- Effect of saccharin on inflammation in 3T3-L1 adipocytes and the related mechanism
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Kim HL, Ha AW, Kim WK
- KMID: 2471878
- Nutr Res Pract.
- 2020 Apr;14(2):109-116.
- doi: 10.4162/nrp.2020.14.2.109
BACKGROUND/OBJECTIVES: Excessive intake of simple sugars induces obesity and increases the risk of inflammation. Thus, interest in alternative sweeteners as a sugar substitute is increasing. The purpose of this study... -
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- Epigenetic Regulation of Filaggrin Gene Expression in Human Epidermal Keratinocytes
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Lee J, Jang A, Seo SJ, Myung SC
- KMID: 2471338
- Ann Dermatol.
- 2020 Apr;32(2):122-129.
- doi: 10.5021/ad.2020.32.2.122
BACKGROUND: Loss-of-function mutations in the filaggrin gene (FLG), which encodes an epidermal protein crucial for the formation of a functional skin barrier, have been identified as a major predisposing factor... -
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- Effects of Hydrogen Sulfide and Nitric Oxide on the Permeability of Cultured Trabecular Meshwork Cells
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Son MS, Baek MJ, Kim JW
- KMID: 2471767
- J Korean Ophthalmol Soc.
- 2020 Mar;61(3):267-273.
- doi: 10.3341/jkos.2020.61.3.267
PURPOSE: To investigate the effects of hydrogen sulfide (Hâ‚‚S) on the permeability of a cultured human trabecular meshwork cells (HTMC) monolayer and its interaction with nitric oxide (NO). METHODS: After exposing... -
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- Eupatilin downregulates phorbol 12-myristate 13-acetate-induced MUC5AC expression via inhibition of p38/ERK/JNK MAPKs signal pathway in human airway epithelial cells
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Cheon YH, Kim MS, Kim JY, Kim DH, Han SY, Lee JH
- KMID: 2471037
- Korean J Physiol Pharmacol.
- 2020 Mar;24(2):157-163.
- doi: 10.4196/kjpp.2020.24.2.157
Chronic inflammatory airway diseases, such as chronic rhinosinusitis, chronic obstructive pulmonary disease, and asthma, are associated with excessive mucus production. Hence, the regulation of mucus production is important for the... -
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- Inhibition of melanogenesis by sodium 2-mercaptoethanesulfonate
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Kim JH, Oh CT, Kwon TR, Kim JH, Bak DH, Kim H, Park WS, Kim BJ
- KMID: 2471036
- Korean J Physiol Pharmacol.
- 2020 Mar;24(2):149-156.
- doi: 10.4196/kjpp.2020.24.2.149
Sodium 2-mercaptoethanesulfonate (mesna) is a protective agent that is widely used in medicine because of its antioxidant effects. Recently, reactive oxygen species (ROS) were shown to increase pigmentation. Thus, ROS... -
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- The MicroRNA hsa-let-7g Promotes Proliferation and Inhibits Apoptosis in Lung Cancer by Targeting HOXB1
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Cui F, Zhou Q, Xiao K, Ma S
- KMID: 2470917
- Yonsei Med J.
- 2020 Mar;61(3):210-217.
- doi: 10.3349/ymj.2020.61.3.210
PURPOSE: The goal of this study was to explore the effects of hsa-let-7g on cell proliferation and apoptosis, and elucidate its role in lung cancer development. MATERIALS AND METHODS: The expression... -
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- Evidence for the Presence of Long-Lived Plasma Cells in Nasal Polyps
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Zhang YN, Song J, Zhai GT, Wang H, Luo RZ, Li JX, Liao B, Ma J, Wang H, Lu X, Liu DB, Liu Z
- KMID: 2468462
- Allergy Asthma Immunol Res.
- 2020 Mar;12(2):274-291.
- doi: 10.4168/aair.2020.12.2.274
PURPOSE: Plasma cells and immunoglobulins (Igs) play a pivotal role in the induction and maintenance of chronic inflammation in nasal polyps. During secondary immune responses, plasma cell survival and Ig... -
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- Upregulated Long Noncoding RNA LINC01234 Predicts Unfavorable Prognosis for Colorectal Cancer and Negatively Correlates With KLF6 Expression
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Jiang X, Zhu Q, Wu P, Zhou F, Chen J
- KMID: 2460913
- Ann Lab Med.
- 2020 Mar;40(2):155-163.
- doi: 10.3343/alm.2020.40.2.155
BACKGROUND: LINC01234, a long noncoding RNA (lncRNA), is overexpressed in several cancers, including colorectal cancer (CRC). We investigated the role of LINC01234 in CRC development and confirmed its correlation with... -
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- Effect of Diquafosol on Hyperosmotic Stress-induced Tumor Necrosis Factor-α and Interleukin-6 Expression in Human Corneal Epithelial Cells
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Kim YH, Yang IJ, Nguyen LT, Gum SI, Yu S, Lee GJ, Kim BA, Jung JC, Park YJ
- KMID: 2469281
- Korean J Ophthalmol.
- 2020 Feb;34(1):1-10.
- doi: 10.3341/kjo.2019.0046
PURPOSE: Diquafosol is a pharmaceutical drug used for dry eye treatment with a novel mechanism of action. It is a purinergic P2Y2 receptor agonist that promotes the secretion of tears... -
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- Curcumin Attenuates Acrolein-induced COX-2 Expression and Prostaglandin Production in Human Umbilical Vein Endothelial Cells
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Lee SE, Park HR, Jeon S, Han D, Park YS
- KMID: 2470810
- J Lipid Atheroscler.
- 2020 Jan;9(1):184-194.
- doi: 10.12997/jla.2020.9.1.184
OBJECTIVE: Inflammation is crucial to limiting vascular disease. Previously we reported that acrolein, a known toxin in tobacco smoke, might play an important role in the progression of atherosclerosis via... -
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- Quantifications of Lipid Kinetics In Vivo Using Stable Isotope Tracer Methodology
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Kim IY, Park S, Jang J, Wolfe RR
- KMID: 2470804
- J Lipid Atheroscler.
- 2020 Jan;9(1):110-123.
- doi: 10.12997/jla.2020.9.1.110
Like other bodily materials, lipids such as plasma triacylglycerol, cholesterols, and free fatty acids are in a dynamic state of constant turnover (i.e., synthesis, breakdown, oxidation, and/or conversion to other... -
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- mTOR-coordinated Post-Transcriptional Gene Regulations: from Fundamental to Pathogenic Insights
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Yeh HS, Yong J
- KMID: 2470798
- J Lipid Atheroscler.
- 2020 Jan;9(1):8-22.
- doi: 10.12997/jla.2020.9.1.8
Post-transcriptional regulations of mRNA transcripts such as alternative splicing and alternative polyadenylation can affect the expression of genes without changing the transcript levels. Recent studies have demonstrated that these post-transcriptional... -
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- Spatiotemporal expression of RCAN1 and its isoform RCAN1-4 in the mouse hippocampus after pilocarpine-induced status epilepticus
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Cho KO, Jeong KH, Cha JH, Kim SY
- KMID: 2466572
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):81-88.
- doi: 10.4196/kjpp.2020.24.1.81
Regulator of calcineurin 1 (RCAN1) can be induced by an intracellular calcium increase and oxidative stress, which are characteristic features of temporal lobe epilepsy. Thus, we investigated the spatiotemporal expression... -
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- Inhibitory effect of carvacrol on lipopolysaccharide-induced memory impairment in rats
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Lee B, Yeom M, Shim I, Lee H, Hahm DH
- KMID: 2466567
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):27-37.
- doi: 10.4196/kjpp.2020.24.1.27
Neuroinflammation is an important process underlying a wide variety of neurodegenerative diseases. Carvacrol (CAR) is a phenolic monoterpene commonly used as a food additive due to its antibacterial properties, but... -
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- Follistatin Mitigates Myofibroblast Differentiation and Collagen Synthesis of Fibroblasts from Scar Tissue around Injured Flexor Tendons
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Kang YM, Lee SK, Chun YM, Choi YR, Moon SH, Lee HM, Kang HJ
- KMID: 2466340
- Yonsei Med J.
- 2020 Jan;61(1):85-93.
- doi: 10.3349/ymj.2020.61.1.85
PURPOSE: The aim of this study was to investigate the effect of FST gene on the inhibition of fibrosis in fibroblastic cells from scar tissue around repaired zone II flexor... -
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- Curcumin Inhibits the Proliferation, Migration, Invasion, and Apoptosis of Diffuse Large B-Cell Lymphoma Cell Line by Regulating MiR-21/VHL Axis
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Chen L, Zhan CZ, Wang T, You H, Yao R
- KMID: 2466332
- Yonsei Med J.
- 2020 Jan;61(1):20-29.
- doi: 10.3349/ymj.2020.61.1.20
PURPOSE: Curcumin exerts its anti-cancer effects, partly by targeting special microRNAs, in human cancers. MiR-21 is a key oncomir in carcinogenesis of multiple human cancers. Here, we aimed to further... -
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- Particulate Matter 2.5 Causes Deficiency in Barrier Integrity in Human Nasal Epithelial Cells
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Xian M, Ma S, Wang K, Lou H, Wang Y, Zhang L, Wang C, Akdis CA
- KMID: 2462572
- Allergy Asthma Immunol Res.
- 2020 Jan;12(1):56-71.
- doi: 10.4168/aair.2020.12.1.56
PURPOSE: The effect of air pollution-related particulate matter (PM) on epithelial barrier function and tight junction (TJ) expression in human nasal mucosa has not been studied to date. This study... -
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- 15-Deoxy-Δ(12,14)-prostaglandin J₂ Upregulates the Expression of 15-Hydroxyprostaglandin Dehydrogenase by Inducing AP-1 Activation and Heme Oxygenase-1 Expression in Human Colon Cancer Cells
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Park JM, Na HK
- KMID: 2468800
- J Cancer Prev.
- 2019 Sep;24(3):183-191.
- doi: 10.15430/JCP.2019.24.3.183
BACKGROUND: Abnormal upregulation of prostaglandin Eâ‚‚ (PGEâ‚‚) is considered to be a key oncogenic event in the development and progression of inflammation-associated human colon cancer. It has been reported that... -
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- Involvement of Up-regulation of Death Receptors and Bim in Hispolon-mediated TNF-related Apoptosis-inducing Ligand Sensitization in Human Renal Carcinoma
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Yun JM, Min KJ, Kwon TK
- KMID: 2468797
- J Cancer Prev.
- 2019 Sep;24(3):155-162.
- doi: 10.15430/JCP.2019.24.3.155
BACKGROUND: Hispolon has been shown to possess antitumor effects in various cancer cells. However, the underlying mechanisms are not fully understood. In this study, we evaluated the sensitizing effect of... -
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- Regulation of porcine endogenous retrovirus by dual LTR1+2 (Long Terminal Region) miRNA in primary porcine kidney cells
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Chung HC, Nguyen VG, Moon HJ, Park YH, Park BK
- KMID: 2464096
- J Vet Sci.
- 2019 Sep;20(5):e50.
- doi: 10.4142/jvs.2019.20.e50
Porcine endogenous retroviruses (PERVs) integrate into germline DNA as proviral genome that enables vertical transmission from parents to their offspring. The provirus usually survives as part of the host genome... -
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