Chonnam Med J.
2004 Mar;40(1):20-28.
A Study on the Restriction Fragment Length Polymorphisms of the Estrogen Receptor Gene and Quantitative Ultrasound Parameters in Bone of Premenopausal Korean Women
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- 1Department of Internal Medicine, Chonnam National University Medical School and Chonnam National University Research Institute of Medical Sciences, Gwangju, Korea. mychung@chonnam.ac.kr
Abstract
- Although genetic factors have been shown to contribute to bone mineral density (BMD), the relationship between estrogen receptor gene polymorphisms and BMD is controversial. We investigated the correlation between estrogen receptor-restriction fragment length polymorphisms (ER-RFLP) and quantitative ultrasound parameters of bone. The ER gene polymorphism was studied in 200 premenopausal women by PCR-RFLP. Bone mineral densities (BMD) were measured at the calcaneus by the quantitative ultrasound (QUS), which parameters were broadband ultrasound attenuation (BUA), speed of sound (SOS) and stiffness index. BUA values in Pvu II genotypes, that is, pp homozygotes, Pp heterozygotes, and PP homozygotes, were 111.8+/-11.0 dB/MHz, 108.8+/-12.6 dB/MHz, and 108.4+/-9.9 dB/MHz, respectively (p=0.206). SOS values in Pvu II genotypes were 1549.7+/-24.3 m/sec, 1548.1+/-25.4 m/sec, and 1548.2+/-26.4 m/sec (p=0.919). Stiffness index values in Pvu II genotypes showed 88.3+/-12.3, 85.9+/-13.0, and 85.9+/-11.7 (p=0.428). Also, each values in the Xba I genotypes showed similar results. There was no statistically significant relationship between ER-RFLP and quantitative ultrasound parameters. This study suggests that RFLP genotypes of estrogen receptor gene do not have any significant influence on QUS parameters of calcaneus in Korean premenopausal women. But more prospective study seems to be needed to investigate the correlation between bone mineral density and estrogen receptor gene polymorphism in Korean women.
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