- An Alternative Way of Constructing Ancestral Graphs Using Marker Allele Ages from Population Linkage Disequilibrium Information
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Park L
- KMID: 2166435
- Genomics Inform.
- 2009 Mar;7(1):1-12.
An alternative way of constructing ancestral graphs, which is different from the coalescent-based approach, is proposed using population linkage disequilibrium (LD) data. The main difference from the existing method is... -
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- Linkage Disequilibrium Analysis of Quantitative Trait Locus Associated with Lipid Profiles
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Song K, Lim KS, Cho JN, Jang YS, Park HY
- KMID: 2029031
- Korean Circ J.
- 2006 Oct;36(10):688-694.
- doi: 10.4070/kcj.2006.36.10.688
BACKGROUND AND OBJECTIVES : The common methods of genetic association analysis are sensitive to population stratification, which may easily lead to a spurious association result. We used a regression approach... -
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- Heterozygosities of 735 microsatellite markers and background linkage disequilibrium in the Korean population
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Lee KA, Kim JW
- KMID: 1115944
- Exp Mol Med.
- 2006 Dec;38(6):662-667.
Suitability of a specific population for linkage disequilibrium mapping studies of complex traits may be assessed by investigating the background linkage disequilibrium (BLD). We are unaware of studies for quantifying... -
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- Controlling Linkage Disequilibrium in Association Tests: Revisiting APOE Association in Alzheimer's Disease
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Park L
- KMID: 2166257
- Genomics Inform.
- 2007 Jun;5(2):61-67.
The allele frequencies of markers as well as linkage disequilibrium (LD) can be changed in cases due to the LD between markers and the disease allele, exhibiting spurious associations of... -
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- Power Analysis of Association Study Using Single Nucleotide Polymorphism
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Jeong SH, Kim YS
- KMID: 2340653
- J Korean Neuropsychiatr Assoc.
- 2002 Mar;41(2):201-214.
In order to find the disease susceptibility gene in these complex genetic trait, there have been much interests in association study using single nucleotide polymorphism (SNP). Association study can be... -
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- Genetic Studies of Psychiatric Disorders: The Basic Concepts and Methods of Quantitative Genetics
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Joo EJ, Kim YS
- KMID: 2340432
- J Korean Neuropsychiatr Assoc.
- 2000 Mar;39(2):257-272.
Quantitative medical genetics including genetic epidemiological studies, linkage studies, and association studies are the basis for molecular genetic studies to find the susceptible genes or responsible mutations for psychiatric disorders.... -
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- HapAnalyzer: Minimum Haplotype Analysis System for Association Studies
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Jung HY, Park JS, Park YJ, Kim YJ, Kimm K, Koh IS
- KMID: 2166173
- Genomics Inform.
- 2004 Jun;2(2):107-109.
SUMMARY: HapAnalyzer is an analysis system that provides minimum analysis methods for the SNP-based association studies. It consists of Hardy-Weinberg equilibrium (HWE) test, linkage disequilibrium (LD) computation, haplotype reconstruction,... -
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- Genetic Studies of Rheumatoid Arthritis: Progress and Challenges
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Kang C
- KMID: 2222838
- J Rheum Dis.
- 2015 Oct;22(5):274-281.
- doi: 10.4078/jrd.2015.22.5.274
Rheumatoid arthritis (RA) is a systemic inflammatory disease associated with both genetic and environmental factors. The DRB1 gene at the human leukocyte antigen (HLA) locus of chromosome 6p21.3 was the... -
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- Distinct Linkage Disequilibrium (LD) Runs of Single Nucleotide Polymorphisms and Microsatellite Markers; Implications for Use of Mixed Marker Haplotypes in LD-based Mapping
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Lee KA, Sohn KM, Cho SH, Hwang H, Kim SW, Won HH, Kim HJ, Kim MJ, Cho SS, Park JH, Kim JW
- KMID: 1778348
- J Korean Med Sci.
- 2007 Jun;22(3):425-430.
- doi: 10.3346/jkms.2007.22.3.425
It has been suggested that the haplotypic relationship between microsatellite markers and single nucleotide polymorphisms (SNPs) is of considerable importance, as microsatellite markers can potentially be incorporated into haplotypes containing... -
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- Heritability and Familiality of Temperament and Character Dimensions in Korean Families with Schizophrenic Linkage Disequilibrium
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Lee BD, Park JM, Lee YM, Moon E, Jeong HJ, Chung YI, Yi YM
- KMID: 2170989
- Clin Psychopharmacol Neurosci.
- 2016 May;14(2):203-209.
- doi: 10.9758/cpn.2016.14.2.203
OBJECTIVE: Categorical syndromes such as schizophrenia may represent complexes of many continuous psychological structural phenotypes along several dimensions of personality development/degeneration. The present study investigated the heritability and familiality of... -
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- Demographic Trends in Korean Native Cattle Explained Using Bovine SNP50 Beadchip
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Sharma A, Lim D, Chai HH, Choi BH, Cho Y
- KMID: 2366441
- Genomics Inform.
- 2016 Dec;14(4):230-233.
- doi: 10.5808/GI.2016.14.4.230
Linkage disequilibrium (LD) is the non-random association between the loci and it could give us a preliminary insight into the genetic history of the population. In the present study LD... -
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- Distribution of HLA class I alleles and haplotypes in Korean
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Kim TG, Han H, Lim BU, Kim W, Kim SM
- KMID: 1421972
- J Korean Med Sci.
- 1993 Jun;8(3):180-186.
- doi: 10.3346/jkms.1993.8.3.180
The antigen (phenotype), gene (allele) and haplotype frequencies of HLA class I were analysed in 4,622 Koreans. With allele frequencies of over 0.05, the most frequent HLA-A,-B and -C antigens... -
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- Characterization of Single Nucleotide Polymorphisms in 55 Disease-Associated Genes in a Korean Population
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Lee SK, Kim HG, Kang JJ, Oh W, Oh B, Kwack KB
- KMID: 2166273
- Genomics Inform.
- 2007 Dec;5(4):152-160.
Most common diseases are caused by multiple genetic and environmental factors. Among the genetic factors, single nucleotide polymorphisms (SNPs) are common DNA sequence variations in individuals and can serve as... -
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- Haplotype Phylogeny of a 200kb Region in the Human Chromosome X Terminal Band (q28)
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Kim S
- KMID: 2166409
- Genomics Inform.
- 2008 Sep;6(3):130-135.
The haplotypes of a 200 kb region in the human chromosome X terminal band (q28) were analyzed using the International HapMap Project PhaseII data, which had been collected for three... -
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- Effective Population Size of Korean Populations
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Park L
- KMID: 2391498
- Genomics Inform.
- 2014 Dec;12(4):208-215.
- doi: 10.5808/GI.2014.12.4.208
Recently, new methods have been developed for estimating the current and recent changes in effective population sizes. Based on the methods, the effective population sizes of Korean populations were estimated... -
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- Effects of Single Nucleotide Polymorphism Marker Density on Haplotype Block Partition
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Kim SA, Yoo YJ
- KMID: 2366436
- Genomics Inform.
- 2016 Dec;14(4):196-204.
- doi: 10.5808/GI.2016.14.4.196
Many researchers have found that one of the most important characteristics of the structure of linkage disequilibrium is that the human genome can be divided into non-overlapping block partitions in... -
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- Polymorphisms Linked to Factor IX Gene in Korean Population
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Shin JS, Jung SR, Son IP, Jo YH
- KMID: 2262127
- Korean J Obstet Gynecol.
- 2000 Nov;43(11):2038-2044.
OBJECTIVE: Linkage analysis is a very useful method for prenatal diagnosis of Hemophilia B, especially when a mutation was not identified. Seven polymorphic markers were studied in Korean populations to... -
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- Polymorphism of Antigen Processing ( TAP, HLA-DM, LMP ) Genes in Korean Population
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Kim TG, Han H, Choi HB
- KMID: 1928284
- Korean J Immunol.
- 1998 Sep;20(3):325-331.
Antigen processing (TAP, HLA-DM and LMP) genes map within the major histocompatibility complex (MHC) class II region between the HLA-DQB1 and -DPB1 loci, and are involved in the processing of... -
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- Effects of Intronic and Exonic Polymorphisms of Paraoxonase 1 (PON1) Gene on Serum PON1 Activity in a Korean Population
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Eom SY, Kim YS, Lee CJ, Lee CH, Kim YD, Kim H
- KMID: 1785955
- J Korean Med Sci.
- 2011 Jun;26(6):720-725.
- doi: 10.3346/jkms.2011.26.6.720
Paraoxonase 1 (PON1) hydrolyzes a number of toxic organophosphorous compounds and reduces lipid peroxide accumulation, and PON1 genetic polymorphisms in the coding region modulate serum PON1 activity. In this study,... -
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- The Distribution of HLA Antigens and Haplotypes in Koreans
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Kim HS, Hwang YS, Park MH
- KMID: 2146212
- Korean J Clin Pathol.
- 1997 Dec;17(6):1109-1123.
BACKGROUND: The HLA system is known to be the most polymorphic genetic system in human and there are characteristic racial differences in the distribution of HLA antigens, alleles, and haplotypes.... -
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