Korean J Psychopharmacol.  2004 Sep;15(3):255-262.

Modulation of Dopamine D2 Receptors as a Basis of Antipsychotic Action

• Kim YH
• Lee BJ

Abstract

As comparing to typical antipsychotics, atypical antipsychotics have several characters such as no causing catalepsy in animal models or extrapyramidal side effects in schizophrenia patients, no or transient prolactin elevation (except risperidone, amisulpride), effects on negative symptoms, mood and affective symptoms, and efficacy in refractory schizophrenia. In views of the results of several studies so far achieved, the action at the dopamine D2/3 receptors, is by itself, sufficient to provide the contemporary kind of atypical antipsychotic activity. This review will attempt to address the modulation of dopamine D2 receptors as a basis of atypical antipsychotic action by looking over dopamine receptor occupancy, differential effects at the striatal versus extrastriatal dopamine D2 receptor, D2 receptor affinity and Koff consideration, effects for psychotic symptoms.

Keyword

Dopamine; Receptor; Antipsychotic action; Atypical antipsychotic

MeSH Terms

Affective Symptoms
Antipsychotic Agents
Catalepsy
Dopamine*
Humans
Models, Animal
Prolactin
Receptors, Dopamine
Receptors, Dopamine D2*
Risperidone
Schizophrenia
Antipsychotic Agents
Dopamine
Prolactin
Receptors, Dopamine
Receptors, Dopamine D2
Risperidone