Korean J Anat.
2005 Aug;38(4):363-370.
Differential Effects of Antipsychotic Drugs on Dopamine D1 and D2 Receptor mRNAs in the Rat Brain
- Affiliations
-
- 1Department of Biology, College of Natural Sciences, Gyeongsang National University, Chinju 660-751, Korea.
- 2Department of Anatomy, College of Medicine, Gyeongsang National University, Chinju 660-751, Korea. choiws@nongae.gsnu.ac.kr
- 3Department of Occupational Therapy, College of Biomedical science and Engineering, Inje University, GimHae, 621-749, South Korea.
Abstract
- The principal aim of this study was to determine the effects of antipsychotics (haloperidol, sulpiride, and clozapine) on regulating dopamine (DA) D1 and D2 receptor mRNA levels in the rat caudate putamen (CPu), nucleus accumbens (NAc), and olfactory tubercle (OTu). Twenty male Sprague-Dawley rats (250 g) were treated with haloperidol (1mg/mL), sulpiride (40 mg/mL), clozapine (20 mg/mL), and the control group received only water. Drugs were administered orally for 4 weeks. Antipsychotic drugs had differential effects on DA D1 and D2 receptor gene expression. Haloperidol and sulpiride induced an increase of DA D1 and D2 receptor mRNA levels in the rat CPu, OTu, and NAc; haloperidol caused a greater increase than sulpiride. However, clozapine treatment had less effect on DA receptor mRNAs levels in the same area. Antipsychotic drugs differentially upregulated the expression of DA D1 and D2 receptor mRNAs in the rat brain. These changes may be related, at least in part, to changes of DA concentration following antipsychotics treatment.
MeSH Terms
-
Animals
Antipsychotic Agents*
Brain*
Clozapine
Dopamine*
Gene Expression
Haloperidol
Humans
In Situ Hybridization
Male
Nucleus Accumbens
Olfactory Pathways
Putamen
Rats*
Rats, Sprague-Dawley
Receptors, Dopamine
RNA, Messenger*
Sulpiride
Water
Antipsychotic Agents
Clozapine
Dopamine
Haloperidol
RNA, Messenger
Receptors, Dopamine
Sulpiride
Water
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