative... -
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- Arginase II inhibition prevents interleukin-8 production through regulation of p38 MAPK phosphorylation activated by loss of mitochondrial membrane potential in nLDL-stimulated hAoSMCs
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Koo BH, Yi BG, Jeong MS, Kwon SH, Hoe KL, Kwon YG, Won MH, Kim YM, Ryoo S
- KMID: 2440020
- Exp Mol Med.
- 2018 Feb;50(2):e438.
- doi: 10.1038/emm.2017.254
Arginase inhibition exhibits beneficial effects in vascular endothelial and smooth muscle cells. In human aortic smooth muscle cells (hAoSMCs), native low-density lipoprotein (nLDL) induced the production of interleukin-8 (IL-8) that... -
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- IL-12 and IL-23 Production in Toxoplasma gondii- or LPS-Treated Jurkat T Cells via PI3K and MAPK Signaling Pathways
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Ismail HA, Kang BH, Kim JS, Lee JH, Choi IW, Cha GH, Yuk JM, Lee YH
- KMID: 2403712
- Korean J Parasitol.
- 2017 Dec;55(6):613-622.
- doi: 10.3347/kjp.2017.55.6.613
IL-12 and IL-23 are closely related in structure, and have been shown to play crucial roles in regulation of immune responses. However, little is known about the regulation of these... -
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- Down-Regulation of TGF-β Expression Sensitizes the Resistance of Hepatocellular Carcinoma Cells to Sorafenib
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Kang D, Han Z, Oh GH, Joo Y, Choi HJ, Song JJ
- KMID: 2418924
- Yonsei Med J.
- 2017 Sep;58(5):899-909.
- doi: 10.3349/ymj.2017.58.5.899
PURPOSE: Sorafenib, a multikinase inhibitor, is the standard therapy for patients with advanced-stage hepatocellular carcinoma (HCC). However, resistance develops to the treatment, therefore, we tried to unravel the underlying mechanism... -
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- A New Neolignan Derivative, Balanophonin Isolated from Firmiana simplex Delays the Progress of Neuronal Cell Death by Inhibiting Microglial Activation
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Lim SY, Subedi L, Shin D, Kim CS, Lee KR, Kim SY
- KMID: 2389384
- Biomol Ther.
- 2017 Sep;25(5):519-527.
- doi: 10.4062/biomolther.2016.224
Excessive activation of microglia causes the continuous production of neurotoxic mediators, which further causes neuron degeneration. Therefore, inhibition of microglial activation is a possible target for the treatment of neurodegenerative... -
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- Recombinant human bone morphogenic protein-2 Induces the Differentiation and Mineralization of Osteoblastic Cells Under Hypoxic Conditions via Activation of Protein Kinase D and p38 Mitogen-Activated Protein Kinase Signaling Pathways
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Ha WH, Seong HS, Choi NR, Park BS, Kim YD
- KMID: 2394977
- Tissue Eng Regen Med.
- 2017 Aug;14(4):433-441.
- doi: 10.1007/s13770-017-0046-1
Hypoxia suppresses osteoblastic differentiation and the bone-forming capacity. As the leading osteoinductive growth factor used clinically in bone-related regenerative medicine, recombinant human bone morphogenic protein-2 (rhBMP- 2) has yielded promising... -
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- Neuroprotective effects of erythropoietin against hypoxic injury via modulation of the mitogen-activated protein kinase pathway and apoptosis
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Jeong JE, Park JH, Kim CS, Lee SL, Chung HL, Kim WT, Lee EJ
- KMID: 2383997
- Korean J Pediatr.
- 2017 Jun;60(6):181-188.
- doi: 10.3345/kjp.2017.60.6.181
PURPOSE: Hypoxic-ischemic encephalopathy is a significant cause of neonatal morbidity and mortality. Erythropoietin (EPO) is emerging as a therapeutic candidate for neuroprotection. Therefore, this study was designed to determine the... -
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- Asian Sand Dust Up-Regulates MUC4 Expression in Human Upper Airway Epithelial Cells
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Park CH, Song YS, Bae CH, Choi YS, Song SY, Shin KC, Jin HJ, Kim YD
- KMID: 2379917
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2017 May;60(5):222-231.
- doi: 10.3342/kjorl-hns.2016.17594
BACKGROUND AND OBJECTIVES: Asian sand dust (ASD) is a meteorological phenomenon that occurs in spring time in Korea. ASD is composed of various organic and inorganic materials, which induce airway... -
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- Mitogen-activated Protein Kinases in the Development of Normal and Diseased Kidneys
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Awazu M
- KMID: 2377561
- Child Kidney Dis.
- 2017 Apr;21(1):1-7.
- doi: 10.3339/jkspn.2017.21.1.1
Mitogen-activated protein kinases (MAPKs) play important roles in various cellular functions including proliferation, differentiation, and apoptosis. We showed that MAPKs are developmentally regulated in the rat kidney. p38 MAPK (p38)... -
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- Effect of High Glucose on MUC5B Expression in Human Airway Epithelial Cells
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Ye SB, Choi YS, Choi YH, Bae CH, Kim YW, Park SY, Song SY, Kim YD
- KMID: 2376412
- Clin Exp Otorhinolaryngol.
- 2017 Mar;10(1):77-84.
- doi: https://doi.org/10.21053/ceo.2016.00045
OBJECTIVES: Excessive production of mucus results in plugging of the airway tract, which can increase morbidity and mortality in affected patients. In patients with diabetes, inflammatory airway disease appears with... -
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- Hyperbaric Oxygen Pretreatment Improves Cognition and Reduces Hippocampal Damage Via p38 Mitogen-Activated Protein Kinase in a Rat Model
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Zhao B, Pan Y, Wang Z, Xu H, Song X
- KMID: 2374198
- Yonsei Med J.
- 2017 Jan;58(1):131-138.
- doi: 10.3349/ymj.2017.58.1.131
PURPOSE: To investigate the effects of hyperbaric oxygen (HBO) pretreatment on cognitive decline and neuronal damage in an Alzheimer’s disease (AD) rat model. MATERIALS AND METHODS: Rats were divided into three... -
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