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Efficacy of the Ketogenic Diet for Pediatric Epilepsy According to the Presence of Detectable Somatic mTOR Pathway Mutations in the Brain

Ko A, Sim NS, Choi HS, Yang D, Kim SH, Lee JS, Kim DS, Lee JH, Kim HD, Kang HC

Background and Purpose A multifactorial antiepileptic mechanism underlies the ketogenic diet (KD), and one of the proposed mechanisms of action is that the KD inhibits the mammalian target of rapamycin...
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F-box Protein βTrCP1 Is a Substrate of Extracellular Signal-regulated Kinase 2

Lee CJ, Lee GE, An HJ, Cho ES, Chen W, Lee JY, Kang HC, Lee HS, Cho YY

F-box proteins, consisting of 69 members which are organized into the three subclasses FBXW, FBXL, and FBXO, are the substrate specific recognition subunits of the SKP1-Cullin 1-F-box protein E3 ligase...
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Real-World Efficacy and Safety of Dulaglutide in Korean Patients with Type 2 Diabetes Mellitus: A Retrospective Study in a Tertiary Referral Center

Yoon JH, Hong AR, Choi W, Park JY, Kim HK, Kang HC

This study was conducted to evaluate the efficacy and safety of once-weekly dulaglutide therapy as add-on to oral antidiabetic drugs (OADs) and basal insulin in Korean patients with type 2...
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Is acute kidney injury after laparoscopic adrenalectomy related to the progression of chronic kidney disease in patients with primary aldosteronism?

Yoon JH, Chung HS, Hong AR, Kim HK, Kang HC, Kim MS, Hwang EC, Jung SI, Park K, Kwon D

Purpose: This study was conducted to investigate the predictors of kidney outcome after laparoscopic adrenalectomy in patients with primary aldosteronism (PA). Materials and Methods: We retrospectively reviewed the medical records of...
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Treatment strategies targeting specific genetic etiologies in epilepsy

Kim HJ, Kang HC

Recent genetic advances allow for identification of the genetic etiologies of epilepsy within individual patients earlier and more frequently than ever. Specific targeted treatments have emerged from improvements in understanding...
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Programmed Cell Death-Ligand 1 (PD-L1) gene Single Nucleotide Polymorphism in Graves’ Disease and Hashimoto’s Thyroiditis in Korean Patients

Yoon JH, Shin Mh, Kim HN, Choi W, Park JY, Hong AR, Kim HK, Kang HC

Background: Programmed cell death-ligand 1 (PD-L1) has an important role in regulating immune reactions by binding to programmed death 1 (PD-1) on immune cells, which could prevent the exacerbation of...
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Spurious Thyroid Function Test Results due to Biotin Interference: a Report of Three Cases and a Literature Review

Park JY, Choi W, Yoon JH, Kang HC

Biotin (vitamin B7) is a water-soluble vitamin used as a co-enzyme for carboxylases essential for human metabolism. The high affinity to streptavidin makes biotin an important substance in immunoassays. Excessive...
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A Patient with Neutropenia and Splenomegaly: A Case Report from Department of Family Medicine in Tertiary Hospital Center

Cho J, Song Y, Lee J, Lee D, Go Y, Kang HC

Pancytopenia represents a unique challenge for primary care doctors and its etiological causes encompass various specialties, including hematology and rheumatology. Despite the existence of effective tests such as bone marrow...
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Characteristics of Immune-Related Thyroid Adverse Events in Patients Treated with PD-1/PD-L1 Inhibitors

Yoon JH, Hong AR, Kim HK, Kang HC

Background: Thyroid immune-related adverse events (IRAEs) have been reported in patients treated with programmed cell death protein-1 (PD-1) and programmed cell death protein-ligand 1 (PD-L1) inhibitors. We investigated the incidence...
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Clinical Features and Treatment Outcomes of Seronegative Pediatric Autoimmune Encephalitis

Lee S, Kim HD, Lee JS, Kang HC, Kim SH

Background and Purpose New diagnostic criteria for pediatric autoimmune encephalitis (AIE) have been introduced recently. A substantial proportion of cases of pediatric AIE are diagnosed as seronegative based on these...
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Protocol for a Korean Multicenter Prospective Cohort Study of Active Surveillance or Surgery (KoMPASS) in Papillary Thyroid Microcarcinoma

Jeon MJ, Kang YE, Moon JH, Lim DJ, Lee CY, Lee YS, Kim SW, Kim MH, Kim BH, Kang HC, Shong M, Cho SW, Kim WB

Background: A Korean Multicenter Prospective cohort study of Active Surveillance or Surgery (KoMPASS) for papillary thyroid microcarcinomas (PTMCs) has been initiated. The aim is to compare clinical outcomes between active...
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Principles and Conceptual Framework for the Introduction of Korean Sickness Benefit

Kang HC

Both access to healthcare services and income security in case of personal illness are being needed to achieve universal health coverage, which is enshrined in the human rights to health...
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Synthetic Computed Tomography Generation while Preserving Metallic Markers for Three-Dimensional Intracavitary Radiotherapy: Preliminary Study

Jin H, Kang S, Kang HC, Choi CH

Purpose: This study aimed to develop a deep learning architecture combining two task models to generate synthetic computed tomography (sCT) images from low-tesla magnetic resonance (MR) images to improve metallic...
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Screening of Tuberous Sclerosis-Associated Neuropsychiatric Disorders in Korea Using the TAND Checklist

Park S, Eom S, Kang HC, Lee JS, Kim HD, Chung HJ

Purpose: The present study aimed to elucidate the clinical characteristics of children with tuberous sclerosis complex (TSC) in Korea using the Tuberous Sclerosis-Associated Neuropsychiatric Disorders (TAND) checklist to evaluate the...
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Effects of Salbutamol in Collagen like Tail Subunit of Asymmetric Acetylcholinesterase-Related Congenital Myasthenic Syndrome: A First Korean Case

Kim HG, Lee JS, Kim KW, Kang HC, Kim SH

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Clinical Implication of World Health Organization Classification in Patients with Follicular Thyroid Carcinoma in South Korea: A Multicenter Cohort Study

Jin M, Kim ES, Kim BH, Kim HK, Yi HS, Jeon MJ, Kim TY, Kang HC, Kim WB, Shong YK, Kim M, Kim WG

Background: The study aimed to compare the prognostic value of the 4th edition of World Health Organization classification (WHO-2017) with the previous WHO classification (WHO-2004) for follicular thyroid carcinoma (FTC). Methods:...
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Vandetanib for the Management of Advanced Medullary Thyroid Cancer: A Real-World Multicenter Experience

Kim M, Yoon JH, Ahn J, Jeon MJ, Kim HK, Lim DJ, Kang HC, Kim IJ, Shong YK, Kim TY, Kim BH

Background: Vandetanib is the most widely used tyrosine kinase inhibitor for the treatment of patients with advanced medullary thyroid cancer (MTC). However, only limited data regarding its use outside clinical...
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The clinical meaning of pre- and post-ablation thyroglobulin levels at first radioiodine therapy in patients with papillary thyroid cancer

Kim HK, Yoon JH, Cho JS, Kwon SY, Yoo SW, Kang HC

Background/Aims: This study was conducted to identify prognostic factors in patients with papillary thyroid cancer (PTC) at the time of first radioactive iodine (RAI) therapy, and to evaluate the clinical...
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Repurposing Auranofin, an Anti-Rheumatic Gold Compound, to Treat Acne Vulgaris by Targeting the NLRP3 Inflammasome

Yang G, Lee SJ, Kang HC, Cho YY, Lee HS, Zouboulis CC, Han SH, Ma KH, Jang JK, Lee JY

Activation of the NLRP3 inflammasome is critical for host defense as well as the progression of inflammatory diseases through the production of the proinflammatory cytokine IL-1β, which is cleaved by...
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Efficacy and Safety of Lacosamide in Adolescents with Lennox-Gastaut Syndrome

Choi HS, Kim SH, Kang HC, Lee JS, Kim HD

Purpose: We aimed to assess the efficacy and safety of lacosamide in Korean adolescents with Lennox-Gastaut syndrome (LGS), especially in those who concomitantly used other sodium channel blockers (SCBs). Methods:...
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