Korean J Gastroenterol.  2018 Oct;72(4):226-227. 10.4166/kjg.2018.72.4.226.

Novel Therapeutic Target of Non-alcoholic Fatty Liver Disease: Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2 and Reactive Oxygen Species in Pro-inflammatory Macrophages

• Eun HS

• KMID: 2424117
• DOI: http://doi.org/10.4166/kjg.2018.72.4.226

Abstract

No abstract available.

MeSH Terms

Macrophages*
NAD*
NADP*
Niacinamide*
Non-alcoholic Fatty Liver Disease*
Reactive Oxygen Species*
NAD
NADP
Niacinamide
Reactive Oxygen Species

Reference

1. Kim SY, Jeong JM, Kim SJ, et al. Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4-MD2 complex. Nat Commun. 2017; 8:2247.

2. Del Ben M, Polimeni L, Carnevale R, et al. NOX2-generated oxidative stress is associated with severity of ultrasound liver steatosis in patients with non-alcoholic fatty liver disease. BMC Gastroenterol. 2014; 14:81.

3. dela Peña A, Leclercq IA, Williams J, Farrell GC. NADPH oxidase is not an essential mediator of oxidative stress or liver injury in murine MCD diet-induced steatohepatitis. J Hepatol. 2007; 46:304–313.