- Protocatechuic Aldehyde Represses Proliferation and Migration of Breast Cancer Cells through Targeting C-terminal Binding Protein 1
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Deng Y, Guo W, Li G, Li S, Li H, Li X, Niu B, Song M, Zhang Y, Xu Z, Li F
- KMID: 2470879
- J Breast Cancer.
- 2020 Feb;23(1):20-35.
- doi: 10.4048/jbc.2020.23.e7
PURPOSE: C-terminal binding protein 1 (CtBP1) is a transcriptional co-repressor that is overexpressed in many cancers. CtBP1 transcriptionally represses a broad array of tumor suppressors, which promotes cancer cell proliferation,... -
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- MicroRNA-138 Suppresses Adipogenic Differentiation in Human Adipose Tissue-Derived Mesenchymal Stem Cells by Targeting Lipoprotein Lipase
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Wang Y, Lin L, Huang Y, Sun J, Wang X, Wang P
- KMID: 2463798
- Yonsei Med J.
- 2019 Dec;60(12):1187-1194.
- doi: 10.3349/ymj.2019.60.12.1187
PURPOSE: Adipogenic differentiation of adipose tissue-derived mesenchymal stem cells (AMSCs) is critical to many disease-related disorders, such as obesity and diabetes. Studies have demonstrated that miRNA-138 (miR-138) is closely involved... -
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- Methyl-CpG Binding Protein 2 in Alzheimer Dementia
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Kim B, Choi Y, Kim HS, Im HI
- KMID: 2467315
- Int Neurourol J.
- 2019 Nov;23(Suppl 2):S72-S81.
- doi: 10.5213/inj.1938196.098
Despite decades of research on Alzheimer disease, understanding the complexity of the genetic and molecular interactions involved in its pathogenesis remains far from our grasp. Methyl-CpG Binding Protein 2 (MeCP2)... -
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- Neutrophilic Granule Protein Is a Novel Murine LPS Antagonist
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Hong J, Qu P, Wuest TR, Huang H, Huang C, Lin PC
- KMID: 2461198
- Immune Netw.
- 2019 Oct;19(5):e34.
- doi: 10.4110/in.2019.19.e34
Neutrophilic granule protein (NGP) was previously reported as a granular protein of neutrophils in mouse, but the function has not been known clearly. We found the presence of the possible... -
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- Viperin Differentially Induces Interferon-Stimulated Genes in Distinct Cell Types
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Kim JJ, Kim KS, Eom J, Lee JB, Seo JY
- KMID: 2461197
- Immune Netw.
- 2019 Oct;19(5):e33.
- doi: 10.4110/in.2019.19.e33
Viperin is an IFN-stimulated gene (ISG)-encoded protein that was identified in human primary macrophages treated with IFN-γ and in human primary fibroblasts infected with cytomegalovirus (CMV). This protein plays multiple... -
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- Bile Acid Transporters Are Expressed and Heterogeneously Distributed in Rat Bile Ducts
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Luo ZL, Cheng L, Wang T, Tang LJ, Tian FZ, Xiang K, Cui L
- KMID: 2458514
- Gut Liver.
- 2019 Sep;13(5):569-575.
- doi: 10.5009/gnl18265
BACKGROUND/AIMS: Cholangiocytes are capable of reabsorbing bile salts from bile, but the pathophysiological significance of this process is unclear. To this end, we detected the expression and distribution of bile... -
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- Cytokine Production in Cholangiocarcinoma Cells in Response to Clonorchis sinensis Excretory-Secretory Products and Their Putative Protein Components
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Pak JH, Lee JY, Jeon BY, Dai F, Yoo WG, Hong SJ
- KMID: 2459475
- Korean J Parasitol.
- 2019 Aug;57(4):379-387.
- doi: 10.3347/kjp.2019.57.4.379
Clonorchis sinensis is a carcinogenic human liver fluke that promotes hepatic inflammatory environments via direct contact or through their excretory-secretory products (ESPs), subsequently leading to cholangitis, periductal fibrosis, liver cirrhosis,... -
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- p62 Negatively Regulates TLR4 Signaling via Functional Regulation of the TRAF6-ECSIT Complex
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Kim MJ, Min Y, Kwon J, Son J, Im JS, Shin J, Lee KY
- KMID: 2450201
- Immune Netw.
- 2019 Jun;19(3):e16.
- doi: 10.4110/in.2019.19.e16
Sequestosome 1 (SQSTM1, p62), a ubiquitin binding protein, plays a role in cell signaling, oxidative stress, and autophagy. However, its functional role in inflammatory signaling is controversial. Recent studies have... -
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- Inhibition of Insulin-Like Growth Factor-1–Induced Sebum Production by Bilobetin in Cultured Human Sebocytes
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Wang C, Hwang YL, Li XM, Kim SJ, Zhu MJ, Lee JH, Jiang RH, Kim CD
- KMID: 2444861
- Ann Dermatol.
- 2019 Jun;31(3):294-299.
- doi: 10.5021/ad.2019.31.3.294
BACKGROUND: Sebocytes are the major cells of sebaceous gland. The essential role of sebocytes is the production of sebum, a specific lipid mixture, that covers the body surface and provides... -
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- Endoplasmic Reticulum Stress Induces MUC5AC and MUC5B Expression in Human Nasal Airway Epithelial Cells
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Kim MH, Bae CH, Choi YS, Na HG, Song SY, Kim YD
- KMID: 2447427
- Clin Exp Otorhinolaryngol.
- 2019 May;12(2):181-189.
- doi: 10.21053/ceo.2018.00493
OBJECTIVES: Endoplasmic reticulum (ER) stress is known to be associated with inflammatory airway diseases, and three major transmembrane receptors: double-stranded RNA-activated protein kinase-like ER kinase, inositol requiring enzyme 1, and... -
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- Fumigaclavine C attenuates adipogenesis in 3T3-L1 adipocytes and ameliorates lipid accumulation in high-fat diet-induced obese mice
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Yu WG, He Y, Chen YF, Gao XY, Ning WE, Liu CY, Tang TF, Liu Q, Huang XC
- KMID: 2443604
- Korean J Physiol Pharmacol.
- 2019 May;23(3):161-169.
- doi: 10.4196/kjpp.2019.23.3.161
Fumigaclavine C (FC), an active indole alkaloid, is obtained from endophytic Aspergillus terreus (strain No. FC118) by the root of Rhizophora stylosa (Rhizophoraceae). This study is designed to evaluate whether... -
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- Anti-inflammatory effect of Lycium barbarum on polarized human intestinal epithelial cells
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Lee SR, Hwang HJ, Yoon JG, Bae EY, Goo KS, Cho SJ, Cho JA
- KMID: 2442366
- Nutr Res Pract.
- 2019 Apr;13(2):95-104.
- doi: 10.4162/nrp.2019.13.2.95
BACKGROUND/OBJECTIVES: Inflammatory Bowel Disease (IBD) has rapidly escalated in Asia (including Korea) due to increasing westernized diet patterns subsequent to industrialization. Factors associated with endoplasmic reticulum (ER) stress are demonstrated... -
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- Diagnostic Odyssey and Application of Targeted Exome Sequencing in the Investigation of Recurrent Infant Deaths in a Syrian Consanguineous Family: a Case of Spinal Muscular Atrophy with Respiratory Distress Type 1
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Kim YA, Jin HY, Kim YM
- KMID: 2441911
- J Korean Med Sci.
- 2019 Mar;34(9):e54.
- doi: 10.3346/jkms.2019.34.e54
Spinal muscular atrophy with respiratory distress type 1 (SMARD1) is a rare autosomal recessive disorder caused by a defect in the immunoglobulin mu binding protein 2 (IGHMBP2) gene, leading to... -
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- Treadmill Exercise Alleviates Circadian Rhythm Disruption-Induced Memory Deficits by Activation of Glucocorticoid Receptor and Brain-Derived Neurotrophic Factor-Dependent Pathway
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Kim SE, Ko IG, Ji ES, Jin JJ, Hwang L, Kim SH, Cho S, Kim CJ, Kim K, Kim KH
- KMID: 2448806
- Int Neurourol J.
- 2019 Feb;23(Suppl 1):S40-S49.
- doi: 10.5213/inj.1938048.024
PURPOSE: Circadian rhythm affects learning process, memory consolidation, and long-term memory. In this study, the alleviating effect of exercise on circadian rhythm disruption-induced memory deficits was investigated. METHODS: BMAL1 knockdown transgenic... -
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- Suppressor of Variegation 3–9 Homolog 2, a Novel Binding Protein of Translationally Controlled Tumor Protein, Regulates Cancer Cell Proliferation
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Kim AR, Sung JY, Rho SB, Kim YN, Yoon K
- KMID: 2442016
- Biomol Ther.
- 2019 Feb;27(2):231-239.
- doi: 10.4062/biomolther.2019.021
Suppressor of Variegation 3–9 Homolog 2 (SUV39H2) methylates the lysine 9 residue of histone H3 and induces heterochromatin formation, resulting in transcriptional repression or silencing of target genes. SUV39H1 and... -
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- Functional Prediction of Hypothetical Proteins from Shigella flexneri and Validation of the Predicted Models by Using ROC Curve Analysis
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Gazi MA, Mahmud S, Fahim SM, Kibria MG, Palit P, Islam MR, Rashid H, Das S, Mahfuz M, Ahmeed T
- KMID: 2439216
- Genomics Inform.
- 2018 Dec;16(4):e26.
- doi: 10.5808/GI.2018.16.4.e26
Shigella spp. constitutes some of the key pathogens responsible for the global burden of diarrhoeal disease. With over 164 million reported cases per annum, shigellosis accounts for 1.1 million deaths... -
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- S100A4 Gene is Crucial for Methionine-Choline-Deficient Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice
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Zhang YH, Ma DQ, Ding DP, Li J, Chen LL, Ao KJ, Tian YY
- KMID: 2422491
- Yonsei Med J.
- 2018 Nov;59(9):1064-1071.
- doi: 10.3349/ymj.2018.59.9.1064
PURPOSE: To explore the influence of S100 calcium binding protein A4 (S100A4) knockout (KO) on methionine-choline-deficient (MCD) diet-induced non-alcoholic fatty liver disease (NAFLD) in mice. MATERIALS AND METHODS: S100A4 KO mice... -
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- The Prognostic Significance of Notch1 and Fatty Acid Binding Protein 7 (FABP7) Expression in Resected Tracheobronchial Adenoid Cystic Carcinoma: A Multicenter Retrospective Study
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Xie M, Wu X, Zhang J, He C, Wei S, Huang J, Fu X, Gu Y
- KMID: 2424779
- Cancer Res Treat.
- 2018 Oct;50(4):1064-1073.
- doi: 10.4143/crt.2017.337
PURPOSE: Adenoid cystic carcinoma (ACC) of the trachea and bronchus is a rare tumor. Although MYB-NFIB oncogene fusion and Notch1 mutation have been identified in ACC, little is known about... -
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- Differential Expression of Ca²âº-buffering Protein Calretinin in Cochlear Afferent Fibers: A Possible Link to Vulnerability to Traumatic Noise
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Sharma K, Seo YW, Yi E
- KMID: 2424734
- Exp Neurobiol.
- 2018 Oct;27(5):397-407.
- doi: 10.5607/en.2018.27.5.397
The synaptic contacts of cochlear afferent fibers (CAFs) with inner hair cells (IHCs) are spatially segregated according to their firing properties. CAFs also exhibit spatially segregated vulnerabilities to noise. The... -
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- Benzodiazepine-Associated Carcinogenesis: Focus on Lorazepam-Associated Cancer Biomarker Changes in Overweight Individuals
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Ku SC, Ho PS, Tseng YT, Yeh TC, Cheng SL, Liang CS
- KMID: 2424023
- Psychiatry Investig.
- 2018 Sep;15(9):900-906.
- doi: 10.30773/pi.2018.05.02.1
OBJECTIVE: Cellular, animal, and human epidemiological studies suggested that benzodiazepines increase the risk of cancer and cancer mortality. Obesity is also clearly linked to carcinogenesis. However, no human studies have... -
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