- Fyn Tyrosine Kinase-mediated Tyrosine Phosphorylation of Roundabout (Robo), the Slit Receptor
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Jeon ES, Bae KW, Park HT
- KMID: 2224507
- Korean J Anat.
- 2004 Jun;37(3):275-281.
In this study, the molecular mechanism of tyrosine phosphorylation of Roundabout (Robo), the transmembrane receptor for slits, was investigated. The tyrosine phosphorylation of intracellular portion of Robo was increased by... -
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- Developmental Changes of Membrane Proteins from Human Erythrocytes
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Joo CU, Lee HS, Kim JS, Kim KC, Kim HR
- KMID: 1699464
- J Korean Pediatr Soc.
- 1982 Jun;25(6):541-546.
To investigate the developmental changes of human erythrocytes, adult and fetal erythrocyte membranes prepared from adult and cord blood were analyzed in regard to their proteins, glycoproteins, enzyme activities and... -
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- Regulatory Roles of MAPK Phosphatases in Cancer
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Low HB, Zhang Y
- KMID: 2168049
- Immune Netw.
- 2016 Apr;16(2):85-98.
- doi: 10.4110/in.2016.16.2.85
The mitogen-activated protein kinases (MAPKs) are key regulators of cell growth and survival in physiological and pathological processes. Aberrant MAPK signaling plays a critical role in the development and progression... -
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- CysQ of Cryptosporidium parvum, a Protozoa, May Have Been Acquired from Bacteria by Horizontal Gene Transfer
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Lee JY, Kim S
- KMID: 2053279
- Genomics Inform.
- 2012 Mar;10(1):9-15.
- doi: 10.5808/GI.2012.10.1.9
Horizontal gene transfer (HGT) is the movement of genetic material between kingdoms and is considered to play a positive role in adaptation. Cryptosporidium parvum is a parasitic protozoan that causes... -
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- Roles of Protein Arginine Methyltransferases in the Control of Glucose Metabolism
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Han HS, Choi D, Choi S, Koo SH
- KMID: 2384238
- Endocrinol Metab.
- 2014 Dec;29(4):435-440.
- doi: 10.3803/EnM.2014.29.4.435
Glucose homeostasis is tightly controlled by the regulation of glucose production in the liver and glucose uptake into peripheral tissues, such as skeletal muscle and adipose tissue. Under prolonged fasting,... -
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- A study on cytocompatibility of ion beam-irradiated chitosan sponges
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Ku Y
- KMID: 2014679
- J Korean Acad Periodontol.
- 1998 Jun;28(2):281-290.
- doi: 10.5051/jkape.1998.28.2.281
Chitosan is a biodegradable and non-toxic material with a molecular weight of 800-1,500Kd which can be obtained in various forms with extraordinary chemical structures and biological characteristics of which enables... -
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- Effect of Inositol-phosphatase on Fc Receptor-mediated Phagocytosis of Macrophages
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Kim JH
- KMID: 2150609
- Immune Netw.
- 2005 Sep;5(3):144-149.
- doi: 10.4110/in.2005.5.3.144
BACKGROUND: Fc receptor-mediated phagocytosis is a complex process involving the activation of kinases and phosphatases. FcgammaRIIB has been known to transduces inhibitory signals through an immunoreceptor tyrosine-based inhibitory motif (ITIM)... -
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- Phosphorylation of chicken protein tyrosine phosphatase 1 by casein kinase II in vitro
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Jung EJ, Kang KR, Kang YS
- KMID: 1532667
- Exp Mol Med.
- 1997 Dec;29(4):229-233.
The phosphorylation and dephosphorylation of proteins on tyrosyl residues are key regulatory mechanisms of cell growth and signal transduction and are controlled by opposing activities of protein tyrosine kinases and... -
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- Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers
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Jeoung NH
- KMID: 2281531
- Diabetes Metab J.
- 2015 Jun;39(3):188-197.
- doi: 10.4093/dmj.2015.39.3.188
Impaired glucose homeostasis is one of the risk factors for causing metabolic diseases including obesity, type 2 diabetes, and cancers. In glucose metabolism, pyruvate dehydrogenase complex (PDC) mediates a major... -
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- Connecting the dots between SHP2 and glutamate receptors
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Ryu HH, Kim SY, Lee YS
- KMID: 2471034
- Korean J Physiol Pharmacol.
- 2020 Mar;24(2):129-135.
- doi: 10.4196/kjpp.2020.24.2.129
SHP2 is an unusual protein phosphatase that functions as an activator for several signaling pathways, including the RAS pathway, while most other phosphatases suppress their downstream signaling cascades. The physiological... -
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- Serotonin Transporter and Pharmacotherapy
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Kim SJ, Seok JH, Kim CH
- KMID: 2287361
- Korean J Psychopharmacol.
- 2006 May;17(3):263-272.
The serotonin transporter (SERT) is the target site for serotonin reuptake inhibitors, which are the most widely used agents for treating various psychiatric diseases including depression. The SERT is a... -
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- Somatostatin Receptors in Lung Cancer: From Function to Molecular Imaging and Therapeutics
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Callison J, Walker RC, Massion PP
- KMID: 2005737
- J Lung Cancer.
- 2011 Dec;10(2):69-76.
- doi: 10.6058/jlc.2011.10.2.69
Lung cancer is a deadly disease that is difficult to diagnose and even more difficult to treat effectively. Many pathways are known to affect tumor growth, and targeting these pathways... -
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- Control of Inflammatory Responses: a New Paradigm for the Treatment of Chronic Neuronal Diseases
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Woo JH, Lee JH, Kim H, Park SJ, Joe EH, Jou I
- KMID: 2165543
- Exp Neurobiol.
- 2015 Jun;24(2):95-102.
- doi: 10.5607/en.2015.24.2.95
The term 'inflammation' was first introduced by Celsus almost 2000 years ago. Biological and medical researchers have shown increasing interest in inflammation over the past few decades, in part due... -
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- The effects of pregnancy on alveolar bone turnover during experimental tooth movement in rats
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Kim YS, Lee KS
- KMID: 2074762
- Korean J Orthod.
- 2000 Aug;30(4):413-421.
The purpose of this study was to observe the effects of pregnancy on the experimental tooth movement and alveolar bone turnover process of Sprague-Dawley female rat. Sixty rats were divided... -
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- Role of Pyruvate Dehydrogenase Kinase 4 in Regulation of Blood Glucose Levels
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Jeoung NH, Harris RA
- KMID: 2029884
- Korean Diabetes J.
- 2010 Oct;34(5):274-283.
- doi: 10.4093/kdj.2010.34.5.274
In the well-fed state a relatively high activity of the pyruvate dehydrogenase complex (PDC) reduces blood glucose levels by directing the carbon of pyruvate into the citric acid cycle. In... -
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- Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism
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Park S, Jeon JH, Min BK, Ha CM, Thoudam T, Park BY, Lee IK
- KMID: 2418715
- Diabetes Metab J.
- 2018 Aug;42(4):270-281.
- doi: 10.4093/dmj.2018.0101
Mitochondrial dysfunction is a hallmark of metabolic diseases such as obesity, type 2 diabetes mellitus, neurodegenerative diseases, and cancers. Dysfunction occurs in part because of altered regulation of the mitochondrial... -
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- The Role of Protein Phosphorylation in the Gustatory Cortex and Amygdala During Taste Learning
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Adaikkan C, Rosenblum
- KMID: 1438548
- Exp Neurobiol.
- 2012 Jun;21(2):37-51.
- doi: 10.5607/en.2012.21.2.37
Protein phosphorylation and dephosphorylation form a major post-translation mechanism that enables a given cell to respond to ever-changing internal and external environments. Neurons, similarly to any other cells, use protein... -
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- LRRK2 Inhibits FAK Activity by Promoting FERM-mediated Autoinhibition of FAK and Recruiting the Tyrosine Phosphatase, SHP-2
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Choi I, Byun JW, Park SM, Jou I, Joe EH
- KMID: 2354880
- Exp Neurobiol.
- 2016 Oct;25(5):269-276.
- doi: 10.5607/en.2016.25.5.269
Mutation of leucine-rich repeat kinase 2 (LRRK2) causes an autosomal dominant and late-onset familial Parkinson's disease (PD). Recently, we reported that LRRK2 directly binds to and phosphorylates the threonine 474... -
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- Evaluation of Challenges in Diagnosis of Spontaneous Subacute Pyogenic Spondylodiscitis in Immunocompetent Patients: Experiences from a Tertiary Care Center
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Pandita N, Paul S, Yadav G, Kalia RB, Kandwal P
- KMID: 2455653
- Asian Spine J.
- 2019 Aug;13(4):621-629.
- doi: 10.31616/asj.2018.0220
STUDY DESIGN: Prospective clinical study. PURPOSE: We evaluated the challenges faced during diagnosis and management of patients with subacute pyogenic discitis and discussed various clues in clinical history, radiologic and hematologic... -
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- Anti-IgE mAb Suppresses Systemic Anaphylaxis through the Inhibitory IgG Receptor FcgammaRIIb in Mice: Interaction between Anti-IgE and FcgammaRIIb
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Kang NI, Jin ZW, Lee HK
- KMID: 1513200
- Immune Netw.
- 2007 Sep;7(3):141-148.
- doi: 10.4110/in.2007.7.3.141
BACKGROUND: Anti-IgE mAb which binds circulating but not receptor-bound IgE has been shown to be effective in treatment for asthma and other allergic diseases. However, the mechanisms by which anti-IgE... -
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