- Mitogen-activated Protein Kinases in Inflammation
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Manzoor Z, Koh YS
- KMID: 1434747
- J Bacteriol Virol.
- 2012 Sep;42(3):189-195.
- doi: 10.4167/jbv.2012.42.3.189
Mitogen-activated protein kinases (MAPKs) play critical regulatory roles in the production of the pro-inflammatory cytokines and downstream signaling events which lead to inflammation. Inflammation is a primarily localized and protective... -
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- Mitogen-activated Protein Kinases in the Development of Normal and Diseased Kidneys
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Awazu M
- KMID: 2377561
- Child Kidney Dis.
- 2017 Apr;21(1):1-7.
- doi: 10.3339/jkspn.2017.21.1.1
Mitogen-activated protein kinases (MAPKs) play important roles in various cellular functions including proliferation, differentiation, and apoptosis. We showed that MAPKs are developmentally regulated in the rat kidney. p38 MAPK (p38)... -
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- The role of p38 MAP kinase on RANKL regulation in mouse periodontal ligament fibroblasts
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Kim JC, Cui DZ, Kim YJ
- KMID: 1511576
- J Korean Acad Periodontol.
- 2007 Aug;37(Suppl):311-323.
- doi: 10.5051/jkape.2007.37.Suppl.311
No abstract available. -
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- Blockade of p38 Mitogen-activated Protein Kinase Pathway Inhibits Interleukin-6 Release and Expression in Primary Neonatal Cardiomyocytes
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Chae HJ, Kim HK, Lee WK, Chae SW
- KMID: 1615199
- Korean J Physiol Pharmacol.
- 2002 Dec;6(6):319-325.
The induction of interleukin-6 (IL-6) using combined proinflammatory agents (LPS/IFN-gamma or TNF-alpha/IFN-gamma) was studied in relation to p38 mitogen-activated protein kinase (MAPK) and NF-kappaB transcriptional factor in primary neonatal cardiomyocytes.... -
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- Poly-L-Lactic Acid Increases Collagen Gene Expression and Synthesis in Cultured Dermal Fibroblast (Hs68) Through the p38 MAPK Pathway
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Kim SA, Kim HS, Jung JW, Suh SI, Ryoo YW
- KMID: 2430812
- Ann Dermatol.
- 2019 Feb;31(1):97-100.
- doi: 10.5021/ad.2019.31.1.97
No abstract available. -
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- Angiotensin Converting Enzyme Inhibition Modulates Mitogen Activated Protein Kinase Family Expressions in the Neonatal Rat Kidney
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Choi BM, Oh MH, Yoo KH
- KMID: 2278709
- Korean J Pediatr.
- 2004 Mar;47(3):325-331.
PURPOSE: In a developing kidney, the renin-angiotensin system(RAS) is markedly activated and is thought to play an important role in postnatal renal growth and maturation. We previously demonstrated that angiotensin... -
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- IL-1beta Induces Lysozyme Overexpression through a Mechanism Involving ERK/p38 Mitogen Activated Protein Kinase Activation in Human Airway Epithelial Cells
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Kim YS, Yang WS, Moon UY, Lee JG, Yoon JH
- KMID: 2297667
- J Rhinol.
- 2007 Nov;14(2):100-105.
BACKGROUND AND OBJECTIVES: Lysozyme, a major serous component of airway epithelial secretions, plays an important role in airway defense. However, little is understood about the regulation of its expression and... -
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- Nectandrin A Enhances the BMP-Induced Osteoblastic Differentiation and Mineralization by Activation of p38 MAPK-Smad Signaling Pathway
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Kim DY, Kim GW, Chung SH
- KMID: 1500241
- Korean J Physiol Pharmacol.
- 2013 Oct;17(5):447-453.
- doi: 10.4196/kjpp.2013.17.5.447
Osteoblastic activity of nectandrin A was examined in C2C12 cells. Nectandrin A enhances the BMP-induced osteoblastic differentiation and mineralization, manifested by the up-regulation of differentiation markers (alkaline phosphatase and osteogenic... -
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- Dexamethasone Inhibits Interleukin-1beta-Induced Matrix Metalloproteinase-9 Expression in Cochlear Cells
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Nam SI, Kwon TK
- KMID: 1973466
- Clin Exp Otorhinolaryngol.
- 2014 Sep;7(3):175-180.
- doi: 10.3342/ceo.2014.7.3.175
OBJECTIVES: To investigate the effect of interleukin (IL)-1beta on matrix metalloproteinase (MMP)-9 expression in cochlea and regulation of IL-1beta-mediated MMP-9 expression by dexamethasone and the molecular and signaling mechanisms involved. METHODS:... -
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- Role of Reactive Oxygen Species and Mitogen-activated Protein Kinases in 2, 3, 7, 8-tetrachlorodibinzo-p-dioxin-induced Fibronectin Secretion by MDCK Cells
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Yu MR, Ha H
- KMID: 2254244
- Korean J Nephrol.
- 2005 May;24(3):350-357.
BACKGROUND: 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD: dioxin) is a potent environmental toxicant that alters various cell function. Both reactive oxygen species (ROS) and mitogen-activated protein kinases (MAPK) mediate dioxin-induced cytotoxicity.... -
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- Ketamine reduces the induced spinal p38 MAPK and pro-inflammatory cytokines in a neuropathic rats
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Kwon SY, Yeom JH, Joo JD
- KMID: 2237244
- Korean J Anesthesiol.
- 2014 Jan;66(1):52-58.
- doi: 10.4097/kjae.2014.66.1.52
BACKGROUND: Neuropathic rats created by spinal nerve ligation are known to show higher levels of p38, c-Jun NH2-terminal kinase, and extracellular signal-regulated kinase p44/42 (ERK 1/2) of the mitogen-activated protein... -
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- p38 MAPK and NF-kappaB are required for LPS-induced RANTES production in immortalized murine microglia (BV-2)
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Jang SB, Lee KH
- KMID: 1580930
- Korean J Physiol Pharmacol.
- 2000 Oct;4(5):339-346.
Using murine immortalized microglial cells (BV-2), we examined the regulation of RANTES production stimulated by lipopolysaccharide (LPS), focusing on the role of mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-kappaB. The result showed... -
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- Impaired Expression of MAPK Is Associated with the Downregulation of TNF-alpha, IL-6, and IL-10 in Mycobacterium abscessus Lung Disease
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Sim YS, Kim SY, Kim EJ, Shin SJ, Koh WJ
- KMID: 2319798
- Tuberc Respir Dis.
- 2012 Mar;72(3):275-283.
BACKGROUND: Healthy individuals who develop nontuberculous mycobacteria (NTM) lung disease are likely to have specific susceptibility factors which can lead to a NTM infection. The aim of the present study... -
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- Berberine Suppresses Interleukin-1beta-Induced MUC5AC Gene Expression in Human Airway Epithelial Cells
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Kim KR, Kim NH, Park Y, Kim JH, Lee EJ, Kim KS
- KMID: 2297593
- J Rhinol.
- 2011 Nov;18(2):116-121.
OBJECTIVES: The aim of this study was to investigate whether berberine suppresses interleukin (IL)-1beta-induced MUC5AC gene expression in human airway epithelial cells and, if so, to determine which mitogen-activated protein... -
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- Effects of Mycoplasma Pneumoniae on Activation of Human Eosinophilic Leukaemia EoL-1 Cells
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Kim ES, Lee KE, Yang HS, Kim KW, Park JY, Sohn MH, Kim KE
- KMID: 2314450
- Pediatr Allergy Respir Dis.
- 2007 Mar;17(1):8-16.
PURPOSE: Mycoplasma pneumoniae is a common cause of lower respiratory disease, especially in children and young adults. Several studies have suggested that respiratory infection by M. pneumoniae is associated with... -
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- Regulation of homotypic aggregation of myeloma-derived cell line IM-9 by CD82
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Hahn JH, Kim DJ
- KMID: 2030736
- Korean J Anat.
- 2001 Feb;34(1):23-32.
Although reduced expression of CD82 transmembrane protein facilitates metastasis of cancer cells, little is known about its biological function. Here we have investigated the role of CD82 in B cell... -
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- Activation of Mitogen-Activated Protein Kinases in the Rat Dorsal Root Ganglia Following Peripheral Tissue Inflammation or Nerve Injuries
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Bae JC, Lee HL, Lee KM, Hwang SH, Sohn SJ, Kim DS, Cho HJ
- KMID: 1514946
- Korean J Anat.
- 2003 Jun;36(3):237-246.
The mitogen-activated protein kinase (MAPK) family has three members: the extracellular signal-regulated kinase (ERK), p38 MAPK and c-Jun N-terminal kinase (JNK). There is substantial evidence indicating that the MAPK cascade... -
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- Lonchocarpine Increases Nrf2/ARE-Mediated Antioxidant Enzyme Expression by Modulating AMPK and MAPK Signaling in Brain Astrocytes
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Jeong YH, Park JS, Kim DH, Kim HS
- KMID: 2374611
- Biomol Ther.
- 2016 Nov;24(6):581-588.
- doi: 10.4062/biomolther.2016.141
Lonchocarpine is a phenylpropanoid compound isolated from Abrus precatorius that has anti-bacterial, anti-inflammatory, antiproliferative, and antiepileptic activities. In the present study, we investigated the antioxidant effects of lonchocarpine in brain... -
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- Involvement of Caenohabditis elegans MAPK Signaling Pathways in Oxidative Stress Response Induced by Silver Nanoparticles Exposure
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Roh JY, Eom HJ, Choi J
- KMID: 2052547
- Toxicol Res.
- 2012 Mar;28(1):19-24.
In the present study, toxicity of silver nanoparticles (AgNPs) was investigated in the nematode, Caenohabditis elegans focusing on the upstream signaling pathway responsible for regulating oxidative stress, such as mitogen-activated... -
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- Quinpirole Increases Melatonin-Augmented Pentobarbital Sleep via Cortical ERK, p38 MAPK, and PKC in Mice
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Hong SI, Kwon SH, Hwang JY, Ma SX, Seo JY, Ko YH, Kim HC, Lee SY, Jang CG
- KMID: 2170522
- Biomol Ther.
- 2016 Mar;24(2):115-122.
- doi: 10.4062/biomolther.2015.097
Sleep, which is an essential part of human life, is modulated by neurotransmitter systems, including gamma-aminobutyric acid (GABA) and dopamine signaling. However, the mechanisms that initiate and maintain sleep remain... -
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