Ewha Med J.  2003 Jun;26(2):91-96. 10.12771/emj.2003.26.2.91.

Association of the Estrogen Receptor-alpha Gene Polymorphism with the Risk of Endometriosis in Korean Women

• Lee SR
• Hur SE
• Moon HS
• Kim HL
• Chung HW

• KMID: 2352859
• DOI: http://doi.org/10.12771/emj.2003.26.2.91

Abstract

OBJECTIVE
To investigate whether polymorphism of gene encoding estrogen receptor-alpha is associated with the risk of endometriosis in Korean women. MATERIAL AND METHODS: We investigated 136 patients with histopathologically confirmed endometriosis rAFS stage III/IV and 251 control group women who were surgically proven to have no endometriosis. Polymerase chain reaction(PCR) and restriction fragment length polymorphism (RFLP) of PCR products were done to determine each participant's estrogen receptor-alpha genotype.
RESULTS
The distridution according to PvuII genetic polymorphism of estrogen receptor-alpha were as follows. PP, Pp and pp were 14.7%(20 women), 39.0%(53 women) and 46.3%(63 women) in the study group and 13.9%(35 women), 38.6%(98 women) and 47.4%(119 women) in the control group, respectively. There was no significant difference between the study group and the control group.
CONCLUSION
The results suggest that estrogen receptor-alpha genetic polymorphism may not be associated with the development of endometriosis in Korean women.

Keyword

Endometriosis; Genetic polymorphism; Estrogen receptor-alpha; PvuII

MeSH Terms

Endometriosis*
Estrogens*
Female
Genotype
Humans
Polymerase Chain Reaction
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Estrogens