J Korean Neurosurg Soc.  2011 Nov;50(5):415-419. 10.3340/jkns.2011.50.5.415.

Association of Estrogen Receptor Gene Polymorphism in Patients with Degenerative Lumbar Spondylolisthesise

Affiliations
  • 1Department of Orthopaedic Surgery, Medical Research Institute, Pusan National University School of Medicine, Busan, Korea. jungsublee@pusan.ac.kr
  • 2Department of Orthopaedic Surgery, Medical Research Institute, Pusan National University Yangsan Hospital, Yangsan, Korea.

Abstract


OBJECTIVE
The purpose of this study was to investigate the possible association of estrogen receptor alpha (ERalpha) gene polymorphisms in a cohort of degenerative spondylolisthesis (DS) patients.
METHODS
Accordingly, the authors examined the association between DS and ERalpha gene polymorphisms in 174 patients diagnosed with DS. The Pvu II and Xba I polymorphisms, bone mineral density at the lumbar spine and femoral neck, and biochemical markers were analyzed and compared in the 174 patients with DS and 214 patients with spinal stenosis (SS).
RESULTS
A comparison of genotype frequencies in DS and SS patients revealed a significant difference for the Pvu II polymorphism only (p=0.0452). No significant difference was found between these two groups with respect to the Xba I polymorphism, BMD or biochemical markers. No significant association was found between the Pvu II polymorphism of ERalpha and BMD, vertebral slip or biochemical markers in patients with DS.
CONCLUSION
These results suggest that the ERalpha gene polymorphism using Pvu II restriction enzyme influences the prevalence of DS.

Keyword

Degenerative spondylolisthesis; Estrogen receptor alpha; Polymorphism

MeSH Terms

Biomarkers
Bone Density
Cohort Studies
Estrogen Receptor alpha
Estrogens
Femur Neck
Genotype
Humans
Prevalence
Spinal Stenosis
Spine
Spondylolisthesis
Estrogen Receptor alpha
Estrogens
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