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MicroRNA-138 Suppresses Adipogenic Differentiation in Human Adipose Tissue-Derived Mesenchymal Stem Cells by Targeting Lipoprotein Lipase

Wang Y, Lin L, Huang Y, Sun J, Wang X, Wang P

PURPOSE: Adipogenic differentiation of adipose tissue-derived mesenchymal stem cells (AMSCs) is critical to many disease-related disorders, such as obesity and diabetes. Studies have demonstrated that miRNA-138 (miR-138) is closely involved...
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Fumigaclavine C attenuates adipogenesis in 3T3-L1 adipocytes and ameliorates lipid accumulation in high-fat diet-induced obese mice

Yu WG, He Y, Chen YF, Gao XY, Ning WE, Liu CY, Tang TF, Liu Q, Huang XC

Fumigaclavine C (FC), an active indole alkaloid, is obtained from endophytic Aspergillus terreus (strain No. FC118) by the root of Rhizophora stylosa (Rhizophoraceae). This study is designed to evaluate whether...
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Blood Sugar Control and Low-Carbohydrate High-Fat Diet

Kang EH

Diabetes patients and pre-diabetic patients are increasing worldwide. Type 2 diabetes starts with insulin resistance, and the long-term habit of stimulating insulin secretions causes insulin resistance and accumulates body fat...
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Triglyceride-Rich Lipoproteins and Novel Targets for Anti-atherosclerotic Therapy

Reiner Z

Although elevated serum low-density lipoprotein-cholesterol (LDL-C) is without any doubts accepted as an important risk factor for cardiovascular disease (CVD), the role of elevated triglycerides (TGs)-rich lipoproteins as an independent...
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Platycodi radix beverage ameliorates postprandial lipemia response through lipid clearance of triglyceride-rich lipoprotein: A randomized controlled study in healthy subjects with a high-fat load

Lee H, Lim Y, Park SY, Cho SM, Choe JS, Jeong S, Kwak JS, Kwon O

BACKGROUND/OBJECTIVES: Elevation of postprandial lipemia characterized by a rise in triglyceride (TG)-rich lipoproteins can increase the risk of atherogenesis. The objective of this study was to investigate postprandial lipemia response...
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LPL gene Pvu II polymorphism and hypertriglyceridemia: a meta-analysis involving 1,640 subjects

Li YY, Zhou YH, Gong G, Geng HY, Yang XX, Wang XM, Zhou CW, Xu J, Qian Y

BACKGROUND/AIMS: Although lipoprotein lipase (LPL) gene Pvu II polymorphism has been associated with an increased risk of hypertriglyceridemia (HT), there is no clear consensus within the scientific community. METHODS: A meta-analysis...
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Homozygous LPL p.Gly188Glu Mutation in a Mexican Girl With Lipoprotein Lipase Deficiency

Colima Fausto AG, González García JR, Hernández Flores TDJ, Vázquez Cárdenas NA, Solís Perales NE, Magaña Torres MT

No abstract available.
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A 1-month-old infant with chylomicronemia due to GPIHBP1 gene mutation treated by plasmapheresis

Jung MK, Jin J, Kim HO, Kwon A, Chae HW, Kang SJ, Kim DH, Kim HS

Chylomicronemia is a severe type of hypertriglyceridemia characterized by chylomicron accumulation that arises from a genetic defect in intravascular lipolysis. It requires urgent and proper management, because serious cases can...
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Expression Levels of GABA-A Receptor Subunit Alpha 3, Gabra3 and Lipoprotein Lipase, Lpl Are Associated with the Susceptibility to Acetaminophen-Induced Hepatotoxicity

Kim M, Yun JW, Shin K, Cho Y, Yang M, Nam KT, Lim KM

Drug-induced liver injury (DILI) is the serious and fatal drug-associated adverse effect, but its incidence is very low and individual variation in severity is substantial. Acetaminophen (APAP)-induced liver injury accounts...
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High maysin corn silk extract reduces body weight and fat deposition in C57BL/6J mice fed high-fat diets

Lee EY, Kim SL, Kang HJ, Kim MH, Ha AW, Kim WK

BACKGROUNG/OBJECTIVES: The study was performed to investigate the effects and mechanisms of action of high maysin corn silk extract on body weight and fat deposition in experimental animals. MATERIALS/METHODS: A total...
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Effect of Glucagon-like Peptide-1 on the Differentiation of Adipose-derived Stem Cells into Osteoblasts and Adipocytes

Lee HM, Joo BS, Lee CH, Kim HY, Ock JH, Lee YS

OBJECTIVES: Glucagon-like peptide-1 (GLP-1) is an intestinally secreted hormone and it plays an important role in the regulation of glucose homeostasis. However, the possible role of GLP-1 in the differentiation...
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A study of the lipoprotein lipase inhibitory mechanism of Poncirus trifoliata water extracts

Lee SM, Kang YH, Kim KK, Kim TW, Choe M

PURPOSE: Poncirus trifoliata has been reported to have anti-inflammatory, antioxidant, and immune activities. However, its anti-obesity activity and the mechanism by which the water extract of dried, immature fruit of...
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Arctiin inhibits adipogenesis in 3T3-L1 cells and decreases adiposity and body weight in mice fed a high-fat diet

Min B, Lee H, Song JH, Han MJ, Chung J

BACKGROUND/OBJECTIVES: The purpose of this study was to examine the effects and associated mechanisms of arctiin, a lignan compound found in burdock, on adipogenesis in 3T3-L1 cells. Also, the effects...
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Fenofibrate Therapy and Change of Renal Function: Management, What and How?

Kim SH

  • KMID: 2269333
  • Korean J Med.
  • 2014 Jun;86(6):698-701.
Fenofibrate is one of PPAR-alpha (peroxisome proliferator activated receptor alpha) agonists. Fenofibrate decreases effectively triglyceride and increases high density lipoprotein cholesterol level through the effect on lipoprotein lipase, hepatic production...
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Adipogenesis of Sprague Dawely rats mesenchymal stem cells: a morphological, immunophenotyping and gene expression follow-up study

Sobh MA

Mesenchymal stem cells (MSCs) offer significant promise as a multipotent source for cell-based therapies and could form the basis for the differentiation and cultivation of tissue grafts to replace damaged...
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Gestational hyperlipidemia and acute pancreatitis with underlying partial lipoprotein lipase deficiency and apolipoprotein E3/E2 genotype

Han DH, Moh IH, Kim DM, Ihm SH, Choi MG, Yoo HJ, Hong EG

We report the case of a patient who experienced extreme recurrent gestational hyperlipidemia. She was diagnosed with partial lipoprotein lipase (LPL) deficiency but without an associated LPL gene mutation in...
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The Role of Androgen in the Adipose Tissue of Males

Lee HK, Lee JK, Cho B

  • KMID: 2320841
  • World J Mens Health.
  • 2013 Aug;31(2):136-140.
Adipose tissue, where various metabolic hormones are secreted, plays a role in metabolizing different substances including androgen. Within fat tissue, enzymes such as aromatase and aldo-keto reductase 1C are responsible...
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Clinical Factors Affecting Lipid Metabolism and Optimal Dose of Heparin in Preterm Infants on Parenteral Nutrition

Lim MS, Choi CW, Kim BI, Yang HR

  • KMID: 2315415
  • Pediatr Gastroenterol Hepatol Nutr.
  • 2013 Jun;16(2):116-122.
PURPOSE: Preterm infants on parenteral nutrition are at a relatively high risk for hypertriglyceridemia because they have immature lipoprotein lipase activity. The purpose of this study was to analyze the...
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Inhibitory effects of Capsicum annuum L. water extracts on lipoprotein lipase activity in 3T3-L1 cells

Baek J, Lee J, Kim K, Kim T, Kim D, Kim C, Tsutomu K, Ochir S, Lee K, Park CH, Lee YJ, Choe M

  • KMID: 2391960
  • Nutr Res Pract.
  • 2013 Apr;7(2):96-102.
Obesity, an intractable metabolic disease, currently has no medical treatment without side effects, so studies have been actively carried out to find natural compounds that have anti-obesity activity with minimum...
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Interaction Effects of Lipoprotein Lipase Polymorphisms with Lifestyle on Lipid Levels in a Korean Population: A Cross-sectional Study

Pyun JA, Kim S, Park K, Baik I, Cho NH, Koh I, Lee JY, Cho YS, Kim YJ, Go MJ, Shim E, Kwack K, Shin C

Lipoprotein lipase (LPL) plays an essential role in the regulation of high-density lipoprotein cholesterol (HDLC) and triglyceride levels, which have been closely associated with cardiovascular diseases. Genetic studies in European...
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