Korean Circ J.  2002 Jan;32(1):25-30. 10.4070/kcj.2002.32.1.25.

The Relationship of the C-514T Polymorphism of the Human Hepatic Lipase Gene Promoter with Plasma HDL-C Concentrations in Koreans

• Park KW
• Chae IH
• Choi JH
• Ju JR
• Oh S
• Kim CH
• Sohn DW
• Oh BH
• Lee MM
• Park YB
• Choi YS

• KMID: 1643991
• DOI: http://doi.org/10.4070/kcj.2002.32.1.25

Abstract

BACKGROUND AND OBJECTIVES
Hepatic lipase is a key enzyme in high density lipoprotein-cholesterol (HDL-C) metabolism and may therefore influence the susceptibility to coronary artery disease (CAD). Furthermore, there seems to be genetic variation in the - 514T allele frequency among different races.
SUBJECTS AND METHODS
To assess the - 514T allele frequency in Koreans, 99 subjects (54 patients with coronary artery disease & 45 normal controls) were examined by polymerase chain reaction (PCR) and restriction enzyme digestion. The lipid profiles of the subjects were also obtained.
RESULTS
The - 514T allele frequency was 0.33 in the CAD group and 0.41 in the normal controls, results which are higher than the equivalent reported for Caucasians. The plasma lipid profiles did not differ significantly between genotypes.
CONCLUSION
These data indicate that the Koreans in this study have a higher - 514T allele frequency than that reported for Caucasians. This elevation may be partly responsible for the higher HDL-C level in Koreans, although such polymorphism does not seem to significantly influence plasma HDL-C levels or CAD susceptibility.

Keyword

Lipase; Polymorphism; Lipoproteins; Coronary disease

MeSH Terms

Continental Population Groups
Coronary Artery Disease
Coronary Disease
Digestion
Gene Frequency
Genetic Variation
Genotype
Humans*
Lipase*
Lipoproteins
Metabolism
Plasma*
Polymerase Chain Reaction
Lipase
Lipoproteins