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Neuroprotective Effects of GV1001 in Animal Stroke Model and Neural Cells Subject to Oxygen-Glucose Deprivation/Reperfusion Injury

Kwon HS, Kim YE, Park HH, Son JW, Choi H, Lee YJ, Kim HY, Lee KY, Koh SH

Background and Purpose Previous studies have revealed the diverse neuroprotective effects of GV1001. In this study, we investigated the effects of GV1001 on focal cerebral ischemia-reperfusion injury (IRI) in rats...
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Stroke Etiology and Outcomes after Endovascular Thrombectomy: Results from the SITS Registry and a Meta-Analysis

Matusevicius M, Cooray C, Rand VM, Nunes AP, Moreira T, Tassi R, Egido JA, Ollikainen J, Bigliardi G, Holmin S, Ahmed N

Background and Purpose The influence of stroke etiology on outcomes after endovascular thrombectomy (EVT) is not well understood. We aimed to investigate whether stroke etiology subgrouped as large artery atherosclerosis...
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Impact of Multiphase Computed Tomography Angiography for Endovascular Treatment Decision-Making on Outcomes in Patients with Acute Ischemic Stroke

Ospel JM, Volny O, Qiu W, Najm M, Hafeez M, Abdalrahman S, Fainardi E, Rubiera M, Khaw A, Shankar JJ, Hill MD, Almekhlafi MA, Demchuk AM, Goyal M, Menon BK

Background and Purpose Various imaging paradigms are used for endovascular treatment (EVT) decision-making and outcome estimation in acute ischemic stroke (AIS). We aim to compare how these imaging paradigms perform...
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Mechanical Thrombectomy in Patients with a Large Ischemic Volume at Presentation: Systematic Review and Meta-Analysis

Kerleroux B, Janot K, Hak JF, Kaesmacher J, Hassen WB, Benzakoun J, Oppenheim C, Herbreteau D, Ifergan H, Bricout N, Henon H, Yoshimoto T, Inoue M, Consoli A, Costalat V, Naggara O, Lapergue B, Cagnazzo F, Boulouis G

The benefits of mechanical thrombectomy (MT) for patients with acute ischemic stroke (AIS) and a large ischemic core (LIC) at presentation are uncertain. We aimed to obtain up-to-date aggregate estimates...
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Hemodynamics of Leptomeningeal Collaterals after Large Vessel Occlusion and Blood Pressure Management with Endovascular Treatment

Kim BJ, Singh N, Menon BK

Endovascular therapy (EVT) is an effective treatment for ischemic stroke due to large vessel occlusion (LVO). Unlike intravenous thrombolysis, EVT enables visualization of the restoration of blood flow, also known...
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Clot Composition Analysis as a Diagnostic Tool to Gain Insight into Ischemic Stroke Etiology: A Systematic Review

Aliena-Valero A, Baixauli-Martín J, Torregrosa G, Tembl JI, Salom JB

Mechanical thrombectomy renders the occluding clot available for analysis. Insights into thrombus composition could help establish the stroke cause. We aimed to investigate the value of clot composition analysis as...
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Mechanisms of Preconditioning Exercise-Induced Neurovascular Protection in Stroke

Hafez S, Eid Z, Alabasi S, Darwiche Y, Channaoui S, Hess DC

Ischemic stroke is a leading cause of death and disability. Tissue plasminogen activator is the only U.S. Food and Drug Administration approved thrombolytic therapy for ischemic stroke patients till date....
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Association of Parkinson’s disease with ischemic stroke in Korea: A nationwide longitudinal cohort study in Korea

Kim WY, Kim H, Hong JB, Sheen SH, Han Ib, Sohn S

Objective: The aim of this nationwide age- and sex- matched longitudinal follow up study is to determine the risk of Parkinson’s disease (PD) associated with ischemic stroke in Korea. Methods: Patient...
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Aspiration-Retriever Technique for Stroke with Large Bore Intermediate Catheter : A Single Center Experience

Nam JW, Jung NY, Park ES, Kwon SC

Objective : Early successful reperfusion is associated with favorable outcomes in acute ischemic stroke (AIS). The purpose of this study was to achieve successful recanalization by a combined mechanical thrombectomy...
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Risk Factors and Clinical Outcomes of Brain Reperfusion Injury after Mechanical Thrombectomy for Ischemic Stroke

Moon JH, Choi HR

Purpose: The aim of this study was to investigate the risk factors for brain reperfusion injury in ischemic stroke patients and to analyze the clinical outcomes. Methods: A retrospective study...
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Cyclophosphamide-Associated Reversible Cerebral Vasoconstriction Syndrome Presenting as Concurrent Cerebral Infarction and Subarachnoid Hemorrhage

Jeong DY, Kim KW, Park YJ, Kim YJ, Chang JY

Reversible cerebral vasoconstriction syndrome (RCVS) has several trigger factors, including physical exertion, pregnancy, and the intake of vasoconstrictive agents. These triggers activate the sympathetic nervous system and induce vasoconstriction, thereby...
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Association between Plasma Osmolality and Case Fatality within 1 Year after Severe Acute Ischemic Stroke

Liu M, Deng Y, Cheng Y, Hao Z, Wu S, Liu M

Purpose: Plasma osmolality, a marker of dehydration, is associated with cardiovascular mortality. We aimed to investigate whether elevated plasma osmolality is associated with case fatality within 1 year after severe...
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Blood-brain barrier dysfunction in ischemic stroke and diabetes: the underlying link, mechanisms and future possible therapeutic targets

Wicha P, Das S, Mahakkanukrauh P

Ischemic stroke caused by occlusion of cerebral artery is responsible for the majority of stroke that increases the morbidity and mortality worldwide. Diabetes mellitus (DM) is a crucial risk factor...
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Pneumococcal meningitis complicated by otomastoiditis and pneumocephalus confounding an acute ischemic stroke diagnosis

Malinovic M, Peterson J, Lee F

Background: Approximately one-fourth of admissions to stroke centers are diagnosed with non-stroke conditions or stroke mimics. Differentiating between these diagnoses and acute ischemic stroke is an important and time-sensitive task....
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Role of continuous hypertonic saline in acute ischemic infarcts: a systematic literature review

Chugh AJS, Maynard M, Sunshine K, Shammassian BH, Sauer A, Odetoyinbo K, Hoffer SA

Continuous hypertonic saline for hemispheric ischemic infarcts has been routinely used in neurocritical centers for the management of malignant cerebral edema. However, the data supporting its use are extremely limited....
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Long-Term Changes in Post-Stroke Depression, Emotional Incontinence, and Anger

Kwon B, Lee EJ, Park S, Lee JS, Lee MH, Jeong D, Lee D, Kwon HS, Chang DI, Park JH, Cha JK, Heo JH, Sohn SI, Kim DE, Choi-Kwon S, Kim JS

Background and Purpose Long-term changes in post-stroke depression (PSD), post-stroke emotional incontinence (PSEI), and post-stroke anger (PSA) have rarely been studied. Methods This is a sub-study of EMOTION, a randomized, placebo-controlled...
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Stroke Recurrence in First-Ever Symptomatic Carotid Web: A Cohort Study

Olindo S, Chausson N, Signate A, Mecharles S, Hennequin JL, Saint-Vil M, Edimonana-Kaptue M, Jeannin S, Landais A, Cabre P, Sibon I, Smadja D, Joux J

Background and Purpose Carotid web (CaW) is an intimal variant of fibromuscular dysplasia responsible for ipsilateral cerebral ischemic events (CIE). Symptomatic CaW likely has a high risk of recurrent CIE,...
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Automated Prediction of Ischemic Brain Tissue Fate from Multiphase Computed Tomographic Angiography in Patients with Acute Ischemic Stroke Using Machine Learning

Qiu W, Kuang H, Ospel JM, Hill MD, Demchuk AM, Goyal M, Menon BK

Background and Purpose Multiphase computed tomographic angiography (mCTA) provides time variant images of pial vasculature supplying brain in patients with acute ischemic stroke (AIS). To develop a machine learning (ML)...
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Upregulation of miR-20b Protects Against Cerebral Ischemic Stroke by Targeting Thioredoxin Interacting Protein (TXNIP)

Yang D, Tan Y, Li H, Zhang X, Li X, Zhou F

  • KMID: 2515815
  • Exp Neurobiol.
  • 2021 Apr;30(2):170-182.
  • doi: 10.5607/en20046
Dysregulation of microRNAs (miRNAs) is involved in abnormal development and pathophysiology in the brain. Although miR-20b plays essential roles in various human diseases, its function in cerebral ischemic stroke remains...
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Dynamics of T Lymphocyte between the Periphery and the Brain from the Acute to the Chronic Phase Following Ischemic Stroke in Mice

Kim M, Kim SD, Kim KI, Jeon EH, Kim MG, Lim YR, Lkhagva-Yondon E, Oh Y, Na K, Chung YC, Jin BK, Song YS, Jeon MS

  • KMID: 2515814
  • Exp Neurobiol.
  • 2021 Apr;30(2):155-169.
  • doi: 10.5607/en20062
Stroke causes systemic immunosuppression. T lymphocytes are involved in infarct size in the early stages of stroke. However, the phenotypes of T lymphocytes and their functions in peripheral immune organs...
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Copyright © 2021 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr