Korean J Intern Med.  2017 Nov;32(6):1018-1024. 10.3904/kjim.2016.043.

LPL gene Pvu II polymorphism and hypertriglyceridemia: a meta-analysis involving 1,640 subjects

• Li YY
• Zhou YH
• Gong G
• Geng HY
• Yang XX
• Wang XM
• Zhou CW
• Xu J
• Qian Y

• KMID: 2396761
• DOI: http://doi.org/10.3904/kjim.2016.043

Abstract

BACKGROUND/AIMS
Although lipoprotein lipase (LPL) gene Pvu II polymorphism has been associated with an increased risk of hypertriglyceridemia (HT), there is no clear consensus within the scientific community.
METHODS
A meta-analysis of 1,640 subjects from six individual studies was conducted to better elucidate the potential relationship between the LPL gene Pvu II polymorphism and HT within the Chinese population. Pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were evaluated by using fixed effect models.
RESULTS
Our analysis indicated a significant association between LPL gene Pvu II polymorphism and HT within the Chinese population under allelic (OR, 1.550; 95% CI, 1.320 to 1.830; p = 1.158 × 10-7), recessive (OR, 0.540; 95% CI, 0.390 to 0.750; p = 0.0002), dominant (OR, 1.889; 95% CI, 1.501 to 2.377; p = 5.960 × 10-8), homozygous (OR, 2.167; 95% CI, 1.531 to 3.067; p = 1.242 × 10-5), heterozygous (OR, 1.810; 95% CI, 1.419 to 2.309; p = 1.842 × 10-6), and additive genetic models (OR, 1.553; 95% CI, 1.320 to 1.828; p = 1.158 × 10-7).
CONCLUSIONS
Because LPL gene Pvu II restriction fragment length polymorphism polymorphism was associated with an elevated risk of HT, the P+ allele carriers of the LPL gene might be predisposed to HT.

Keyword

Lipoprotein lipase; Pvu II; Polymorphism; Hypertriglyceridemia

MeSH Terms

Alleles
Asian Continental Ancestry Group
Consensus
Humans
Hypertriglyceridemia*
Lipoprotein Lipase
Models, Genetic
Odds Ratio
Polymorphism, Restriction Fragment Length
Lipoprotein Lipase