Korean J Otorhinolaryngol-Head Neck Surg.
2012 Sep;55(9):541-545. 10.3342/kjorl-hns.2012.55.9.541.
Role of Reactive Oxygen Species in Allergic Rhinitis
- Affiliations
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- 1Department of Otorhinolaryngology-Head and Neck Surgery, Ewha Womans University School of Medicine, Seoul, Korea. seungsin2@ewha.ac.kr
- KMID: 2141138
- DOI: http://doi.org/10.3342/kjorl-hns.2012.55.9.541
Abstract
- Among many factors explaining recent increase in the prevalence of asthma and allergic rhinitis, role of reactive oxygen species (ROS) during development of these diseases is increasingly considered. Due to their highly reactive nature, ROS produced mainly by the phagocyte nicotinamide adenine dinucleotide phosphate oxidase complex have been considered harmful mediators of inflammation for a long time. However, there are an increasing number of findings suggesting that ROS are anti-inflammatory and prevent autoimmune responses and allergic diseases, thus challenging existing dogma. ROS might not only be produced as a mechanism to eradicate invading pathogens, but rather as a means by which to fine-tune the inflammatory response, depending on when, where and at what amounts they are produced. In this review, the author aim to describe the current findings highlighting ROS as regulators of inflammation, focusing on asthma and allergic rhinitis.
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