J Korean Pediatr Soc.  1982 Jun;25(6):541-546.

Developmental Changes of Membrane Proteins from Human Erythrocytes

• Joo CU
• Lee HS
• Kim JS
• Kim KC
• Kim HR

Abstract

To investigate the developmental changes of human erythrocytes, adult and fetal erythrocyte membranes prepared from adult and cord blood were analyzed in regard to their proteins, glycoproteins, enzyme activities and glucose transport systems. 1. Adult and fetal erythrocyte membranes appeared to have the same major proteins and gl-ycoproteins in the electrophoretic pattern. 2. ATPase activity in adult erythrocyte membranes was lower than that of fetal erythrocyte membranes, whereas adult cholinesterase was higher. No significant change was observed in the activities of alkaline and acid phosphatases during development. 3. Glucose uptake was higher in fetal erythrocytes than in adult erythrocytes, suggesting some loss of glucose carrier system during devlopment. The results suggest that the major structural proteins in human erythrocyte membrane relatively unchanged while some functional proteins such as membrane enzymes and carrier proteins in transport systems are markedly changed during development.

Keyword

Membrane Proteins; Human Erythrocytes

MeSH Terms

Adenosine Triphosphatases
Adult
Carrier Proteins
Cholinesterases
Erythrocyte Membrane
Erythrocytes*
Fetal Blood
Glucose
Glycoproteins
Humans*
Membrane Proteins*
Membranes*
Phosphoric Monoester Hydrolases
Adenosine Triphosphatases
Carrier Proteins
Cholinesterases
Glucose
Glycoproteins
Membrane Proteins
Phosphoric Monoester Hydrolases