Korean J Clin Pathol.  1999 Dec;19(6):617-623.

Polymorphisms at the Lipoprotein Lipase Gene: Possible Associations with Coronary Artery Disease and Blood Lipid Levels in Koreans

• Chung HJ
• Yoon YM
• Han TH
• Park H
• Song J
• Kim JQ

Abstract

BACKGROUND
Lipoprotein lipase (LPL) gene polymorphisms have been found associated with coronary artery disease (CAD) and lipid levels, but their impact is less clearly established. The analysis of associations of LPL gene polymorphisms with CAD and lipid levels in Koreans was investigated.
METHODS
Analysis of PvuII (intron 6), HindIII (intron 8), and Ser447-Ter (exon 9) polymorphisms of LPL gene were performed using restriction enzyme digestion of amplified DNA products and lipid levels were analyzed in healthy control subjects (n=228) and patients with CAD (n=166).
RESULTS
PvuII, HindIII, and Ser447-Ter sites were in strong linkage disequilibrium. No statistical differences in the genotypic frequencies of PvuII, HindIII, and Ser447-Ter polymorphisms were observed between control and CAD groups. P2P2 genotype had higher triglyceride level in CAD group and lower HDL-cholesterol level in control group than the other genotypes (P1P1, P1P2). H2H2 genotype had higher triglyceride level in CAD group and lower HDL-cholesterol level in control group than the other genotypes (H1H1, H1H2).
CONCLUSIONS
Genotypes of LPL PvuII, HindIII, and Ser447-Ter polymorphisms were not associated with CAD. Individuals with P2P2 and H2H2 genotypes, however, had higher triglyceride and lower HDL-cholesterol levels that is known to be the most commmon dyslipidaemia in CAD patients.

Keyword

Lipoprotein lipase (LPL) gene polymorphism; Coronary artery disease (CAD); Lipid level

MeSH Terms

Coronary Artery Disease*
Coronary Vessels*
Digestion
DNA
Genotype
Humans
Linkage Disequilibrium
Lipoprotein Lipase*
Lipoproteins*
Triglycerides
DNA
Lipoprotein Lipase
Lipoproteins