World J Mens Health.  2013 Aug;31(2):136-140.

The Role of Androgen in the Adipose Tissue of Males

• Lee HK
• Lee JK
• Cho B

Abstract

Adipose tissue, where various metabolic hormones are secreted, plays a role in metabolizing different substances including androgen. Within fat tissue, enzymes such as aromatase and aldo-keto reductase 1C are responsible for metabolizing testosterone into estrogen and 5-dihydrotestosterone into inactive metabolites. Adipose tissue can also affect the secretion of gonadotropin, which influences the formation of androgen in the testes. At the same time, androgen has an impact on the distribution and proliferation of adipose tissue. The adrenoreceptors for catecholamines, which have been proven to play an essential role in controlling lipolysis, function by being up-regulated by androgens. Furthermore, androgens regulate the activity of lipoprotein lipase, a key enzyme involved in intracellular esterification of adipose tissue.

Keyword

Androgens; Testosterone; Adipose tissue

MeSH Terms

Adipose Tissue
Alcohol Oxidoreductases
Androgens
Aromatase
Catecholamines
Esterification
Estrogens
Gonadotropins
Humans
Lipolysis
Lipoprotein Lipase
Male
Oxidoreductases
Testis
Testosterone
Alcohol Oxidoreductases
Androgens
Aromatase
Catecholamines
Estrogens
Gonadotropins
Lipoprotein Lipase
Oxidoreductases
Testosterone

Figure

• 

  Fig. 1 Interplay between adipocyte and androgen. AR: adrenoreceptor, LPL: lipo-protein lipase, TG: triglyceride, ARO: aromatase, DHT: dihydrotestosterone, AKR1C: Aldo-keto-reductase 1C.

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