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A suspected sugammadex-induced anaphylactic shock: A case report

Koo BS, Lee SJ, Na HW, Kang WB, Kim SH

BACKGROUND: The reversal of a neuromuscular blockade has typically been achieved with a cholinesterase inhibitor and the concomitant use of an anticholinergic agent, and this remains a popular method. Since...
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Chemical Constituents from Solenostemma argel and their Cholinesterase Inhibitory Activity

Demmak RG, Bordage S, Bensegueni A, Boutaghane N, Hennebelle T, Mokrani EH, Sahpaz S

Alzheimer's disease is a chronic neurodegenerative disorder with no curative treatment. The commercially available drugs, which target acetylcholinesterase, are not satisfactory. The aim of this study was to investigate the...
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Usefulness of serum lactate as a predictor of successful discontinuation of continuous atropine infusion in patients with severe acute organophosphate poisoning

Kwon HC, Cha YS, An GJ, Lee Y, Kim H

OBJECTIVE: In severe organophosphate (OP) poisoning, administration of atropine via continuous intravenous infusion is typically considered. To date, there have been no studies on predicting successful atropine discontinuation through plasma...
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Inhibitory effect of the leaves and stems of Actinidia arguta on Aβ (25–35)-induced neuronal cell death and memory impairment

Kang SG, Seong YH

Actinidia arguta (Actinidiaceae), which is commonly referred to as hardy kiwifruit, has been reported to possess anti-inflammatory, anti-allergic and antioxidative properties. The protective effect of the leaves and stems of...
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Garcinexanthone G, a Selective Butyrylcholinesterase Inhibitor from the Stem Bark of Garcinia atroviridis

Khaw KY, Murugaiyah V, Khairuddean M, Tan WN

The present study was undertaken to investigate the isolated compounds from the stem bark of Garcinia atroviridis as potential cholinesterase inhibitors and the ligand-enzyme interactions of selected bioactive compounds in...
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Isolation of Flavonoid Glycosides with Cholinesterase Inhibition Activity and Quantification from Stachys japonica

Nugroho A, Choi JS, Seong SH, Song BM, Park KS, Park HJ

The three flavone glycosides, 4′-O-methylisoscutellarein 7-O-(6‴-O-acetyl)-β-D-allopyranosyl(1→2)-β-D-glucopyranoside (1), isoscutellarein 7-O-(6‴-O-acetyl)-β-D-allopyranosyl(1→2)-β-D-glucopyranoside (3), and isoscutellarein 7-O-β-D-allopyranosyl(1→2)-β-D-glucopyranoside (4) in addition to a flavonol glycoside, kaempferol 3-O-β-D-glucopyranoside (astragalin, 2), were isolated from Stachys japonica (Lamiaceae)....
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Relative Risk and Clinical Severity Assessment in Patients with Non-Oral Route Organophosphate Poisoning Compared with Oral Route Poisoning

Jung WJ, Yu MH, Lee Y, Kim H, Cha YS, Park KH

PURPOSE: Organophosphates, commonly used in agricultural pesticides, pose high risks and incidences of poisoning. In the present study, we investigated the relative risk and clinical severity, including laboratory results, of...
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Pneumatosis Cystoides Intestinales and Portomesenteric Venous Gas following Anticholinesterase Pesticide Poisoning

Lee SH, Lee KW, Jung JH

Pneumatosis cystoides intestinalis and portomesenteric venous gas are uncommon radiological findings, but are found commonly in cases of bowel ischemia, or as a result of various non-ischemic conditions. A 72-year-old...
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Factors that affect the onset of action of non-depolarizing neuromuscular blocking agents

Kim YB, Sung TY, Yang HS

Neuromuscular blockade plays an important role in the safe management of patient airways, surgical field improvement, and respiratory care. Rapid-sequence induction of anesthesia is indispensable to emergency surgery and obstetric...
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Efficacy of Galantamine on Cognition in Mild-to-Moderate Alzheimer's Dementia after Failure to Respond to Donepezil

Hwang TY, Ahn IS, Kim S, Kim DK

OBJECTIVE: This study compares the efficacy of the cholinesterase inhibitor (ChEI) galantamine on cognition in patients with mild-to-moderate Alzheimer's dementia (AD) who were either naïve to ChEI drugs or who...
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Evaluation of Antioxidant, Anti-cholinesterase, and Anti-inflammatory Effects of Culinary Mushroom Pleurotus pulmonarius

Nguyen TK, Im KH, Choi J, Shin PG, Lee TS

Culinary mushroom Pleurotus pulmonarius has been popular in Asian countries. In this study, the anti-oxidant, cholinesterase, and inflammation inhibitory activities of methanol extract (ME) of fruiting bodies of P. pulmonarius...
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Effect of Alcohol on Death Rate in Organophosphate Poisoned Patients

Min YH, Park SM, Lee KJ, Oh YT, Ahn HC, Sohn YD, Ahn JY, Lee YH, Ha SO, Kim YJ

  • KMID: 1846319
  • J Korean Soc Clin Toxicol.
  • 2015 Jun;13(1):19-24.
PURPOSE: Many patients who are acutely poisoned with organophosphorus pesticides have co-ingested alcohol. The purpose of this study was to identify the factors that influence mortality in organophosphate intoxication and...
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Regulation of Gastric Electrical and Mechanical Activity by Cholinesterases in Mice

Worth AA, Forrest AS, Peri LE, Ward SM, Hennig GW, Sanders KM

  • KMID: 2381252
  • J Neurogastroenterol Motil.
  • 2015 Apr;21(2):200-216.
  • doi: 10.5056/jnm14120
BACKGROUND/AIMS: Gastric peristalsis begins in the orad corpus and propagates to the pylorus. Directionality of peristalsis depends upon orderly generation and propagation of electrical slow waves and a frequency gradient...
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Total Cholesterol Level for Assessing Pancreatic Insufficiency Due to Chronic Pancreatitis

Hirano K, Saito T, Mizuno S, Tada M, Sasahira N, Isayama H, Matsukawa , Umefune G, Akiyama D, Saito K, Kawahata S, Takahara N, Uchino R, Hamada T, Miyabayashi K, Mohri D, Sasaki T, Kogure H, Yamamoto N, Nakai Y, Koike K

BACKGROUND/AIMS: To determine the nutritional markers important for assessing the degree of pancreatic insufficiency due to chronic pancreatitis in routine clinical practice. METHODS: A total of 137 patients with chronic pancreatitis...
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New Evidences of Neurotoxicity of Aroclor 1254 in Mice Brain: Potential of Coenzyme Q10 in Abating the Detrimental Outcomes

Majumdar A, Nirwane A, Kamble R

  • KMID: 2380094
  • Environ Health Toxicol.
  • 2014 ;29(1):e2014001.
OBJECTIVES: The present subacute study was designed to evaluate the effect of coenzyme Q 10 (CoQ10) in the 28 days aroclor 1254 exposure induced oxidative stress in mice brain. METHODS: Biochemical...
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The Features and Prognoses in Organophosphate Intoxication according to Age

Lim SW, Park SM, Lee YH, Lee WW, Ahn JY, Sohn YD, Ahn HC, Kim H

BACKGROUND: The purpose of this study was to identify the factors that influence mortality in organophosphate intoxication and the differences between the elderly (> or =65 years) and younger adults...
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Antidote for organophosphate insecticide poisoning: atropine and pralidoxime

Chung SP, Roh HK

Acute organophosphate (OP) poisoning produces cholinergic symptoms resulting from the inhibition of cholinesterase, and the overstimulation of muscarinic and nicotinic receptors in the synapses. The dominant clinical features of acute...
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Initial Laboratory Parameters and its Correlation to Intermediate Syndrome in Patients with Acute Organophosphate Poisoning

Lee WK, Chun BJ, Moon JM, Lee SM, Jung YH, Lee BK, Ryu HH, Jeung KW, Heo T, Min YI

  • KMID: 2191966
  • J Korean Soc Emerg Med.
  • 2013 Oct;24(5):557-565.
PURPOSE: The association of serial serum cholinesterase (SChE) activity and the occurrence of intermediate syndrome (IMS) in patients orally poisoned with organophosphate (OP) were investigated. In addition, other clinical and...
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Muscle Relaxants in Critically Ill Patients with Renal Disease

Chon JY

Critical illness often results in renal dysfunction. Renal disease includes acid base imbalance, electrolyte shift and neuromuscular disturbances in critically ill patients, who are influenced by the pharmacodynamics and pharmacokinetics...
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Basal Level of Cholinesterase in a Population of Residents Over 60 Years Old in Jeju

Park KH, Kim WJ, Kang YJ, Park JH, Park JO, Kim H

  • KMID: 2192128
  • J Korean Soc Emerg Med.
  • 2012 Jun;23(3):383-388.
PURPOSE: Measurement of pseudocholinesterase (PChE) is a simple test for evaluation of the severity of intoxication with organophosphate and carbamate insecticides, because they inhibit PChE; however, as demonstrated in several...
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