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Testosterone and Dehydroepiandrosterone Treatment in Ageing Men: Are We All Set?

Walther A, Seuffert J

Although demographic statistics show that populations around the world are rapidly ageing, this rising life expectancy is accompanied by an increase in the number of people living with age-related chronic...
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Inhibition of Insulin-Like Growth Factor-1–Induced Sebum Production by Bilobetin in Cultured Human Sebocytes

Wang C, Hwang YL, Li XM, Kim SJ, Zhu MJ, Lee JH, Jiang RH, Kim CD

BACKGROUND: Sebocytes are the major cells of sebaceous gland. The essential role of sebocytes is the production of sebum, a specific lipid mixture, that covers the body surface and provides...
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Use of docetaxel plus androgen deprivation therapy for metastatic hormone-sensitive prostate cancer in Korean patients: A retrospective study

Kwon WA, Joung JY, Lee JE, Choi SY, Kim SH, Seo HK, Lee KH, Kim CS

PURPOSE: We aimed to evaluate the efficacy and safety of the use of docetaxel plus androgen deprivation therapy (ADT) for metastatic hormone-sensitive prostate cancer (mHSPC) in Korean patients. MATERIALS AND METHODS:...
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Dehydroepiandrosterone and Erectile Function: A Review

El-Sakka A

To review the contemporary knowledge regarding the dehydroepiandrosterone and erectile function. Medline was reviewed for English-language journal articles spanning the time between January 1990 and December 2017, using the terms...
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Shifting the Paradigm of Testosterone Replacement Therapy in Prostate Cancer

Bell MA, Campbell J, Joice G, Sopko NA, Burnett AL

Historically, testosterone and prostate cancer have been demonstrated to have a positive association leading providers to forgo testosterone replacement therapy (TRT) in men with concurrent histories of hypogonadism and prostate...
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Histomorphological changes in the common carotid artery of the male rat in induced hypogonadism

Cheruiyot , Olabu B, Kamau M, Ongeti K, Mandela P

The role of androgens in the development of cardiovascular diseases remains controversial. The current study therefore sought to determine the changes in the histomorphology of the common carotid artery of...
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The association between skeletal maturation and adrenal androgen levels in obese children and adolescents

Kim SE, Jang JW, Ahn MB, Kim SH, Cho WK, Cho KS, Park SH, Jung MH, Suh BK

PURPOSE: This study aimed to investigate the association between skeletal maturation and adrenal androgen levels in obese children and adolescents. METHODS: Fifty-three children and adolescents (aged 7–15 years) diagnosed as obese...
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Effects of Adrenal Androgen Levels on Bone Age Advancement in Prepubertal Children: Using the Ewha Birth and Growth Cohort Study

Kwon JH, Lee HA, Kim YJ, Lee H, Park EA, Cho SJ, Gwak HS, Ha E, Park H, Kim HS

Bone age (BA) advancement in prepubertal children may be associated with earlier onset of puberty and obesity. This study aimed to define the effects of adrenal androgen levels on the...
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Induction of Integrin Signaling by Steroid Sulfatase in Human Cervical Cancer Cells

Ye DJ, Kwon YJ, Shin S, Baek HS, Shin DW, Chun YJ

Steroid sulfatase (STS) is an enzyme responsible for the hydrolysis of aryl and alkyl sulfates. STS plays a pivotal role in the regulation of estrogens and androgens that promote the...
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Larger Testicular Volume Is Independently Associated with Favorable Indices of Lung Function

Kim TB, Park IN

BACKGROUND: Men with chronic obstructive pulmonary disease, have reduced endogenous testosterone levels, but the relationship between pulmonary function and endogenous testosterone levels, is inconsistent. Testicular volume is a known indicator...
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The role of sex steroid hormones in the pathophysiology and treatment of sarcopenia

Kim YJ, Tamadon A, Park HT, Kim H, Ku SY

Sex steroids influence the maintenance and growth of muscles. Decline in androgens, estrogens and progesterone by aging leads to the loss of muscular function and mass, sarcopenia. These steroid hormones...
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Etiology and therapeutic outcomes of children with gonadotropin-independent precocious puberty

Kang E, Cho JH, Choi JH, Yoo HW

PURPOSE: This study was performed to investigate the etiology, clinical features, and outcomes of patients with gonadotropin-independent precocious puberty (GIPP). METHODS: The study included 16 patients (14 female and 2 male...
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A Case of Acne Fulminans after Oral Isotretinoin Therapy

Ko HS, Moon JH, Kang MJ, Byun JW, Shin J, Choi GS

  • KMID: 2251151
  • Korean J Dermatol.
  • 2016 May;54(4):297-300.
Acne fulminans (AF) is a rare severe form of acne associated with systemic symptoms. It primarily affects male adolescents and is clinically characterized by painful ulcerative nodules on the face,...
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Pharmacologic management of female sexual dysfunction

Yoon H, Park K

In female sexual dysfunction (FSD), psychological and contextual factors significantly influence organic components of sexual response and behavior. The hormonal environment also affects FSD. Therefore, a tailored medical approach to...
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Pharmacologic Therapy for Cancer Anorexia-Cachexia Syndrome

Yoon S, Kim H

Cancer-related anorexia-cachexia syndrome (CACS) is a hypercatabolic state, characterized by reduced appetite and weight loss due to ongoing loss of skeletal muscle mass and adipose tissue. CACS occurs mainly in...
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A case of 17 alpha-hydroxylase deficiency

Kim SM, Rhee JH

17alpha-hydroxylase and 17,20-lyase are enzymes encoded by the CYP17A1 gene and are required for the synthesis of sex steroids and cortisol. In 17alpha-hydroxylase deficiency, there are low blood levels of...
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Elderly men over 65 years of age with late-onset hypogonadism benefit as much from testosterone treatment as do younger men

Saad F, Yassin A, Haider A, Doros G, Gooren L

PURPOSE: To investigate the potential benefits of testosterone administration to elderly men (>65 years) with late-onset hypogonadism (LOH) in comparison with younger men and to assess the safety of testosterone...
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Testosterone Replacement Therapy and Prostate Cancer Incidence

Eisenberg

While early studies demonstrated a positive association between testosterone and prostate cancer, evidence on the nature of the relationship has evolved with time and newer data. Studies examining links between...
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Empirical medical therapy in idiopathic male infertility: Promise or panacea?

Jung JH, Seo JT

Male factors account for 20%-50% of cases of infertility and in 25% of cases, the etiology of male infertility is unknown. Effective treatments are well-established for hypogonadotropic hypogonadism, male accessory...
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Pattern Alopecia during Hormonal Anticancer Therapy in Patients with Breast Cancer

Park J, Kim JI, Yun SK, Kim HU, Ihm CW

We report five cases of pattern alopecia in female patients who are undergoing hormonal anticancer therapy for the prevention of recurrence of breast cancer after surgery. Three patients demonstrated male...
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