J Korean Neurol Assoc.  1999 May;17(3):340-346.

Association of Lipoprotein Lipase Gene Polymorphisms with Plasma Lipids in Ischemic Stroke Patients

• Kim JM
• Kim J
• Song HJ

Abstract

BACKGROUND: Lipoprotein lipase (LPL) is a key enzyme in the processing of triglycerides and plays a central role in lipid metabolism. It has been reported that the polymorphisms in the LPL gene were associated with plasma concentra-tions of HDL cholesterol (HDL) and triglycerides (TG) in coronary heart disease. We evaluated the correlation between the LPL gene polymorphisms and blood lipids in ischemic stroke patients.
METHODS
Ninety-six ischemic stroke patients and 88 controls were included in the study. We evaluated polymorphic sites in the LPL gene using the HindIII for the intron 8 and PvuII for the intron 6 to the polymerase chain reaction products in each group. Allele frequencies, polymorphism information contents (PIC), heterozygosity indices of HindIII and PvuII polymorphisms were calculated in each group. Correlations of total cholesterol, HDL cholesterol, TG, and LDL cholesterol levels in the serum with the HindIII and PvuII polymorphisms of the LPL gene were analyzed in each group.
RESULTS
The H+ frequencies, 0.786 and 0.752, in the stroke and control groups respectively. The P+ frequencies were 0.623 and 0.710 in stroke and control groups respectively. No significant difference was observed in triglyceride, total cholesterol, HDL, and LDL.
CONCLUSIONS
These findings suggest that the HindIII and PvuII polymorphisms in LPL gene may not be associated with the occurrence of ischemic stroke.

Keyword

Lipoprotein lipase; LPL gene polymorphisms; Ischemic stroke; Triglyceride; LDL-cholesterol; HDL-cholesterol

MeSH Terms

Cholesterol
Cholesterol, HDL
Cholesterol, LDL
Coronary Disease
Gene Frequency
Humans
Introns
Lipid Metabolism
Lipoprotein Lipase*
Lipoproteins*
Plasma*
Polymerase Chain Reaction
Stroke*
Triglycerides
Cholesterol
Cholesterol, HDL
Cholesterol, LDL
Lipoprotein Lipase
Lipoproteins
Triglycerides