Korean J Obstet Gynecol.  2001 Sep;44(9):1627-1632.

A relationship between polymorphism of estrogen receptor gene and bone mineral density in premenopausal Korean women

• Hur SE
• Lyoo HS
• Park HM
• Yoon EH
• Shim SS
• Lee HS
• Kim HR
• Chung HW

Abstract

OBJECTIVE
The goal of this study was to determine the relationship between peak bone density and polymorphism of estrogen receptor gene in Korean premenopausal women. METHOD: We amplified Estrogen receptor by polymerase chain reaction and its digestion pattern of Pvu II and Xba I was examined from the 172 women who were in premenopause. The genetic subtype was classified by its digestion pattern and its combination genotype, e.g. PP, Pp, pp, XX, Xx, xx, PPXX, PPXx, PPxx, PpXx, Ppxx, xxpp. Bone mineral density of each genetic subtype were compared.
RESULTS
The genotype distribution was as follows: PP; 16.3%, Pp; 45.9%, pp; 37.8%, XX; 1.2%, Xx; 25.0%, xx; 73.8%, PPXX; 1.1%, PPXx; 8.7%, PPxx; 6.4%, PpXx; 16.3%, Ppxx; 29.7%, ppxx; 37.8%. ER gene polymorphism was associated with bone mineral density at forearm bone mineral density (P<0.05) with the xx genotype having the less BMD than Xx genotype.
CONCLUSION
Xba I estrogen receptor gene polymorphism is associated with bone mineral density in premenopausal women. Estrogen receptor gene polymorphism may have a modulatory role in bone metabolism in premenopausal women. And it can be used as predictor of forearm peak bone density.

Keyword

Estrogen receptor; polymorphism; peak bone mineral density

MeSH Terms

Bone Density*
Digestion
Estrogens*
Female
Forearm
Genotype
Humans
Metabolism
Polymerase Chain Reaction
Premenopause
Estrogens