- Effect Modification of Acetaldehyde Dehydrogenase 2 rs671 Polymorphism on the Association between Alcohol Intake and Blood Pressure: the Dong-gu Study
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Kim HY, Choi CK, Kweon SS, Lee YH, Nam HS, Park KS, Ryu SY, Choi SW, Shin MH
- KMID: 2471201
- J Korean Med Sci.
- 2020 Mar;35(9):e14.
- doi: 10.3346/jkms.2020.35.e14
BACKGROUND: Elevated blood pressure is a major preventable cause of cardiovascular diseases. Alcohol consumption is a well-known risk factor of elevated blood pressure. The aldehyde dehydrogenase 2 (ALDH2) polymorphism is... -
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- 15-Deoxy-Δ(12,14)-prostaglandin J₂ Upregulates the Expression of 15-Hydroxyprostaglandin Dehydrogenase by Inducing AP-1 Activation and Heme Oxygenase-1 Expression in Human Colon Cancer Cells
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Park JM, Na HK
- KMID: 2468800
- J Cancer Prev.
- 2019 Sep;24(3):183-191.
- doi: 10.15430/JCP.2019.24.3.183
BACKGROUND: Abnormal upregulation of prostaglandin Eâ‚‚ (PGEâ‚‚) is considered to be a key oncogenic event in the development and progression of inflammation-associated human colon cancer. It has been reported that... -
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- Inhibitory Effects of Protopanaxadiol on Lipopolysaccharide-Induced Reactive Oxygen Species Production and MUC5AC Expression in Human Airway Epithelial Cells
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Song YS, Kim JH, Na H, Choi YS, Song SY, Kim YD, Bae CH
- KMID: 2461002
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2019 Sep;62(9):507-514.
- doi: 10.3342/kjorl-hns.2018.00920
BACKGROUND AND OBJECTIVES: MUC5AC is one of the major secretory mucin genes in the human airway epithelium. MUC5AC expression is increased by a variety of inflammatory mediators. Protopanaxadiol (PPD), one... -
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- Effect of Ambrisentan Therapy on the Expression of Endothelin Receptor, Endothelial Nitric Oxide Synthase and NADPH Oxidase 4 in Monocrotaline-induced Pulmonary Arterial Hypertension Rat Model
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Lee H, Yeom A, Kim KC, Hong YM
- KMID: 2455794
- Korean Circ J.
- 2019 Sep;49(9):866-876.
- doi: 10.4070/kcj.2019.0006
BACKGROUND AND OBJECTIVES: Elevated endothelin (ET)-1 level is strongly correlated with the pathogenesis of pulmonary arterial hypertension (PAH). Expression level of nicotinamide adenine dinucleotide phosphate oxidase (NOX) 4 is increased... -
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- Virulence genes of Streptococcus mutans and dental caries
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You YO
- KMID: 2452744
- Int J Oral Biol.
- 2019 Jun;44(2):31-36.
- doi: 10.11620/IJOB.2019.44.2.31
Streptococcus mutans is one of the important bacteria that forms dental biofilm and cause dental caries. Virulence genes in S. mutans can be classified into the genes involved in bacterial... -
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- Beta-carotene prevents the spermatogenic disorders induced by exogenous scrotal hyperthermia through modulations of oxidative stress, apoptosis, and androgen biosynthesis in mice
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Yon JM, Kim JS, Lin C, Park SG, Gwon LW, Lee JG, Baek IJ, Nahm SS, Nam SY
- KMID: 2451639
- Korean J Vet Res.
- 2019 Jun;59(2):59-67.
- doi: 10.14405/kjvr.2019.59.2.59
We investigated whether β-carotene (β-CA) or ellagic acid (EA), originating from various fruits and vegetables, has a preventive effect against male infertility induced by exogenous scrotal hyperthermia. ICR adult mice... -
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- Facklamia hominis Isolated from a Wound: A Case Report and Review of the Literature
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Kim TY, Jo J, Kim N, Park H, Roh EY, Yoon JH, Shin S
- KMID: 2450003
- Ann Clin Microbiol.
- 2019 Jun;22(2):50-54.
- doi: 10.5145/ACM.2019.22.2.50
Facklamia hominis is a facultative anaerobic Gram-positive coccus generally displaying weak alpha-hemolysis and negativity for catalase and oxidase. Facklamia species are part of the normal flora of the female genitourinary... -
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- Effect of Ginkgo Biloba Extract on N-Methyl-D-Aspartic Acid Receptor Subunit 2B Expression in a Salicylate-Induced Ototoxicity Model
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Lee SY, Han SY, Shim YJ, Han JJ, Cho D, Kim JE, Kim YH
- KMID: 2447425
- Clin Exp Otorhinolaryngol.
- 2019 May;12(2):169-175.
- doi: 10.21053/ceo.2018.00983
OBJECTIVES.: Sodium salicylate (SS) is well known for its ototoxic properties that induce functional and morphological changes in the cochlea and brain. Ginkgo biloba extract (GBE) has been widely used... -
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- Cytochrome C Oxidase Subunit 1, Internal Transcribed Spacer 1, Nicotinamide Adenine Dinucleotide Hydrogen Dehydrogenase Subunits 2 and 5 of Clonorchis sinensis Ancient DNA Retrieved from Joseon Dynasty Mummy Specimens
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Hong JH, Oh CS, Chai JY, Seo M, Shin DH
- KMID: 2447038
- J Korean Med Sci.
- 2019 May;34(20):e149.
- doi: 10.3346/jkms.2019.34.e149
We analyzed Clonorchis sinensis ancient DNA (aDNA) acquired from the specimens of the Joseon mummies. The target regions were cytochrome C oxidase subunit 1 (CO1), internal transcribed spacer 1 (ITS1),... -
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- Effects of heme oxygenase-1 upregulation on isoproterenol-induced myocardial infarction
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Eltobshy S, Hussein AM, Elmileegy , Askar MH, Khater Y, Metias EF, Helal GM
- KMID: 2443608
- Korean J Physiol Pharmacol.
- 2019 May;23(3):203-217.
- doi: 10.4196/kjpp.2019.23.3.203
The present study was designed to examine the effect of heme oxygenase-1 (HO-1) induction by cobalt protoporphyrin (CoPP) on the cardiac functions and morphology, electrocardiogram (ECG) changes, myocardial antioxidants (superoxide... -
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- Persistent Erectile Dysfunction after Discontinuation of 5-Alpha Reductase Inhibitor Therapy in Rats Depending on the Duration of Treatment
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Sung HH, Yu J, Kang SJ, Chae MR, So I, Park JK, Lee SW
- KMID: 2443240
- World J Mens Health.
- 2019 May;37(2):240-248.
- doi: 10.5534/wjmh.180082
PURPOSE: The current study is aimed to assess whether a longer duration of 5α-reductase inhibitor (5α-RI) exposure was associated with higher rate of permanent erectile dysfunction (ED) in a rat... -
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- Finasteride and Erectile Dysfunction in Patients with Benign Prostatic Hyperplasia or Male Androgenetic Alopecia
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Shin YS, Karna KK, Choi BR, Park JK
- KMID: 2443231
- World J Mens Health.
- 2019 May;37(2):157-165.
- doi: 10.5534/wjmh.180029
Finasteride is primarily used to treat benign prostatic hyperplasia (BPH) and male androgenetic alopecia (MAA). Five-alpha reductase inhibitors (5α-RIs) could induce male sexual dysfunction due to their effects on testosterone... -
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- Comparison of the Effectiveness in the Application of Competitive and Noncompetitive Internal Control for the Laboratory Developed Polymerase Chain Reaction
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Shin S, Kang JW, Kang JW, Seo YI, Min H
- KMID: 2457203
- Korean J Blood Transfus.
- 2019 Apr;30(1):57-64.
- doi: 10.17945/kjbt.2019.30.1.57
BACKGROUND: A nucleic acid amplification test was adopted to detect transfusion-transmitted infectious agents. In the case of HTLV, however, there was no internal control (IC) because the laboratory developed polymerase... -
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- A New Record and Characterization of Asparagus Purple Spot Caused by Stemphylium vesicarium in Korea
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Han JH, Shin JH, Fu T, Kim KS
- KMID: 2455607
- Mycobiology.
- 2019 Mar;47(1):120-125.
- doi: 10.1080/12298093.2018.1561238
In 2017, small, elliptical, brownish purple spots on spears and ferns of asparagus were found in fields of Gangwon-do. The isolated fungal species was identified as an ascomycete Stemphylium vesicarium... -
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- An Enzymolysis-Assisted Agrobacterium tumefaciens-Mediated Transformation Method for the Yeast-Like Cells of Tremella fuciformis
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Wang Y, Xu D, Sun X, Zheng L, Chen L, Ma A
- KMID: 2455600
- Mycobiology.
- 2019 Mar;47(1):59-65.
- doi: 10.1080/12298093.2018.1559121
Agrobacterium tumefaciens-mediated transformation (ATMT), as a simple and versatile method, achieves successful transformation in the yeast-like cells (YLCs) of Tremella fuciformis with lower efficiency. Establishment of a more efficient transformation... -
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- Antioxidant, Anti-Melanogenic and Anti-Wrinkle Effects of Phellinus vaninii
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Im KH, Baek SA, Choi J, Lee TS
- KMID: 2470182
- Mycobiology.
- 2019 Dec;47(4):494-505.
- doi: 10.1080/12298093.2019.1673595
In this study, the antioxidant, anti-xanthine oxidase, anti-melanogenic and anti-wrinkle effects of methanol (ME) and hot water (HE) extracts from the fruiting bodies of Phellinus vaninii were investigated. The 1,1-diphenyl-2-picryl-hydrazyl... -
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- Anti-Helicobacter pylori, Anti-apoptotic, and Cytoprotective Effects of Threonine Synthesized from Corynebacterium glutamicum in Gastric Epithelial Cells
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An JM, Kim YS, Hong YG, Hah BS, Sohn MS, Hahm KB
- KMID: 2469316
- Korean J Helicobacter Up Gastrointest Res.
- 2019 Dec;19(4):245-256.
- doi: 10.7704/kjhugr.2019.0011
BACKGROUND/AIMS: Among irritants causing gastric ulcer, Helicobacter pylori (H. pylori) might be pivotal, after which eradication became essential way in either inhibiting ulcerogenesis or preventing ulcer recurrence. Since threonine is... -
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- Potential biomarkers and antagonists for fluoranthene-induced cellular toxicity of bone marrow derived mesenchymal stem cells
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Hoque MM, Lee YE, Kim HR, Shin MG
- KMID: 2466590
- Blood Res.
- 2019 Dec;54(4):253-261.
- doi: 10.5045/br.2019.54.4.253
BACKGROUND: Fluoranthene (FR) is a common environmental pollutant that exists in a complex mixture with other polycyclic aromatic hydrocarbons (PAHs). We identified biomarkers for monitoring FR exposure and investigated the... -
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- Implementation of a Targeted Next-Generation Sequencing Panel for Constitutional Newborn Screening in High-Risk Neonates
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Lee H, Lim J, Shin JE, Eun HS, Park MS, Park KI, Namgung R, Lee JS
- KMID: 2460223
- Yonsei Med J.
- 2019 Nov;60(11):1061-1066.
- doi: 10.3349/ymj.2019.60.11.1061
PURPOSE: Newborn screening (NBS) programs are important for appropriate management of susceptible neonates to prevent serious clinical problems. Neonates admitted to neonatal intensive care units (NICU) are at a potentially... -
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- Gamma-tocopherol ameliorates hyperglycemia-induced hepatic inflammation associated with NLRP3 inflammasome in alloxan-induced diabetic mice
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Lee H, Lim Y
- KMID: 2464116
- Nutr Res Pract.
- 2019 Oct;13(5):377-383.
- doi: 10.4162/nrp.2019.13.5.377
BACKGROUND/OBJECTIVES: Hyperglycemia-induced hepatic damage has been recognized as one of the major cause of complications in diabetes. Hepatic complications are associated with inflammation and oxidative stress in diabetes. In this... -
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