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Electrophoretic variations of enzyme, GDH (NADP-dependent glutamate dehydrogenase)(EC. 1.4.1.4) in characterizing clones and isolates of Malaysian Plasmodium falciparum

Ang HH, Chan KL, Mak JW

: Malaysian, African and Thai Plasmodium falciparum isolates were cultured in vitro by the Trager and Jensen method (1976; 1977) and were later cloned by the limiting dilution method (Rosario,...
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Novel Therapeutic Target of Non-alcoholic Fatty Liver Disease: Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2 and Reactive Oxygen Species in Pro-inflammatory Macrophages

Eun HS

No abstract available.
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Induction of NADPH oxidases and antioxidant proteins by Porphyromonas gingivalis in KB cells

Kim MJ, Chung HJ, Park BJ, Park HR, Lee TH

  • KMID: 2321614
  • J Korean Acad Periodontol.
  • 2006 Dec;36(4):863-878.
No abstract available.
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A Case of Fixed Drug Eruption Induced by Tegafur-Uracil(TEGASIL)

Heo YS, Song HJ, Oh CH

  • KMID: 2247720
  • Korean J Dermatol.
  • 2010 Feb;48(2):155-157.
A mixture of tegafur and uracil (TEGASIL) is a common antineoplastic agent. Tegafur is a fluoropyrimidine structurally similar to 5-fluorouracil (5-FU); uracil slows the degradation of 5-FU by dihydropyrimidine dehydrogenase,...
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Effect of Thiamine Deficiency on Drug Hydroxylation and Level of Cytochrome P-450 in the Rats

Kim BH, Hong YS, Sung NE

Our studies are concerned with cytochrome P-450 content and 2-acetylaminofluorene N-and ring-hydroxylation by thiamine deficient rat liver microsomes. Incubation medium contained 100mM HEPES buffer pH 7.8, 2mM NADPH, 100mM KF,...
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Role of Reactive Oxygen Species in Allergic Rhinitis

Lee SS

Among many factors explaining recent increase in the prevalence of asthma and allergic rhinitis, role of reactive oxygen species (ROS) during development of these diseases is increasingly considered. Due to...
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NADPH Diaphorase Staining Retinal Cells in Streptozotocin-induced Diabetic Rat Retina

Lee SJ, Huh K

  • KMID: 2205362
  • J Korean Ophthalmol Soc.
  • 1998 Oct;39(10):2377-2384.
Nitric oxide(NO) is a free radical which serves a wide variety of functions on vascular tone, neurotransmission, immune cytotoxicity, and many others. Nitric oxide synthase(NOS) is the biosynthetic enzyme of...
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Identification of a Novel Mutation in the CYBB Gene, p.Asp378Gly, in a Patient With X-linked Chronic Granulomatous Disease

Song SM, Park MR, Kim DS, Kim J, Kim YJ, Ki CS, Ahn K

Chronic granulomatous disease (CGD) is a rare immunodeficiency disease, which is characterized by the lack of a functional nicotinamide adenine dinucleotide phosphate (NADPH) oxidase in phagocytes. The disease presents leukocytosis,...
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Concomitant use of corticosteroid and antimicrobials for liver abscesses in patients with chronic granulomatous disease

Shin KS, Lee MS

Chronic granulomatous disease (CGD) is a rare inherited disorder caused by defective nicotinamide adenine dinucleotide phosphate oxidase enzyme and characterized by recurrent bacterial and fungal infections. Although liver abscess is...
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Novel non-apoptotic cell death: ferroptosis

Woo SM, Kwon TK

Ferroptosis is a newly recognized type of cell death that results from iron-dependent lipid peroxidation and is different from other types of cell death, such as apoptosis, necrosis, and autophagic...
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Lignans with NADPH Oxidase 2 (NOX2)-inhibitory Activity from the Fruits of Schisandra chinensis

Park JM, Pel P, Chin YW, Lee MY

An isoform of NADPH oxidase (NOX), NOX2 is a superoxide-generating enzyme involved in diverse pathophysiological events. Although its potential as a therapeutic target has been validated, there is no clinically...
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Roles of Reactive Oxygen Species on Insulin Resistance in Adipose Tissue

Han CY

Obesity resulting from the delivery of an excess amount of energy to adipose tissue from glucose or free fatty acids is associated with insulin resistance and adipose tissue inflammation. Reactive...
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Development of myenteric plexus in human foetuses: a quantitative study

Singh S, Shariff A, Roy T, Das T, Rani N

Maturation of neurons of the myenteric plexus (MP) of human fetal sigmoid colon was studied at various weeks of gestation (WG). There is abundant literature on the development of MP...
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Drug Metabolizing Enzymes and Arachidonic Acid Metabolism in Diabetic Rat Ocular Tissues

Hong YS

The metabolism of drug and arachidonic acid(AA) by diabetic rat ocular tissues was studied. Little information is available on drug metabolism enzymes in ocular tissues. I investigated the presence of...
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5-aminoimidazole-4-carboxamide Riboside Induces Apoptosis Through AMP-activated Protein Kinase-independent and NADPH Oxidase-dependent Pathways

Wi SM, Lee KY

It is debatable whether AMP-activated protein kinase (AMPK) activation is involved in anti-apoptotic or pro-apoptotic signaling. AICAR treatment increases AMPK-alpha1 phosphorylation, decreases intracellular reactive oxygen species (ROS) levels, and significantly...
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Immunohistochemical Study on the Distribution of Neuropeptide Yand NADPH-Diaphorase Positive Neurons in the Cerebral Cortex of Mice

Kim YS, Huh YB, Ahn HK

  • KMID: 2283066
  • Korean J Phys Anthropol.
  • 1998 Jun;11(1):61-71.
This study was aimed to clarify the change of neuropeptide Y -immunoreactive (NPY -IR) and NADPH -diaphorase (NADPH -d)-positive neurons associated with aging of ICR and C57Bl/6 mice. To verify...
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Autophagy in Redox Signalling

Choi TG, Kim SS

Autophagy is a major catabolic process that is involved in cellular degradation of unnecessary or dysfunctional cellular components via the lysosomal machinery. Autophagy is involved in a variety of biological...
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A Case of 5-Fluorouracil Induced Encephalopathy

Kwon KA, Kwon HC, Kim MC, Kim SH, Oh SY, Lee S, Kim HJ

  • KMID: 2165968
  • Cancer Res Treat.
  • 2010 Jun;42(2):118-120.
Patients with reduced dihydropyrimidine dehydrogenase (DPD) activity are at risk for experiencing serious adverse effects following 5-fluorouracil (5-FU) based chemotherapy. Neurotoxicity is considered an extremely rare side effect of 5-FU....
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Protective Mechanism of Glucose against Alloxan-Indeved HIT-T15 Cell Damage

Lee TH, Park TS, Kim HR

  • KMID: 2177941
  • J Korean Diabetes Assoc.
  • 1999 Aug;23(4):530-540.
BACKGROUND: Glucose prevents the development of alloxan-induced diabetes, but the precise protective mechanism of glucose is not yet clearly known. METHODS: The protective mechanism of glucose on alloxan-induced B-cell damage...
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Epigallocatechin-3-gallate Regulates NADPH Oxidase Expression in Human Umbilical Vein Endothelial Cells

Ahn HY, Kim CH, Ha TS

Vascular NADPH oxidase plays a pivotal role in producing superoxide in endothelial cells and thus acts in the initiation and development of inflammatory cardiovascular diseases such as atherosclerosis. Epigallocatechin-3-gallate (EGCG),...
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