Ann Lab Med.  2016 Jan;36(1):73-75. 10.3343/alm.2016.36.1.73.

Role of sul2 Gene Linked to Transposase in Resistance to Trimethoprim/Sulfamethoxazole Among Stenotrophomonas maltophilia Isolates

Affiliations
  • 1Department of Infectious Diseases, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. lijiabin948@vip.sohu.com
  • 2Anhui Center for Surveillance of Bacterial Resistance, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
  • 3Department of Center Laboratory, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
  • 4Department of Infectious Diseases, the Chaohu Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.

Abstract

No abstract available.


MeSH Terms

Anti-Bacterial Agents/*pharmacology
Bacterial Proteins/*genetics
Carrier Proteins/*genetics
Drug Resistance, Multiple, Bacterial/*genetics
Humans
Stenotrophomonas maltophilia/drug effects/*genetics/isolation & purification
Transposases/*genetics
Trimethoprim, Sulfamethoxazole Drug Combination/*pharmacology
Anti-Bacterial Agents
Bacterial Proteins
Carrier Proteins
Transposases
Trimethoprim, Sulfamethoxazole Drug Combination

Figure

  • Fig. 1 Schematic diagram of nucleotides flanking the sul2 gene.


Reference

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3. Hu LF, Chang X, Ye Y, Wang ZX, Shao YB, Shi W, et al. Stenotrophomonas maltophilia resistance to trimethoprim/sulfamethoxazole mediated by acquisition of sul and dfrA genes in a plasmid-mediated class 1 integron. Int J Antimicrob Agents. 2011; 37:230–234. PMID: 21296557.
4. Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing. Twenty-third informational supplement, M100-S23. Wayne, PA: CLSI;2013.
5. Toleman MA, Bennett PM, Bennett DM, Jones RN, Walsh TR. Global emergence of trimethoprim/sulfamethoxazole resistance in Stenotrophomonas maltophilia mediated by acquisition of sul genes. Emerg Infect Dis. 2007; 13:559–565. PMID: 17553270.
6. Trinh Q, Zhu P, Shi H, Xu W, Hao J, Luo Y, et al. A-T linker adapter polymerase chain reaction for determining flanking sequences by rescuing inverse PCR or thermal asymmetric interlaced PCR products. Anal Biochem. 2014; 466:24–26. PMID: 25086366.
7. Nazik H, Ongen B, Erturan Z, Salcioğlu M. Genotype and antibiotic susceptibility patterns of Pseudonas aeruginosa and Stenotrophomonas maltophilia isolated from cystic fibrosis patients. Jpn J Infect Dis. 2007; 60:82–86. PMID: 17515637.
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