- YKP1447, A Novel Potential Atypical Antipsychotic Agent
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Dong SM, Kim YG, Heo J, Ji MK, Cho JW, Kwak BS
- KMID: 2071654
- Korean J Physiol Pharmacol.
- 2009 Apr;13(2):71-78.
- doi: 10.4196/kjpp.2009.13.2.71
(S)-Carbamic acid 2-[4-(4-fluoro-benzoyl)-piperidin-1-yl]-1-phenyl-ethyl ester hydrochloride (YKP1447) is a novel "atypical" antipsychotic drug which selectively binds to serotonin (5-HT2A, Ki=0.61 nM, 5-HT2C, Ki=20.7 nM) and dopamine (D2, Ki=45.9 nM, D3, Ki=42.1... -
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- Beneficial Effect of Vitamin E in Rotenone Induced Model of PD: Behavioural, Neurochemical and Biochemical Study
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Sharma N, Nehru B
- KMID: 2165484
- Exp Neurobiol.
- 2013 Sep;22(3):214-223.
- doi: 10.5607/en.2013.22.3.214
Parkinson's disease (PD) a neurodegenerative disorder for which no preventive or long-term effective treatment strategies are available. Epidemiologic studies have failed to identify specific environmental, dietary or lifestyle risk factors... -
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- Modulation of Dopamine D2 Receptors as a Basis of Antipsychotic Action
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Kim YH, Lee BJ
- KMID: 2286852
- Korean J Psychopharmacol.
- 2004 Sep;15(3):255-262.
As comparing to typical antipsychotics, atypical antipsychotics have several characters such as no causing catalepsy in animal models or extrapyramidal side effects in schizophrenia patients, no or transient prolactin elevation (except risperidone,... -
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- Experimental Models of Schizophrenia
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Cheon JS
- KMID: 2334614
- J Korean Soc Biol Psychiatry.
- 1999 Nov;6(2):153-160.
Animal models can provide a useful tool for the study of some aspects of psychiatric disorders and their treatment. The four criteria for the evaluation of animal models of psychiatric... -
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- The Effect of Ketamine on the Intestinal Motility of the Chicken
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Koh SO, Kim JR, Park KW, Kim WJ
- KMID: 2357565
- Korean J Anesthesiol.
- 1979 Jun;12(2):121-128.
In the late 1950, Greifenstein and associates have studied the properties of phenylcyelohexylamine derivatives and reported that these chemicals produced amnesia, analgesia, catatonia and catalepsy. Phencyclidine was the first of... -
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