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Multiple Roles of Sirtuin 6 in Adipose Tissue Inflammation

Bae EJ, Park BH

Adipose tissue (AT) inflammation is strongly associated with obesity-induced insulin resistance. When subjected to metabolic stress, adipocytes become inflamed and secrete a plethora of cytokines and chemokines, which recruit circulating...
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Cardiovascular Disease Risk in Children and Adolescents with Attention Deficit/Hyperactivity Disorder

Uzun N, Akıncı MA, Alp H

Objective: The aim of this case-controlled study is to evaluate chronic inflammation, subclinical atherosclerosis and cardiovascular disease risk in children and adolescents with ADHD. Methods: A total of 51 medication-free children...
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Perirenal Fat and Kidney Function Deterioration in Patients With Acute Decompensated Heart Failure

Cho IJ, Wi J, Lee SE, Kim DH, Pyun WB

Background and Objectives: The thick perirenal fat pad can induce high intracapsular pressure and cause compression of the renal vasculature and resultant congestive nephropathy. The current study investigated the association...
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Association of Myosteatosis with Nonalcoholic Fatty Liver Disease, Severity, and Liver Fibrosis Using Visual Muscular Quality Map in Computed Tomography

Kim HS, Lee J, Kim EH, Lee MJ, Bae IY, Lee WJ, Park JY, Kim HK, Jung CH

Background: The association of myosteatosis measured using visual muscular quality map in computed tomography (CT) with nonalcoholic fatty liver disease (NAFLD), its severity, and fibrosis was analyzed in a large...
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Efficacy and Safety of Cold-Induced Noninvasive Targeted Fat Reduction in Pseudogynecomastia

Hong JY, Park SJ, Kim SY, Kim BJ

Background: Treatment options for pseudogynecomastia are limited, and the demand for noninvasive breast fat reduction is increasing. Objective: We evaluated the efficacy and safety of a cold-induced lipolysis device for treating...
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L-Theanine-Treated Adipose-Derived Mesenchymal Stem Cells Alleviate the Cytotoxicity Induced by N-Nitrosodiethylamine in Liver

Lai YJ, Sung YT, Lai YA, Chen LN, Chen TS, Chien CT

BACKGROUND: Liver inflammation is the main cause of severe liver diseases, including liver fibrosis, steatohepatitis, cirrhosis and hepatocellular carcinoma. Cell therapy topics are receiving increasingly more attention. The therapeutic applications...
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Decellularized Human Adipose Tissue as an Alternative Graft Material for Bone Regeneration

Ahn WB, Lee YB, Ji YH, Moon KS, Jang HS, Kang SW

BACKGROUND: Tissue engineering approaches to treat damaged bone include various tissue transplants such as autologous, allogeneic, and xenografts. Artificial materials have been widely introduced to meet the demand for graft...
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Xenogeneic Humoral Immune Responses to Human Mesenchymal Stem Cells in Mice

Hong JM, Kim JH, Kim GH, Shin HM, Hwang Yi

Background and Objectives: Many preclinical studies have been conducted using animal disease models to determine the effectiveness of human mesenchymal stem cells (hMSCs) for treating immune and inflammatory diseases based...
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Sestrin2 Regulates Beneficial β3-Adrenergic Receptor-Mediated Effects Observed in Inguinal White Adipose Tissue and Soleus Muscle

Park MJ, Kim JW, Roh E, Choi KM, Baik SH, Hwang HJ, Yoo HJ

Sestrin2, a well-known adenosine monophosphate-activated protein kinase (AMPK) regulator, plays a protective role against metabolic stress. The β3-adrenergic receptor (β3AR) induces fat browning and inhibits muscle atrophy in an AMPK-dependent...
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Dietary supplementation with Korean pine nut oil decreases body fat accumulation and dysregulation of the appetite-suppressing pathway in the hypothalamus of high-fat diet-induced obese mice

Shin S, Park S, Lim Y, Han SN

BACKGROUND/OBJECTIVES: Korean pine nut oil (PNO) has been reported to suppress appetite by increasing satiety hormone release. However, previous studies have rendered inconsistent results and there is lack of information...
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Healthy versus Unhealthy Adipose Tissue Expansion: the Role of Exercise

Meister BM, Hong SG, Shin J, Rath M, Sayoc J, Park JY

Although the hallmark of obesity is the expansion of adipose tissue, not all adipose tissue expansion is the same. Expansion of healthy adipose tissue is accompanied by adequate capillary angiogenesis and...
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Acute Infrapatellar Fat Pad Injury after Non-contact, Hyperflexion Injury in a Professional Football Player: A Case Report

Lee CC, Park KB, Han JW

  • KMID: 2526689
  • Korean J Sports Med.
  • 2022 Mar;40(1):54-58.
We describe the case of a 28-year-old male professional football player experiencing right knee pain after noncontact, hyperflexion injury during a regular professional football league match. Infrapatellar fat pad injury...
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The Effect of Stromal Vascular Fraction on Scar Formation of Transverse Rectus Abdominis Muscle Flap Donor Sites: A Pilot Study

Koo HT, Jin US

Background: Stromal vascular fraction (SVF), which plays a substantial role in wound healing, has been discussed in many recent studies concerning its positive effect on scar formation. Our study explored...
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Impact of Skeletal Muscle Loss and Visceral Obesity Measured Using Serial CT on the Prognosis of Operable Breast Cancers in Asian Patients

Kwon Mr, Ko ES, Park MS, Jeong WK, Hwang NY, Kim JH, Lee JE, Kim SW, Yu JH, Han BK, Ko EY, Choi JS, Park KW

Objective: This study aimed to investigate the impact of baseline values and temporal changes in body composition parameters, including skeletal muscle index (SMI) and visceral adipose tissue area (VAT), measured...
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Obesity, Diabetes, and Increased Cancer Progression

Kim DS, Scherer PE

Rates of obesity and diabetes have increased significantly over the past decades and the prevalence is expected to continue to rise further in the coming years. Many observations suggest that...
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Brown Fat as a Regulator of Systemic Metabolism beyond Thermogenesis

Yuko OO, Saito M

Brown adipose tissue (BAT) is a specialized tissue for nonshivering thermogenesis to dissipate energy as heat. Although BAT research has long been limited mostly in small rodents, the rediscovery of...
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Ipragliflozin, an SGLT2 Inhibitor, Ameliorates High-Fat Diet-Induced Metabolic Changes by Upregulating Energy Expenditure through Activation of the AMPK/ SIRT1 Pathway

Lee JY, Lee M, Lee JY, Bae J, Shin E, Lee Yh, Lee BW, Kang ES, Cha BS

Background: Sodium-glucose co-transporter 2 (SGLT2) inhibitors are a new class of antidiabetic drugs that exhibit multiple extraglycemic effects. However, there are conflicting results regarding the effects of SGLT2 inhibition on...
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Association of waist circumference with muscle and fat mass in adults with a normal body mass index

Lee G, Choi S, Park SM

BACKGROUND/OBJECTIVES: We aimed to investigate the association of waist circumference (WC) with body composition among individuals with a normal body mass index (BMI) to distinguish muscle and fat mass, as...
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Specialized Proresolving Mediators for Therapeutic Interventions Targeting Metabolic and Inflammatory Disorders

Han YH, Lee K, Saha A, Han J, Choi H, Noh M, Lee YH, Lee MO

Uncontrolled inflammation is considered the pathophysiological basis of many prevalent metabolic disorders, such as nonalcoholic fatty liver disease, diabetes, obesity, and neurodegenerative diseases. The inflammatory response is a self-limiting process...
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Evaluation of body composition using computed tomography in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis

Ahn SS, Yoo BW, Kwon HC, Yoo J, Jung SM, Song JJ, Park YB, Lee SW

Background/Aims: Measures of body composition, including visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and skeletal muscle area (SMA), are considered important prognostic factors in chronic diseases. The association of...
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