- MicroRNA-138 Suppresses Adipogenic Differentiation in Human Adipose Tissue-Derived Mesenchymal Stem Cells by Targeting Lipoprotein Lipase
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Wang Y, Lin L, Huang Y, Sun J, Wang X, Wang P
- KMID: 2463798
- Yonsei Med J.
- 2019 Dec;60(12):1187-1194.
- doi: 10.3349/ymj.2019.60.12.1187
PURPOSE: Adipogenic differentiation of adipose tissue-derived mesenchymal stem cells (AMSCs) is critical to many disease-related disorders, such as obesity and diabetes. Studies have demonstrated that miRNA-138 (miR-138) is closely involved... -
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- Blood Sugar Control and Low-Carbohydrate High-Fat Diet
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Kang EH
- KMID: 2442363
- J Korean Diabetes.
- 2018 Dec;19(4):237-245.
- doi: 10.4093/jkd.2018.19.4.237
Diabetes patients and pre-diabetic patients are increasing worldwide. Type 2 diabetes starts with insulin resistance, and the long-term habit of stimulating insulin secretions causes insulin resistance and accumulates body fat... -
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- LPL gene Pvu II polymorphism and hypertriglyceridemia: a meta-analysis involving 1,640 subjects
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Li YY, Zhou YH, Gong G, Geng HY, Yang XX, Wang XM, Zhou CW, Xu J, Qian Y
- KMID: 2396761
- Korean J Intern Med.
- 2017 Nov;32(6):1018-1024.
- doi: 10.3904/kjim.2016.043
BACKGROUND/AIMS: Although lipoprotein lipase (LPL) gene Pvu II polymorphism has been associated with an increased risk of hypertriglyceridemia (HT), there is no clear consensus within the scientific community. METHODS: A meta-analysis... -
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- Expression Levels of GABA-A Receptor Subunit Alpha 3, Gabra3 and Lipoprotein Lipase, Lpl Are Associated with the Susceptibility to Acetaminophen-Induced Hepatotoxicity
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Kim M, Yun JW, Shin K, Cho Y, Yang M, Nam KT, Lim KM
- KMID: 2375030
- Biomol Ther.
- 2017 Mar;25(2):112-121.
- doi: 10.4062/biomolther.2016.076
Drug-induced liver injury (DILI) is the serious and fatal drug-associated adverse effect, but its incidence is very low and individual variation in severity is substantial. Acetaminophen (APAP)-induced liver injury accounts... -
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- A study of the lipoprotein lipase inhibitory mechanism of Poncirus trifoliata water extracts
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Lee SM, Kang YH, Kim KK, Kim TW, Choe M
- KMID: 2327172
- J Nutr Health.
- 2015 Feb;48(1):9-18.
- doi: 10.4163/jnh.2015.48.1.9
PURPOSE: Poncirus trifoliata has been reported to have anti-inflammatory, antioxidant, and immune activities. However, its anti-obesity activity and the mechanism by which the water extract of dried, immature fruit of... -
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- Gestational hyperlipidemia and acute pancreatitis with underlying partial lipoprotein lipase deficiency and apolipoprotein E3/E2 genotype
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Han DH, Moh IH, Kim DM, Ihm SH, Choi MG, Yoo HJ, Hong EG
- KMID: 1780111
- Korean J Intern Med.
- 2013 Sep;28(5):609-613.
- doi: 10.3904/kjim.2013.28.5.609
We report the case of a patient who experienced extreme recurrent gestational hyperlipidemia. She was diagnosed with partial lipoprotein lipase (LPL) deficiency but without an associated LPL gene mutation in... -
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- Inhibitory effects of Capsicum annuum L. water extracts on lipoprotein lipase activity in 3T3-L1 cells
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Baek J, Lee J, Kim K, Kim T, Kim D, Kim C, Tsutomu K, Ochir S, Lee K, Park CH, Lee YJ, Choe M
- KMID: 2391960
- Nutr Res Pract.
- 2013 Apr;7(2):96-102.
Obesity, an intractable metabolic disease, currently has no medical treatment without side effects, so studies have been actively carried out to find natural compounds that have anti-obesity activity with minimum... -
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- Interaction Effects of Lipoprotein Lipase Polymorphisms with Lifestyle on Lipid Levels in a Korean Population: A Cross-sectional Study
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Pyun JA, Kim S, Park K, Baik I, Cho NH, Koh I, Lee JY, Cho YS, Kim YJ, Go MJ, Shim E, Kwack K, Shin C
- KMID: 2166490
- Genomics Inform.
- 2012 Jun;10(2):88-98.
- doi: 10.5808/GI.2012.10.2.88
Lipoprotein lipase (LPL) plays an essential role in the regulation of high-density lipoprotein cholesterol (HDLC) and triglyceride levels, which have been closely associated with cardiovascular diseases. Genetic studies in European... -
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- A Case of Lipoprotein Lipase Deficiency inan Infant with Recurrent Pancreatitis
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Park HJ, Choi BS, Yang HR, Chang JY, Ko JS, Shin CH, Yang SW, Seo JK
- KMID: 2037379
- Korean J Pediatr Gastroenterol Nutr.
- 2009 Mar;12(1):79-83.
Familial chylomicronemia syndrome is a rare disorder characterized by severe hypertriglyceridemia and fasting chylomicronemia. Causes of the syndrome include lipoprotein lipase (LPL) deficiency, apolipoprotein C-II deficiency, or the presence of... -
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- Association of lipoprotein lipase (LPL) single nucleotide polymorphisms with type 2 diabetes mellitus
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Cho YS, Go MJ, Han HR, Cha SH, Kim HT, Min H, Shin HD, Park C, Han BG, Cho NH, Shin C, Kimm K, Oh B
- KMID: 1104806
- Exp Mol Med.
- 2008 Oct;40(5):523-532.
- doi: 10.3858/emm.2008.40.5.523
The etiology and pathogenesis of type 2 diabetes mellitus (T2DM) are not completely understood although it is often associated with other conditions such as obesity, hypertension, and dyslipidemia. Lipoprotein lipase... -
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- Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte
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Choi BH, Ahn IS, Kim YH, Park JW, Lee SY, Hyun CK, Do MS
- KMID: 1115937
- Exp Mol Med.
- 2006 Dec;38(6):599-605.
Berberine (BBR), an isoquinoline alkaloid, has a wide range of pharmacological effects, yet its exact mechanism is unknown. In order to understand the anti-adipogenic effect of BBR, we studied the... -
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- Association between Low-Density Lipoprotein Subclasses and Lipoprotein Lipase Gene Polymorphisms in Coronary Artery Disease
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Park JW, Park KU, Yoon YM, Jung YS, Song JH, Kim JQ
- KMID: 2082770
- Korean J Lab Med.
- 2002 Oct;22(5):312-318.
BACKGROUND: A preponderance of small low-density lipoproteins (LDL subclass phenotype B) has been closely associated with a high-risk for coronary artery disease. Lipoprotein lipase (LPL) gene polymorphisms have been found... -
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- A study on the association between pregnancy-induced hypertension and mutations for lipoprotein lipase gene
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Kim YJ, Park HS, Ha EH, Pang HG
- KMID: 2076255
- Korean J Obstet Gynecol.
- 2001 May;44(5):891-897.
OBJECTIVE: In the pathogenesis of pre-eclampsia, endothelial cell activation or dysfunction is the central theme and marked dyslipidemia may contribute to endothelial cell dysfunction. The objective of this study was... -
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- Effect of lipoprotein lipase gene polymorphism on lipid profile and body mass index in healthy Korean adult
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Park JS, Sung JD, Chae IH, Kim HS, Ju JR, Son DW, Oh BH, Lee MM, Park YB, Choi YS, Lee YW
- KMID: 2251335
- Korean J Med.
- 2000 Jan;58(1):57-66.
BACKGROUND: Lipoprotein lipase(LPL) plays a pivotal role in triglyceride-rich lipoprotein metabolism. It removes TG-rich lipoprotein from circulation by hydrolysing TG and produces active form of HDL. It also affects the development and... -
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- Polymorphisms at the Lipoprotein Lipase Gene: Possible Associations with Coronary Artery Disease and Blood Lipid Levels in Koreans
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Chung HJ, Yoon YM, Han TH, Park H, Song J, Kim JQ
- KMID: 2225892
- Korean J Clin Pathol.
- 1999 Dec;19(6):617-623.
BACKGROUND: Lipoprotein lipase (LPL) gene polymorphisms have been found associated with coronary artery disease (CAD) and lipid levels, but their impact is less clearly established. The analysis of associations of... -
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- Association of Lipoprotein Lipase Gene Polymorphism and Coronary Artery Disease in Korean
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Park J, Chae I, Kim H, Ju J, Sohn D, Oh B, Lee M, Park Y, Choi Y, Lee Y
- KMID: 2434652
- Korean Circ J.
- 1999 Jul;29(7):663-672.
BACKGROUND: The accumulation of lipoprotein and monocyte in the intima of the arterial wall is the most important step of the development of coronary artery disease (CAD). Lipoprotein lipase (LPL)... -
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- Change of plasma lipoproteins by heparin-released lipoprotein lipase
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Yang JY, Kim TK, Koo BS, Park BH, Park JW
- KMID: 1029932
- Exp Mol Med.
- 1999 Jun;31(2):60-64.
Lipoprotein lipase (LPL) is known to be attached to the luminal surface of vascular endothelial cells in a complex with membrane-bound heparan sulfate, and released into blood stream by heparin. LPL that... -
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- Association of Lipoprotein Lipase Gene Polymorphisms with Plasma Lipids in Ischemic Stroke Patients
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Kim JM, Kim J, Song HJ
- KMID: 1812888
- J Korean Neurol Assoc.
- 1999 May;17(3):340-346.
BACKGROUND: Lipoprotein lipase (LPL) is a key enzyme in the processing of triglycerides and plays a central role in lipid metabolism. It has been reported that the polymorphisms in the... -
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- Incidence of Lipoprotein Lipase Gene Polymorphism and Correlation with Severity of Coronary Artery Disease in Korean
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Chung JY, Kim JH, Lee MS, Sung BY, Kim YC, Kim JK, Ryu JK, Sung IH, Kwon GC, Jeon ES
- KMID: 1858324
- Korean Circ J.
- 1999 Jan;29(1):6-13.
- doi: 10.4070/kcj.1999.29.1.6
BACKGROUND: Lipoprotein lipase(LPL) is a key enzyme in the metabolism of serum triglyceride(TG) which is utilized in the peripheral tissue as free fatty acid and stored in adipose tissue. LPL... -
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