- Recent Advances in ROS-Scavenging Metallic Nanozymes for Anti-Inflammatory Diseases: A Review
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Mohapatra A, Park IK
- KMID: 2538692
- Chonnam Med J.
- 2023 Jan;59(1):13-23.
- doi: 10.4068/cmj.2023.59.1.13
Oxidative stress and dysregulated inflammatory responses are the hallmarks of inflammatory disorders, which are key contributors to high mortality rates and impose a substantial economic burden on society. Reactive oxygen... -
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- MS-5, a Naphthalene Derivative, Induces Apoptosis in Human Pancreatic Cancer BxPC-3 Cells by Modulating Reactive Oxygen Species
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Giri S, Park GH, Choi JS, Ma E, Chun KS, Joo SH
- KMID: 2537582
- Biomol Ther.
- 2023 Jan;31(1):68-72.
- doi: 10.4062/biomolther.2022.127
Pancreatic cancer is one of the most fatal cancers with a poor prognosis. Standard chemotherapies have proven largely ineffective because of their toxicity and the development of resistance. Therefore, there... -
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- Antibacterial properties of dental resin incorporated with nano-silver doped silica in accordance with exposure of visible light
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Lee MY, Yoon HW, Kim KM, Kwon JS
- KMID: 2537864
- Korean J Dent Mater.
- 2022 Dec;49(4):161-172.
- doi: 10.14815/kjdm.2022.49.4.161
This study investigated reduction of the bandgap of silica by applying nano-silver doping technique and possible application of such silica as a filler in dental resin. Due to reduce band... -
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- Oxidative Stress and Its Relation to Lower Urinary Tract Symptoms
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Andersson KE
- KMID: 2537302
- Int Neurourol J.
- 2022 Dec;26(4):261-267.
- doi: 10.5213/inj.2244190.095
The aim of this review is to discuss how to link lower urinary tract symptoms (LUTS) and oxidative stress (OS) and to define relevant targets for therapeutic intervention. Narrative review... -
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- Clinical effectiveness and prospects of methylene blue: A systematic review
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Seitkazina A, Yang JK, Kim S
- KMID: 2538084
- Precis Future Med.
- 2022 Dec;6(4):193-208.
- doi: 10.23838/pfm.2022.00079
Methylene blue (MB) is a well-known pharmaceutical ingredient that is thought to have a multi-targeted therapeutic effect as an anti-malarial and neuroprotective agent and has recently been identified as a... -
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- Hydroxyzine Induces Cell Death in Triple-Negative Breast Cancer Cells via Mitochondrial Superoxide and Modulation of Jak2/STAT3 Signaling
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Shakya R, Park GH, Joo SH, Shim JH, Choi JS
- KMID: 2534709
- Biomol Ther.
- 2022 Nov;30(6):585-592.
- doi: 10.4062/biomolther.2022.121
Treatment of triple-negative breast cancer (TNBC) has been limited due to the lack of molecular targets. In this study, we evaluated the cytotoxicity of hydroxyzine, a histamine H1 receptor antagonist... -
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- Modulation of Reactive Oxygen Species to Overcome 5-Fluorouracil Resistance
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Chun KS, Joo SH
- KMID: 2534697
- Biomol Ther.
- 2022 Nov;30(6):479-489.
- doi: 10.4062/biomolther.2022.017
5-Fluorouracil (5-FU) remains to be an important chemotherapeutic drug for treating several cancers when targeted therapy is unavailable. Chemoresistance limits the clinical utility of 5-FU, and new strategies are required... -
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- Pathomechanism of oxidative stress in cardiovascularrenal remodeling and therapeutic strategies
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Ravarotto V, Bertoldi G, Stefanelli LF, Nalesso F, Calò LA
- KMID: 2535399
- Kidney Res Clin Pract.
- 2022 Sep;41(5):533-544.
- doi: 10.23876/j.krcp.22.069
The high prevalence of cardiovascular disease in patients with chronic kidney disease indicates significant interactions between pathogenic pathways operating in the kidney and heart. These interactions involve all cell types... -
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- The Association of Oxidative Stress and Reactive Oxygen Species Modulator 1 (ROMO1) with Infertility: A Mini Review
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Amini MA, Karimi M, Talebi SS, Piri H, Karimi J
- KMID: 2533273
- Chonnam Med J.
- 2022 Sep;58(3):91-95.
- doi: 10.4068/cmj.2022.58.3.91
Infertility is one of the disorders that worries many couples around the world, although novel and molecular methods can be used to cure this disease in different stages. One of... -
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- Epigallocatechin-3-gallate suppresses hemin-aggravated colon carcinogenesis through Nrf2-inhibited mitochondrial reactive oxygen species accumulation
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Seok JH, Kim DH, Kim HJ, Jo HH, Kim EY, Jeong JH, Park YS, Lee SH, Kim DJ, Nam SY, Lee BJ, Lee HJ
- KMID: 2533378
- J Vet Sci.
- 2022 Sep;23(5):e74.
- doi: 10.4142/jvs.22097
Background: Previous studies have presented evidence to support the significant association between red meat intake and colon cancer, suggesting that heme iron plays a key role in colon carcinogenesis. Epigallocatechin-3-gallate... -
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- NADPH oxidase inhibitor development for diabetic nephropathy through water tank model
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Lee HE, Shim S, Choi Y, Bae YS
- KMID: 2535415
- Kidney Res Clin Pract.
- 2022 Sep;41(Suppl 2):S89-S98.
- doi: 10.23876/j.krcp.21.269
Oxidative stress can cause generation of uncontrolled reactive oxygen species (ROS) and lead to cytotoxic damage to cells and tissues. Recently, it has been shown that transient ROS generation can... -
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- Comparative Study of Autophagy in Oxaliplatin-Sensitive and Resistant SNU-C5 Colon Cancer Cells
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Boo SJ, Piao MJ, Kang KA, Zhen AX, Fernando PDSM, Herath HMUL, Lee SJ, Song SE, Hyun JW
- KMID: 2532877
- Biomol Ther.
- 2022 Sep;30(5):447-454.
- doi: 10.4062/biomolther.2022.028
Few studies have evaluated the role of autophagy in the development of oxaliplatin (OXT) resistance in colon cancer cells. In this study, we compared the role of autophagy between SNU-C5... -
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- SOCS3 Attenuates DexamethasoneInduced M2 Polarization by DownRegulation of GILZ via ROS- and p38 MAPK-Dependent Pathways
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Jeong H, Yoon H, Lee Y, Kim JT, Yang M, Kim G, Jung B, Park SH, Lee CE
- KMID: 2536260
- Immune Netw.
- 2022 Aug;22(4):e33.
- doi: 10.4110/in.2022.22.e33
Suppressors of cytokine signaling (SOCS) have emerged as potential regulators of macrophage function. We have investigated mechanisms of SOCS3 action on type 2 macrophage (M2) differentiation induced by glucocorticoid using... -
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- Glycine induces enhancement of bactericidal activity of neutrophils
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Kang SH, Ham HY, Hong CW, Song DK
- KMID: 2530941
- Korean J Physiol Pharmacol.
- 2022 Jul;26(4):229-238.
- doi: kjpp.2022.26.4.229
Severe bacterial infections are frequently accompanied by depressed neutrophil functions. Thus, agents that increase the microbicidal activity of neutrophils could add to a direct antimicrobial therapy. Lysophosphatidylcholine augments neutrophil bactericidal... -
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- The relationship between reactive oxygen species, DNA fragmentation, and sperm parameters in human sperm using simplified sucrose vitrification with or without triple antioxidant supplementation
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Juanpanich T, Suttirojpattana T, Parnpai R, Vutyavanich T
- KMID: 2531713
- Clin Exp Reprod Med.
- 2022 Jun;49(2):117-126.
- doi: 10.5653/cerm.2021.05120
Objective: This study examined whether the addition of triple antioxidants (3A)—10 μM acetyl-L-carnitine, 10 μM N-acetyl-L-cysteine, and 5 μM α-lipoic acid—in freezing-thawing medium during human sperm cryopreservation using the sucrose... -
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- Induction of apoptotic cell death in human bladder cancer cells by ethanol extract of Zanthoxylum schinifolium leaf, through ROS-dependent inactivation of the PI3K/Akt signaling pathway
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Park C, Choi EO, Hwangbo H, Lee H, Jeong JW, Han MH, Moon SK, Yun SJ, Kim WJ, Kim GY, Hwang HJ, Choi YH
- KMID: 2530394
- Nutr Res Pract.
- 2022 Jun;16(3):330-343.
- doi: 10.4162/nrp.2022.16.3.330
BACKGROUND/OBJECTIVES: Zanthoxylum schinifolium is traditionally used as a spice for cooking in East Asian countries. This study was undertaken to evaluate the anti-proliferative potential of ethanol extracts of Z. schinifolium... -
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- Obesity Exacerbates Coxsackievirus Infection via Lipid-Induced Mitochondrial Reactive Oxygen Species Generation
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Kim SR, Song JH, Ahn JH, Jeong MS, Yang YM, Cho J, Jeong JH, Cha Y, Kim KN, Kim HP, Chang SY, Ko HJ
- KMID: 2536246
- Immune Netw.
- 2022 Apr;22(2):e19.
- doi: 10.4110/in.2022.22.e19
Coxsackievirus B3 (CVB3) infection causes acute pancreatitis and myocarditis. However, its pathophysiological mechanism is unclear. Here, we investigated how lipid metabolism is associated with exacerbation of CVB3 pathology using high-fat... -
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- Astaxanthin Protects Ultraviolet B-Induced Oxidative Stress and Apoptosis in Human Keratinocytes via Intrinsic Apoptotic Pathway
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Chung BY, Park SH, Yun SY, Yu DS, Lee YB
- KMID: 2527465
- Ann Dermatol.
- 2022 Apr;34(2):125-131.
- doi: 10.5021/ad.2022.34.2.125
Background: Ultraviolet radiation causes skin damage due to increased production of reactive oxygen species (ROS) and inflammatory intermediates and direct attack of DNA of skin cells. Astaxanthin is a reddish... -
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- Nanozyme-Based Enhanced Cancer Immunotherapy
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Phan NM, Nguyen TL, Kim J
- KMID: 2528121
- Tissue Eng Regen Med.
- 2022 Apr;19(2):237-252.
- doi: 10.1007/s13770-022-00430-y
Catalytic nanoparticles with natural enzyme-mimicking properties, known as nanozymes, have emerged as excellent candidate materials for cancer immunotherapy. Owing to their enzymatic activities, artificial nanozymes not only serve as responsive... -
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- N-Acetylcysteine Induces Apoptotic, Oxidative and Excitotoxic Neuronal Death in Mouse Cortical Cultures
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Hwang S, Kim JK
- KMID: 2525154
- Chonnam Med J.
- 2022 Jan;58(1):18-23.
- doi: 10.4068/cmj.2022.58.1.18
N-acetylcysteine (NAC) has been used as an antioxidant to prevent oxidative cell death. However, we found NAC itself to induce neuronal death in mouse cortical cultures. Therefore, the current study was performed... -
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