- Inhibitory Effect of Rosae Multiflorae Fructus Extracts on the Receptor Activator of NF-κB Ligand-Induced Osteoclastogenesis through Modulation of P38- and Ca2âº-Mediated Nuclear Factor of Activated T-Cells Cytoplasmic 1 Expression
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Park KH, Gu DR, Kim MS, Lee SH
- KMID: 2471314
- J Bone Metab.
- 2020 Feb;27(1):53-63.
- doi: 10.11005/jbm.2020.27.1.53
BACKGROUND: Rosae Multiflorae fructus (RMF), known to have anti-inflammatory and antioxidant properties, has been used as a traditional remedy for inflammatory diseases such as arthritis in Eastern Asia. However, its... -
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- Neuroprotective effects of urolithin A on Hâ‚‚Oâ‚‚-induced oxidative stress-mediated apoptosis in SK-N-MC cells
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Kim KB, Lee S, Kim JH
- KMID: 2468507
- Nutr Res Pract.
- 2020 Feb;14(1):3-11.
- doi: 10.4162/nrp.2020.14.1.3
BACKGROUND/OBJECTIVES: Oxidative stress causes cell damage and death, which contribute to the pathogenesis of neurodegenerative diseases. Urolithin A (UA), a gut microbial-derived metabolite of ellagitannins and ellagic acid, has high... -
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- Curcumin Attenuates Acrolein-induced COX-2 Expression and Prostaglandin Production in Human Umbilical Vein Endothelial Cells
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Lee SE, Park HR, Jeon S, Han D, Park YS
- KMID: 2470810
- J Lipid Atheroscler.
- 2020 Jan;9(1):184-194.
- doi: 10.12997/jla.2020.9.1.184
OBJECTIVE: Inflammation is crucial to limiting vascular disease. Previously we reported that acrolein, a known toxin in tobacco smoke, might play an important role in the progression of atherosclerosis via... -
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- Quercetin-induced apoptosis ameliorates vascular smooth muscle cell senescence through AMP-activated protein kinase signaling pathway
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Kim SG, Sung JY, Kim JR, Choi HC
- KMID: 2466571
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):69-79.
- doi: 10.4196/kjpp.2020.24.1.69
Aging is one of the risk factors for the development of cardiovascular diseases. During the progression of cellular senescence, cells enter a state of irreversible growth arrest and display resistance... -
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- Medium- and long-chain triglyceride propofol reduces the activity of acetyl-coenzyme A carboxylase in hepatic lipid metabolism in HepG2 and Huh7 cells
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Wang LY, Wu J, Gao YF, Lin DM, Ma J
- KMID: 2466566
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):19-26.
- doi: 10.4196/kjpp.2020.24.1.19
Medium- and long-chain triglyceride (MCT/LCT) propofol is widely used as an intravenous anesthetic, especially in the intensive care unit. The present study aimed to assess whether MCT/LCT propofol is safe... -
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- ¹H-NMR Analysis of Metabolic Changes Induced by Snf1/AMP-Activated Protein Kinase During Environmental Stress Responses
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Kim J, Oh J, Yoon DH, Sung GH
- KMID: 2470147
- Mycobiology.
- 2019 Sep;47(3):346-349.
- doi: 10.1080/12298093.2019.1625854
AMP-activated protein kinase sucrose non-fermenting 1 (Snf1) is a representative regulator of energy status that maintains cellular energy homeostasis. In addition, Snf1 is involved in the mediation of environmental stress... -
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- Recent Advances in Anti-Aging Medicine
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Son DH, Park WJ, Lee YJ
- KMID: 2459566
- Korean J Fam Med.
- 2019 Sep;40(5):289-296.
- doi: 10.4082/kjfm.19.0087
A rapidly aging population in Korea has led to increased attention in the field of anti-aging medicine. The purpose of anti-aging medicine is to slow, stop, or reverse the aging... -
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- Cyclosporin A aggravates hydrogen peroxide-induced cell death in kidney proximal tubule epithelial cells
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Moon D, Kim J
- KMID: 2459547
- Anat Cell Biol.
- 2019 Sep;52(3):312-323.
- doi: 10.5115/acb.18.192
Cyclosporin A (CsA) does not only exert a toxic effect on kidney parenchymal cells, but also protects them against necrotic cell death by inhibiting opening of mitochondrial permeability transition pore.... -
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- Transcriptome Analysis Identifies an Attenuated Local Immune Response in Invasive Nonfunctioning Pituitary Adenomas
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Kim YH, Kim JH
- KMID: 2458634
- Endocrinol Metab.
- 2019 Sep;34(3):314-322.
- doi: 10.3803/EnM.2019.34.3.314
BACKGROUND: Invasive nonfunctioning pituitary adenomas (NFPAs) remain challenging due to their high complication rate and poor prognosis. We aimed to identify the distinctive molecular signatures of invasive NFPAs, compared with... -
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- Effects of Oxytocin on Cell Proliferation in a Corticotroph Adenoma Cell Line
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Lim JS, Eom YW, Lee ES, Kwon HJ, Kwon JY, Choi J, Chung CH, Jo YS, Lee EJ
- KMID: 2458633
- Endocrinol Metab.
- 2019 Sep;34(3):302-313.
- doi: 10.3803/EnM.2019.34.3.302
BACKGROUND: Oxytocin (OXT) has been reported to act as a growth regulator in various tumor cells. However, there is a paucity of data on the influence of OXT on cell... -
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- Radioactive Iodine-Refractory Differentiated Thyroid Cancer and Redifferentiation Therapy
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Liu J, Liu Y, Lin Y, Liang J
- KMID: 2458623
- Endocrinol Metab.
- 2019 Sep;34(3):215-225.
- doi: 10.3803/EnM.2019.34.3.215
The retained functionality of the sodium iodide symporter (NIS) expressed in differentiated thyroid cancer (DTC) cells allows the further utilization of post-surgical radioactive iodine (RAI) therapy, which is an effective... -
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- Anti-malarial Drugs Reduce Vascular Smooth Muscle Cell Proliferation via Activation of AMPK and Inhibition of Smad3 Signaling
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Lee H, Han JH, Kim S, Kim S, Cho DH, Woo CH
- KMID: 2458392
- J Lipid Atheroscler.
- 2019 Sep;8(2):267-276.
- doi: 10.12997/jla.2019.8.2.267
OBJECTIVE: The aim of this study was to investigate the effects of 2 anti-malarial drugs, chloroquine (CQ) and hydroxychloroquine (HCQ), on inhibition of vascular smooth muscle cell (VSMC) proliferation both... -
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- Novel Isoquinolinamine and Isoindoloquinazolinone Compounds Exhibit Antiproliferative Activity in Acute Lymphoblastic Leukemia Cells
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Roolf C, Saleweski , Stein A, Richter A, Maletzki C, Sekora A, Escobar HM, Wu XF, Beller M, Junghanss
- KMID: 2456224
- Biomol Ther.
- 2019 Sep;27(5):492-501.
- doi: 10.4062/biomolther.2018.199
Nitrogen-containing heterocycles such as quinoline, quinazolinones and indole are scaffolds of natural products and have broad biological effects. During the last years those structures have been intensively synthesized and modified... -
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- Humanin suppresses receptor activator of nuclear factor-κB ligand-induced osteoclast differentiation via AMP-activated protein kinase activation
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Kang N, Kim KW, Shin DM
- KMID: 2455817
- Korean J Physiol Pharmacol.
- 2019 Sep;23(5):411-417.
- doi: 10.4196/kjpp.2019.23.5.411
Humanin (HN) is a mitochondrial peptide that exhibits cytoprotective actions against various stresses and diseases. HN has been shown to induce the phosphorylation of AMP-activated protein kinase (AMPK), which is... -
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- The Effect of Saccharin on the Gene Expression of NF-κB and Inflammatory Cytokines in LPS-Stimulated SW480 Colon Cancer Cells
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Choi H, Kim S, Kang H, Kim M, Kim W
- KMID: 2455070
- J Korean Diet Assoc.
- 2019 Aug;25(3):217-228.
- doi: 10.14373/JKDA.2019.25.3.217
There have been no published studies concerning the anti-inflammatory effects of corn silk on colon cancer cells. Thus, this study was conducted to investigate the effect of corn silk extract... -
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- Protective effect of Cordyceps militaris against hydrogen peroxide-induced oxidative stress in vitro
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He MT, Lee AY, Park CH, Cho EJ
- KMID: 2453105
- Nutr Res Pract.
- 2019 Aug;13(4):279-285.
- doi: 10.4162/nrp.2019.13.4.279
BACKGROUND/OBJECTIVES: Excessive production of reactive oxygen species (ROS) such as hydroxyl (·OH), nitric oxide (NO), and hydrogen peroxide (H2O2) is reported to induce oxidative stress. ROS generated by oxidative stress... -
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- Inhibition of MicroRNA-15a/16 Expression Alleviates Neuropathic Pain Development through Upregulation of G Protein-Coupled Receptor Kinase 2
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Li T, Wan Y, Sun L, Tao S, Chen P, Liu C, Wang K, Zhou C, Zhao G
- KMID: 2455097
- Biomol Ther.
- 2019 Jul;27(4):414-422.
- doi: 10.4062/biomolther.2018.073
There is accumulating evidence that microRNAs are emerging as pivotal regulators in the development and progression of neuropathic pain. MicroRNA-15a/16 (miR-15a/16) have been reported to play an important role in... -
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- 7,8,4′-Trihydroxyisoflavone, a Metabolized Product of Daidzein, Attenuates 6-Hydroxydopamine-Induced Neurotoxicity in SH-SY5Y Cells
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Ko YH, Kim SK, Kwon SH, Seo JY, Lee BR, Kim YJ, Hur KH, Kim SY, Lee SY, Jang CG
- KMID: 2455091
- Biomol Ther.
- 2019 Jul;27(4):363-372.
- doi: 10.4062/biomolther.2018.211
Daidzein isolated from soybean (Glycine max) has been widely studied for its antioxidant and anti-inflammatory activities. However, the protective effects of 7,8,4′-trihydroxyisoflavone (THIF), a major metabolite of daidzein, on 6-hydroxydopamine... -
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- Vagal Transient Receptor Potential Ankyrin 1 Mediates Stress-exacerbated Visceral Mechanonociception After Antral Cold Exposure
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Chen X, Luo Q, Yan X, Li W, Chen S
- KMID: 2454643
- J Neurogastroenterol Motil.
- 2019 Jul;25(3):442-460.
- doi: 10.5056/jnm19014
BACKGROUND/AIMS: Abdominal pain can be evoked or exacerbated after gastrointestinal cold stimulation in some patients with diarrhea-predominant irritable bowel syndrome (IBS-D), indicating a low temperature-induced sensitization of visceral perception. We... -
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- KIF11 Functions as an Oncogene and Is Associated with Poor Outcomes from Breast Cancer
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Zhou J, Chen WR, Yang LC, Wang J, Sun JY, Zhang WW, He ZY, Wu SG
- KMID: 2454312
- Cancer Res Treat.
- 2019 Jul;51(3):1207-1221.
- doi: 10.4143/crt.2018.460
PURPOSE: The study aimed to search and identify genes that were differentially expressed in breast cancer, and their roles in cancer growth and progression. MATERIALS AND METHODS: The Gene Expression Omnibus... -
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