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MicroRNA-138 Suppresses Adipogenic Differentiation in Human Adipose Tissue-Derived Mesenchymal Stem Cells by Targeting Lipoprotein Lipase

Wang Y, Lin L, Huang Y, Sun J, Wang X, Wang P

PURPOSE: Adipogenic differentiation of adipose tissue-derived mesenchymal stem cells (AMSCs) is critical to many disease-related disorders, such as obesity and diabetes. Studies have demonstrated that miRNA-138 (miR-138) is closely involved...
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Blood Sugar Control and Low-Carbohydrate High-Fat Diet

Kang EH

Diabetes patients and pre-diabetic patients are increasing worldwide. Type 2 diabetes starts with insulin resistance, and the long-term habit of stimulating insulin secretions causes insulin resistance and accumulates body fat...
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LPL gene Pvu II polymorphism and hypertriglyceridemia: a meta-analysis involving 1,640 subjects

Li YY, Zhou YH, Gong G, Geng HY, Yang XX, Wang XM, Zhou CW, Xu J, Qian Y

BACKGROUND/AIMS: Although lipoprotein lipase (LPL) gene Pvu II polymorphism has been associated with an increased risk of hypertriglyceridemia (HT), there is no clear consensus within the scientific community. METHODS: A meta-analysis...
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Expression Levels of GABA-A Receptor Subunit Alpha 3, Gabra3 and Lipoprotein Lipase, Lpl Are Associated with the Susceptibility to Acetaminophen-Induced Hepatotoxicity

Kim M, Yun JW, Shin K, Cho Y, Yang M, Nam KT, Lim KM

Drug-induced liver injury (DILI) is the serious and fatal drug-associated adverse effect, but its incidence is very low and individual variation in severity is substantial. Acetaminophen (APAP)-induced liver injury accounts...
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A study of the lipoprotein lipase inhibitory mechanism of Poncirus trifoliata water extracts

Lee SM, Kang YH, Kim KK, Kim TW, Choe M

PURPOSE: Poncirus trifoliata has been reported to have anti-inflammatory, antioxidant, and immune activities. However, its anti-obesity activity and the mechanism by which the water extract of dried, immature fruit of...
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Gestational hyperlipidemia and acute pancreatitis with underlying partial lipoprotein lipase deficiency and apolipoprotein E3/E2 genotype

Han DH, Moh IH, Kim DM, Ihm SH, Choi MG, Yoo HJ, Hong EG

We report the case of a patient who experienced extreme recurrent gestational hyperlipidemia. She was diagnosed with partial lipoprotein lipase (LPL) deficiency but without an associated LPL gene mutation in...
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Inhibitory effects of Capsicum annuum L. water extracts on lipoprotein lipase activity in 3T3-L1 cells

Baek J, Lee J, Kim K, Kim T, Kim D, Kim C, Tsutomu K, Ochir S, Lee K, Park CH, Lee YJ, Choe M

  • KMID: 2391960
  • Nutr Res Pract.
  • 2013 Apr;7(2):96-102.
Obesity, an intractable metabolic disease, currently has no medical treatment without side effects, so studies have been actively carried out to find natural compounds that have anti-obesity activity with minimum...
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Interaction Effects of Lipoprotein Lipase Polymorphisms with Lifestyle on Lipid Levels in a Korean Population: A Cross-sectional Study

Pyun JA, Kim S, Park K, Baik I, Cho NH, Koh I, Lee JY, Cho YS, Kim YJ, Go MJ, Shim E, Kwack K, Shin C

Lipoprotein lipase (LPL) plays an essential role in the regulation of high-density lipoprotein cholesterol (HDLC) and triglyceride levels, which have been closely associated with cardiovascular diseases. Genetic studies in European...
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A Case of Lipoprotein Lipase Deficiency inan Infant with Recurrent Pancreatitis

Park HJ, Choi BS, Yang HR, Chang JY, Ko JS, Shin CH, Yang SW, Seo JK

  • KMID: 2037379
  • Korean J Pediatr Gastroenterol Nutr.
  • 2009 Mar;12(1):79-83.
Familial chylomicronemia syndrome is a rare disorder characterized by severe hypertriglyceridemia and fasting chylomicronemia. Causes of the syndrome include lipoprotein lipase (LPL) deficiency, apolipoprotein C-II deficiency, or the presence of...
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Association of lipoprotein lipase (LPL) single nucleotide polymorphisms with type 2 diabetes mellitus

Cho YS, Go MJ, Han HR, Cha SH, Kim HT, Min H, Shin HD, Park C, Han BG, Cho NH, Shin C, Kimm K, Oh B

The etiology and pathogenesis of type 2 diabetes mellitus (T2DM) are not completely understood although it is often associated with other conditions such as obesity, hypertension, and dyslipidemia. Lipoprotein lipase...
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Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte

Choi BH, Ahn IS, Kim YH, Park JW, Lee SY, Hyun CK, Do MS

  • KMID: 1115937
  • Exp Mol Med.
  • 2006 Dec;38(6):599-605.
Berberine (BBR), an isoquinoline alkaloid, has a wide range of pharmacological effects, yet its exact mechanism is unknown. In order to understand the anti-adipogenic effect of BBR, we studied the...
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Association between Low-Density Lipoprotein Subclasses and Lipoprotein Lipase Gene Polymorphisms in Coronary Artery Disease

Park JW, Park KU, Yoon YM, Jung YS, Song JH, Kim JQ

  • KMID: 2082770
  • Korean J Lab Med.
  • 2002 Oct;22(5):312-318.
BACKGROUND: A preponderance of small low-density lipoproteins (LDL subclass phenotype B) has been closely associated with a high-risk for coronary artery disease. Lipoprotein lipase (LPL) gene polymorphisms have been found...
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A study on the association between pregnancy-induced hypertension and mutations for lipoprotein lipase gene

Kim YJ, Park HS, Ha EH, Pang HG

  • KMID: 2076255
  • Korean J Obstet Gynecol.
  • 2001 May;44(5):891-897.
OBJECTIVE: In the pathogenesis of pre-eclampsia, endothelial cell activation or dysfunction is the central theme and marked dyslipidemia may contribute to endothelial cell dysfunction. The objective of this study was...
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Effect of lipoprotein lipase gene polymorphism on lipid profile and body mass index in healthy Korean adult

Park JS, Sung JD, Chae IH, Kim HS, Ju JR, Son DW, Oh BH, Lee MM, Park YB, Choi YS, Lee YW

  • KMID: 2251335
  • Korean J Med.
  • 2000 Jan;58(1):57-66.
BACKGROUND: Lipoprotein lipase(LPL) plays a pivotal role in triglyceride-rich lipoprotein metabolism. It removes TG-rich lipoprotein from circulation by hydrolysing TG and produces active form of HDL. It also affects the development and...
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Polymorphisms at the Lipoprotein Lipase Gene: Possible Associations with Coronary Artery Disease and Blood Lipid Levels in Koreans

Chung HJ, Yoon YM, Han TH, Park H, Song J, Kim JQ

  • KMID: 2225892
  • Korean J Clin Pathol.
  • 1999 Dec;19(6):617-623.
BACKGROUND: Lipoprotein lipase (LPL) gene polymorphisms have been found associated with coronary artery disease (CAD) and lipid levels, but their impact is less clearly established. The analysis of associations of...
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Association of Lipoprotein Lipase Gene Polymorphism and Coronary Artery Disease in Korean

Park J, Chae I, Kim H, Ju J, Sohn D, Oh B, Lee M, Park Y, Choi Y, Lee Y

  • KMID: 2434652
  • Korean Circ J.
  • 1999 Jul;29(7):663-672.
BACKGROUND: The accumulation of lipoprotein and monocyte in the intima of the arterial wall is the most important step of the development of coronary artery disease (CAD). Lipoprotein lipase (LPL)...
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Change of plasma lipoproteins by heparin-released lipoprotein lipase

Yang JY, Kim TK, Koo BS, Park BH, Park JW

  • KMID: 1029932
  • Exp Mol Med.
  • 1999 Jun;31(2):60-64.
Lipoprotein lipase (LPL) is known to be attached to the luminal surface of vascular endothelial cells in a complex with membrane-bound heparan sulfate, and released into blood stream by heparin. LPL that...
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Association of Lipoprotein Lipase Gene Polymorphisms with Plasma Lipids in Ischemic Stroke Patients

Kim JM, Kim J, Song HJ

  • KMID: 1812888
  • J Korean Neurol Assoc.
  • 1999 May;17(3):340-346.
BACKGROUND: Lipoprotein lipase (LPL) is a key enzyme in the processing of triglycerides and plays a central role in lipid metabolism. It has been reported that the polymorphisms in the...
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Incidence of Lipoprotein Lipase Gene Polymorphism and Correlation with Severity of Coronary Artery Disease in Korean

Chung JY, Kim JH, Lee MS, Sung BY, Kim YC, Kim JK, Ryu JK, Sung IH, Kwon GC, Jeon ES

BACKGROUND: Lipoprotein lipase(LPL) is a key enzyme in the metabolism of serum triglyceride(TG) which is utilized in the peripheral tissue as free fatty acid and stored in adipose tissue. LPL...
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