- Inhibitory Effect of Rosae Multiflorae Fructus Extracts on the Receptor Activator of NF-κB Ligand-Induced Osteoclastogenesis through Modulation of P38- and Ca2âº-Mediated Nuclear Factor of Activated T-Cells Cytoplasmic 1 Expression
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Park KH, Gu DR, Kim MS, Lee SH
- KMID: 2471314
- J Bone Metab.
- 2020 Feb;27(1):53-63.
- doi: 10.11005/jbm.2020.27.1.53
BACKGROUND: Rosae Multiflorae fructus (RMF), known to have anti-inflammatory and antioxidant properties, has been used as a traditional remedy for inflammatory diseases such as arthritis in Eastern Asia. However, its... -
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- Neuroprotective effects of urolithin A on Hâ‚‚Oâ‚‚-induced oxidative stress-mediated apoptosis in SK-N-MC cells
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Kim KB, Lee S, Kim JH
- KMID: 2468507
- Nutr Res Pract.
- 2020 Feb;14(1):3-11.
- doi: 10.4162/nrp.2020.14.1.3
BACKGROUND/OBJECTIVES: Oxidative stress causes cell damage and death, which contribute to the pathogenesis of neurodegenerative diseases. Urolithin A (UA), a gut microbial-derived metabolite of ellagitannins and ellagic acid, has high... -
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- Curcumin Attenuates Acrolein-induced COX-2 Expression and Prostaglandin Production in Human Umbilical Vein Endothelial Cells
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Lee SE, Park HR, Jeon S, Han D, Park YS
- KMID: 2470810
- J Lipid Atheroscler.
- 2020 Jan;9(1):184-194.
- doi: 10.12997/jla.2020.9.1.184
OBJECTIVE: Inflammation is crucial to limiting vascular disease. Previously we reported that acrolein, a known toxin in tobacco smoke, might play an important role in the progression of atherosclerosis via... -
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- Quercetin-induced apoptosis ameliorates vascular smooth muscle cell senescence through AMP-activated protein kinase signaling pathway
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Kim SG, Sung JY, Kim JR, Choi HC
- KMID: 2466571
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):69-79.
- doi: 10.4196/kjpp.2020.24.1.69
Aging is one of the risk factors for the development of cardiovascular diseases. During the progression of cellular senescence, cells enter a state of irreversible growth arrest and display resistance... -
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- Medium- and long-chain triglyceride propofol reduces the activity of acetyl-coenzyme A carboxylase in hepatic lipid metabolism in HepG2 and Huh7 cells
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Wang LY, Wu J, Gao YF, Lin DM, Ma J
- KMID: 2466566
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):19-26.
- doi: 10.4196/kjpp.2020.24.1.19
Medium- and long-chain triglyceride (MCT/LCT) propofol is widely used as an intravenous anesthetic, especially in the intensive care unit. The present study aimed to assess whether MCT/LCT propofol is safe... -
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- Baicalein Treatment Promotes Osteoblast Proliferation and Osteogenic Differentiation through Activation of Immediate Early Response 3
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Lee SI
- KMID: 2469741
- J Dent Hyg Sci.
- 2019 Dec;19(4):254-260.
- doi: 10.17135/jdhs.2019.19.4.254
BACKGROUND: The primary aims of periodontal disease treatment is to remove dental plaque and calculus, the main causes of tooth loss, and restore periodontal tissue destroyed by inflammation. Periodontal disease... -
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- Docosahexaenoic Acid Inhibits Expression of Fibrotic Mediators in Mice With Chronic Pancreatitis
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Lee S, Jeong YK, Lim JW, Kim H
- KMID: 2468813
- J Cancer Prev.
- 2019 Dec;24(4):233-239.
- doi: 10.15430/JCP.2019.24.4.233
BACKGROUND: Chronic pancreatitis (CP) is an irreversible progressive disease that destroys exocrine parenchyma, which are replaced by fibrous tissue. As pancreatic fibrosis is a key feature of CP, reducing fibrotic... -
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- Anti-arthritic Effects of Oplopanax elatus in a Rat Model of Rheumatoid Arthritis (Adjuvant-induced Arthritis)
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Kwon KS, Lim H, Kwon YS, Choi HR, Kim MJ, Yoo JH, Yoo NH, Kim HP
- KMID: 2468063
- Nat Prod Sci.
- 2019 Dec;25(4):304-310.
- doi: 10.20307/nps.2019.25.4.304
The stems of Oplopanax elatus (OE) have long been used to treat inflammatory disorders in herbal medicine, and in the previous investigation, OE was found to possess anti-inflammatory activity in... -
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- Asiatic Acid Induces Apoptosis and Autophagy and Reduces MiR-17 and MiR-21 Expression in Pancreatic Cancer Cell Lines
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Jo YG, Kim M, Shin H, Lee KY, Lee EJ
- KMID: 2468062
- Nat Prod Sci.
- 2019 Dec;25(4):298-303.
- doi: 10.20307/nps.2019.25.4.298
This study investigated the cytotoxic effects and mechanism of action of asiatic acid in pancreatic cancer cell lines. First, we confirmed the cell viability of MIA PaCa-2 and PANC-1 cells... -
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- Metformin Ameliorates Lipotoxic β-Cell Dysfunction through a Concentration-Dependent Dual Mechanism of Action
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Kim HI, Lee JS, Kwak BK, Hwang WM, Kim MJ, Kim YB, Chung SS, Park KS
- KMID: 2466506
- Diabetes Metab J.
- 2019 Dec;43(6):854-866.
- doi: 10.4093/dmj.2018.0179
BACKGROUND: Chronic exposure to elevated levels of free fatty acids contributes to pancreatic β-cell dysfunction. Although it is well known that metformin induces cellular energy depletion and a concomitant activation... -
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- Rhodanthpyrone A and B play an anti-inflammatory role by suppressing the nuclear factor-κB pathway in macrophages
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Kim KS, Han CY, Han YT, Bae EJ
- KMID: 2461042
- Korean J Physiol Pharmacol.
- 2019 Nov;23(6):493-499.
- doi: 10.4196/kjpp.2019.23.6.493
Macrophage-associated inflammation is crucial for the pathogenesis of diverse diseases including metabolic disorders. Rhodanthpyrone (Rho) is an active component of Gentiana rhodantha, which has been used in traditional Chinese medicine... -
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- Transduced Tat-aldose Reductase Protects Hippocampal Neuronal Cells against Oxidative Stress-induced Damage
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Cho SB, Eum WS, Shin MJ, Kwon HJ, Park JH, Choi YJ, Park J, Han KH, Kang JH, Kim DS, Cho SW, Kim DW, Choi SY
- KMID: 2463716
- Exp Neurobiol.
- 2019 Oct;28(5):612-627.
- doi: 10.5607/en.2019.28.5.612
Aldose reductase (AR) protein, a member of the NADPH-dependent aldo-keto reductase family, reduces a wide range of aldehydes and enhances cell survival by inhibition of oxidative stress. Oxidative stress is... -
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- ¹H-NMR Analysis of Metabolic Changes Induced by Snf1/AMP-Activated Protein Kinase During Environmental Stress Responses
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Kim J, Oh J, Yoon DH, Sung GH
- KMID: 2470147
- Mycobiology.
- 2019 Sep;47(3):346-349.
- doi: 10.1080/12298093.2019.1625854
AMP-activated protein kinase sucrose non-fermenting 1 (Snf1) is a representative regulator of energy status that maintains cellular energy homeostasis. In addition, Snf1 is involved in the mediation of environmental stress... -
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- Recent Advances in Anti-Aging Medicine
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Son DH, Park WJ, Lee YJ
- KMID: 2459566
- Korean J Fam Med.
- 2019 Sep;40(5):289-296.
- doi: 10.4082/kjfm.19.0087
A rapidly aging population in Korea has led to increased attention in the field of anti-aging medicine. The purpose of anti-aging medicine is to slow, stop, or reverse the aging... -
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- Cyclosporin A aggravates hydrogen peroxide-induced cell death in kidney proximal tubule epithelial cells
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Moon D, Kim J
- KMID: 2459547
- Anat Cell Biol.
- 2019 Sep;52(3):312-323.
- doi: 10.5115/acb.18.192
Cyclosporin A (CsA) does not only exert a toxic effect on kidney parenchymal cells, but also protects them against necrotic cell death by inhibiting opening of mitochondrial permeability transition pore.... -
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- Transcriptome Analysis Identifies an Attenuated Local Immune Response in Invasive Nonfunctioning Pituitary Adenomas
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Kim YH, Kim JH
- KMID: 2458634
- Endocrinol Metab.
- 2019 Sep;34(3):314-322.
- doi: 10.3803/EnM.2019.34.3.314
BACKGROUND: Invasive nonfunctioning pituitary adenomas (NFPAs) remain challenging due to their high complication rate and poor prognosis. We aimed to identify the distinctive molecular signatures of invasive NFPAs, compared with... -
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- Effects of Oxytocin on Cell Proliferation in a Corticotroph Adenoma Cell Line
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Lim JS, Eom YW, Lee ES, Kwon HJ, Kwon JY, Choi J, Chung CH, Jo YS, Lee EJ
- KMID: 2458633
- Endocrinol Metab.
- 2019 Sep;34(3):302-313.
- doi: 10.3803/EnM.2019.34.3.302
BACKGROUND: Oxytocin (OXT) has been reported to act as a growth regulator in various tumor cells. However, there is a paucity of data on the influence of OXT on cell... -
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- Radioactive Iodine-Refractory Differentiated Thyroid Cancer and Redifferentiation Therapy
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Liu J, Liu Y, Lin Y, Liang J
- KMID: 2458623
- Endocrinol Metab.
- 2019 Sep;34(3):215-225.
- doi: 10.3803/EnM.2019.34.3.215
The retained functionality of the sodium iodide symporter (NIS) expressed in differentiated thyroid cancer (DTC) cells allows the further utilization of post-surgical radioactive iodine (RAI) therapy, which is an effective... -
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- Anti-malarial Drugs Reduce Vascular Smooth Muscle Cell Proliferation via Activation of AMPK and Inhibition of Smad3 Signaling
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Lee H, Han JH, Kim S, Kim S, Cho DH, Woo CH
- KMID: 2458392
- J Lipid Atheroscler.
- 2019 Sep;8(2):267-276.
- doi: 10.12997/jla.2019.8.2.267
OBJECTIVE: The aim of this study was to investigate the effects of 2 anti-malarial drugs, chloroquine (CQ) and hydroxychloroquine (HCQ), on inhibition of vascular smooth muscle cell (VSMC) proliferation both... -
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- Novel Isoquinolinamine and Isoindoloquinazolinone Compounds Exhibit Antiproliferative Activity in Acute Lymphoblastic Leukemia Cells
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Roolf C, Saleweski , Stein A, Richter A, Maletzki C, Sekora A, Escobar HM, Wu XF, Beller M, Junghanss
- KMID: 2456224
- Biomol Ther.
- 2019 Sep;27(5):492-501.
- doi: 10.4062/biomolther.2018.199
Nitrogen-containing heterocycles such as quinoline, quinazolinones and indole are scaffolds of natural products and have broad biological effects. During the last years those structures have been intensively synthesized and modified... -
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