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Receptor-Mediated Muscle Homeostasis as a Target for Sarcopenia Therapeutics

Yoon JH, Kwon KS

Sarcopenia is a disease characterized by age-related decline of skeletal muscle mass and function. The molecular mechanisms of the pathophysiology of sarcopenia form a complex network due to the involvement...
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Recent Advances in Understanding Peripheral Taste Decoding I: 2010 to 2020

Jang JH, Kwon O, Moon SJ, Jeong YT

Taste sensation is the gatekeeper for direct decisions on feeding behavior and evaluating the quality of food. Nutritious and beneficial substances such as sugars and amino acids are represented by...
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Zebrafish Vascular Development: General and Tissue-Specific Regulation

Nakajima H, Chiba A, Fukumoto M, Morooka N, Mochizuki N

Circulation is required for the delivery of oxygen and nutrition to tissues and organs, as well as waste collection. Therefore, the heart and vessels develop first during embryogenesis. The circulatory system...
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Four active monomers from Moutan Cortex exert inhibitoryeffects against oxidative stress by activating Nrf2/Keap1signaling pathway

Zhang B, Yu D, Luo N, Yang C, Zhu Y

Paeonol, quercetin, -sitosterol, and gallic acid extracted from MoutanCortex had been reported to possess anti-oxidative, anti-inflammatory, and antitumoractivities. This work aimed to illustrate the potential anti-oxidative mechanismof monomers in human...
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The Dose Dependent Effects of Ruxolitinib on the Invasion and Tumorigenesis in Gliomas Cells via Inhibition of Interferon Gamma-Depended JAK/STAT Signaling Pathway

Delen E, Doğanlar O

Objective : Glioblastoma multiforme (GBM) is the most aggressive for of brain tumor and treatment often fails due to the invasion of tumor cells into neighboring healthy brain tissues. Activation...
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Recent updates on the basic mechanisms and pathogenesis of inflammatory bowel diseases in experimental animal models

Mizoguchi , Low D, Ezaki Y, Okada T

The specific pathogenesis underlining inflammatory bowel disease (IBD) is very complicated, and it is further more difficult to clearly explain the pathophysiology of 2 major forms of IBD, Crohn’s disease...
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Hippo Signal Transduction Mechanisms in T Cell Immunity

Bouchard A, Mariko M, Chang J, Panneton V, Li J, Bouklouch Y, Suh WK

Hippo signaling pathways are evolutionarily conserved signal transduction mechanisms mainly involved in organ size control, tissue regeneration, and tumor suppression. However, in mammals, the primary role of Hippo signaling seems...
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Function of NADPH Oxidases in Diabetic Nephropathy and Development of Nox Inhibitors

Lee SR, An EJ, Kim J, Bae YS

Several recent studies have reported that reactive oxygen species (ROS), superoxide anion and hydrogen peroxide (H2O2), play important roles in various cellular signaling networks. NADPH oxidase (Nox) isozymes have been...
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Ezrin-radixin-moesin proteins are regulated by Akt-GSK3β signaling in the rat nucleus accumbens core

Kim WY, Cai WT, Jang JK, Kim JH

The ezrin-radixin-moesin (ERM) proteins are a family of membrane-associated proteins known to play roles in cell-shape determination as well as in signaling pathways. We have previously shown that amphetamine decreases...
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Insights into the signal transduction pathways of mouse lung type II cells revealed by transcription factor profiling in the transcriptome

Ramana CV

Alveolar type II cells constitute a small fraction of the total lung cell mass. However, they play an important role in many cellular processes including trans-differentiation into type I cells...
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New Insights into the Molecular and Cellular Mechanism of Antipsychotics

Kim SH

The serendipitous discovery of drugs with antipsychotic action has provided a clue to understanding the pathogenesis of psychotic disorders and to develop so called ‘antipsychotics’ drugs. From the ‘dopamine hypothesis’...
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Paricalcitol attenuates indoxyl sulfate-induced apoptosis through the inhibition of MAPK, Akt, and NF-κB activation in HK-2 cells

Park JS, Choi HI, Bae EH, Ma SK, Kim SW

BACKGROUND/AIMS: Indoxyl sulfate (IS) is a uremic toxin and an important causative factor in the progression of chronic kidney disease. Recently, paricalcitol (19-nor-1,25-dihydroxyvitamin D2) was shown to exhibit protective effects...
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Noncoding RNAs as therapeutic targets in early stage diabetic kidney disease

Kato M

Diabetic kidney disease (DKD) is a major renal complication of diabetes that leads to renal dysfunction and end-stage renal disease (ESRD). Major features of DKD include accumulation of extracellular matrix...
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Down-regulation of transient receptor potential melastatin member 7 prevents migration and invasion of renal cell carcinoma cells via inactivation of the Src and Akt pathway

Ha YS, Kim YY, Yu NH, Chun SY, Choi SH, Lee JN, Kim BS, Yoo ES, Kwon TG

PURPOSE: Transient receptor potential melastatin member 7 (TRPM7), an ion channel and serine/threonine protein kinase, has been linked with distinct human malignancies. However, the role of TRPM7 in renal cell...
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Regulation of Cellular Antiviral Signaling by Modifications of Ubiquitin and Ubiquitin-like Molecules

Li K, Zhong B

The initiation of cellular antiviral signaling depends on host pattern-recognition receptors (PRRs)-mediated recognition of viral nucleic acids that are known as classical pathogen-associated molecular patterns (PAMPs). PRRs recruit adaptor proteins...
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The role of p21/CIP1/WAF1 (p21) in the negative regulation of the growth hormone/growth hormone receptor and epidermal growth factor/epidermal growth factor receptor pathways, in growth hormone transduction defect

Kostopoulou E, Rojas Gil , Spiliotis

PURPOSE: Growth hormone transduction defect (GHTD) is characterized by severe short stature, impaired STAT3 (signal transducer and activator of transcription-3) phosphorylation and overexpression of the cytokine inducible SH2 containing protein...
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Low Level Light Therapy Using an 830-nm Light Emitting Diode Promotes Wound Healing via TGF-β/SMAD Pathway Activation

Kim SK, Soh BW, Kim YC

  • KMID: 2379898
  • Korean J Dermatol.
  • 2017 May;55(4):237-245.
BACKGROUND: The transforming growth factor-β/SMAD (TGF-β/SMAD) pathway plays an important role in tissue repair and collagen synthesis. Low-level light therapy (LLLT) is increasingly used to alleviate pain and inflammation and...
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In Silico Model-driven Assessment of the Effects of Brain-derived Neurotrophic Factor Deficiency on Glutamate and Gamma-Aminobutyric Acid: Implications for Understanding Schizophrenia Pathophysiology

Agrawal R, Kalmady SV, Venkatasubramanian G

OBJECTIVE: Deficient brain-derived neurotrophic factor (BDNF) is one of the important mechanisms underlying the neuroplasticity abnormalities in schizophrenia. Aberration in BDNF signaling pathways directly or circuitously influences neurotransmitters like glutamate...
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Heterogeneous Nuclear Ribonucleoprotein A2B1 Exerts a Regulatory Role in Lipopolysaccharide-stimulated 38B9 B Cell Activation

Park J, Choe CH, Kim J, Yang JS, Kim JH, Jang H, Jang YS

Major histocompatibility complex (MHC) class II molecules, which are recognized for their primary function of presenting an antigen to the T cell receptor, are involved in various signaling pathways in...
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Static magnetic fields promote osteoblastic/cementoblastic differentiation in osteoblasts, cementoblasts, and periodontal ligament cells

Kim EC, Park J, Kwon IK, Lee SW, Park SJ, Ahn SJ

PURPOSE: Although static magnetic fields (SMFs) have been used in dental prostheses and osseointegrated implants, their biological effects on osteoblastic and cementoblastic differentiation in cells involved in periodontal regeneration remain...
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