- Therapeutic Effect of a Novel Chimeric Molecule Targeting Both Somatostatin and Dopamine Receptors on Growth Hormone-Secreting Pituitary Adenomas
-
Kim J, Oh JH, Harlem H, Culler MD, Ku CR, Lee EJ
- KMID: 2471734
- Endocrinol Metab.
- 2020 Mar;35(1):177-187.
- doi: 10.3803/EnM.2020.35.1.177
BACKGROUND: Acromegaly is a rare disease primarily caused by growth hormone (GH)-secreting pituitary adenomas, and its treatment is costly. Moreover, some patients are unresponsive to treatment. Hence, there are increasing... -
- CITED
-
- Close
- SHARE
-
- Close
- Role of Helix 8 in Dopamine Receptor Signaling
-
Yang HS, Sun N, Zhao X, Kim HR, Park HJ, Kim KM, Chung KY
- KMID: 2462878
- Biomol Ther.
- 2019 Nov;27(6):514-521.
- doi: 10.4062/biomolther.2019.026
G protein-coupled receptors (GPCRs) are membrane receptors whose agonist-induced dynamic conformational changes trigger heterotrimeric G protein activation, followed by GRK-mediated phosphorylation and arrestin-mediated desensitization. Cytosolic regions of GPCRs have been... -
- CITED
-
- Close
- SHARE
-
- Close
- Combination of In Vivo [¹²³I]FP-CIT SPECT and Microdialysis Reveals an Antipsychotic Drug Haloperidol-induced Synaptic Dopamine Availability in the Rat Midbrain and Striatum
-
Park SH, Song YS, Moon BS, Lee BC, Park HS, Kim SE
- KMID: 2463715
- Exp Neurobiol.
- 2019 Oct;28(5):602-611.
- doi: 10.5607/en.2019.28.5.602
Synaptic dopamine (DA) is mainly regulated by the presynaptic DA transporter (DAT). Single-photon emission computerized tomography (SPECT) with the DAT radiotracer [¹²³I]FP-CIT assesses changes in synaptic DA availability when endogenous... -
- CITED
-
- Close
- SHARE
-
- Close
- Long-term Effects of Aripiprazole Treatment during Adolescence on Cognitive Function and Dopamine D2 Receptor Expression in Neurodevelopmentally Normal Rats
-
Choi HJ, Im SJ, Park HR, Park S, Kim CE, Ryu S
- KMID: 2457403
- Clin Psychopharmacol Neurosci.
- 2019 Aug;17(3):400-408.
- doi: 10.9758/cpn.2019.17.3.400
OBJECTIVE: This study aimed to investigate the long-term effects of aripiprazole treatment during adolescence on behavior, cognitive function, and dopamine D2 receptor (D2R) expression in adult rats. METHODS: Adolescent male Sprague-Dawley... -
- CITED
-
- Close
- SHARE
-
- Close
- Limonene Inhibits Methamphetamine-Induced Sensitizations via the Regulation of Dopamine Receptor Supersensitivity
-
Gu SM, Kim SY, Lamichhane S, Hong JT, Yun J
- KMID: 2455090
- Biomol Ther.
- 2019 Jul;27(4):357-362.
- doi: 10.4062/biomolther.2018.213
Limonene is a cyclic terpene found in citrus essential oils and inhibits methamphetamine-induced locomotor activity. Drug dependence is a severe neuropsychiatric condition that depends in part on changes in neurotransmission... -
- CITED
-
- Close
- SHARE
-
- Close
- Reduced Uptake on Dopamine Transporter Imaging by Methylphenidate
-
Ha J, Ko J, Song JT, Hong JY
- KMID: 2454854
- J Korean Neurol Assoc.
- 2019 May;37(2):206-208.
- doi: 10.17340/jkna.2019.2.19
No abstract available. -
- CITED
-
- Close
- SHARE
-
- Close
- Heterogeneous Patterns of Striatal Dopamine Loss in Patients with Young- versus Old-Onset Parkinson's Disease: Impact on Clinical Features
-
Chung SJ, Yoo HS, Lee YH, Lee PH, Sohn YH
- KMID: 2449683
- J Mov Disord.
- 2019 May;12(2):113-119.
- doi: 10.14802/jmd.18064
OBJECTIVE: Ample evidence has suggested that age at onset of Parkinson's disease (PD) is associated with heterogeneous clinical features in individuals. We hypothesized that this may be attributed to different... -
- CITED
-
- Close
- SHARE
-
- Close
- Nonmotor and Dopamine Transporter Change in REM Sleep Behavior Disorder by Olfactory Impairment
-
Lee JY, Yoon EJ, Kim YK, Shin CW, Nam H, Jeong JM, Kim HJ, Jeon B
- KMID: 2449682
- J Mov Disord.
- 2019 May;12(2):103-112.
- doi: 10.14802/jmd.18061
OBJECTIVE: It is unclear whether the decline in dopamine transporters (DAT) differs among idiopathic rapid eye movement sleep behavior disorder (iRBD) patients with different levels of olfactory impairment. This study... -
- CITED
-
- Close
- SHARE
-
- Close
- Delayed Treatment of Capsaicin Produces Partial Motor Recovery by Enhancing Dopamine Function in MPPâº-lesioned Rats via Ciliary Neurotrophic Factor
-
Kim KI, Baek JY, Jeong JY, Nam JH, Park ES, Bok E, Shin WH, Chung YC, Jin BK
- KMID: 2450220
- Exp Neurobiol.
- 2019 Apr;28(2):289-299.
- doi: 10.5607/en.2019.28.2.289
Transient receptor potential vanilloid subtype 1 (TRPV1) on astrocytes prevents ongoing degeneration of nigrostriatal dopamine (DA) neurons in MPPâº-lesioned rats via ciliary neurotrophic factor (CNTF). The present study determined whether... -
- CITED
-
- Close
- SHARE
-
- Close
- Effect of Single-Nucleotide Polymorphisms on Decline of Dopamine Transporter Availability in Parkinson's Disease
-
Shin S, Kim K, Lee JM, Kim EJ, Kim SJ, Kim IJ, Pak K, Lee MJ
- KMID: 2451152
- J Clin Neurol.
- 2019 Jan;15(1):102-107.
- doi: 10.3988/jcn.2019.15.1.102
BACKGROUND AND PURPOSE: We aimed to determine the association between the annual changes in dopamine transporter (DAT) availability as measured by 123I-ioflupane (123I-FP-CIT) single-photon-emission computed tomography and single-nucleotide polymorphisms (SNPs)... -
- CITED
-
- Close
- SHARE
-
- Close
- Regional difference in spontaneous firing inhibition by GABA(A) and GABA(B) receptors in nigral dopamine neurons
-
Kim Y, Jang J, Kim HJ, Park MK
- KMID: 2430095
- Korean J Physiol Pharmacol.
- 2018 Nov;22(6):721-729.
- doi: 10.4196/kjpp.2018.22.6.721
GABAergic control over dopamine (DA) neurons in the substantia nigra is crucial for determining firing rates and patterns. Although GABA activates both GABA(A) and GABA(B) receptors distributed throughout the somatodendritic... -
- CITED
-
- Close
- SHARE
-
- Close
- Consolidation of a Learned Skill Correlates with Dopamine SPECT Uptake in Early Parkinson's Disease
-
Nicastro N, Manuel AL, Garibotto , Burkhard P, Schnider A
- KMID: 2424179
- J Clin Neurol.
- 2018 Oct;14(4):505-512.
- doi: 10.3988/jcn.2018.14.4.505
BACKGROUND AND PURPOSE: Basal ganglia play a pivotal role in procedural memory. However, the correlation between skill learning and striatal 123I-ioflupane uptake in Parkinson's disease (PD) has not been reported... -
- CITED
-
- Close
- SHARE
-
- Close
- Interleukin-4 Contributes to Degeneration of Dopamine Neurons in the Lipopolysaccharide-treated Substantia Nigra in vivo
-
Bok E, Cho EJ, Chung ES, Shin WH, Jin BK
- KMID: 2419340
- Exp Neurobiol.
- 2018 Aug;27(4):309-319.
- doi: 10.5607/en.2018.27.4.309
The present study investigated the effects of interleukin (IL)-4 on dopamine (DA) neurons in the substantia nigra (SN) in vivo of lipopolysaccharide (LPS)-treated rat. Tyrosine hydroxylase immunohistochemistry showed a significant... -
- CITED
-
- Close
- SHARE
-
- Close
- Effect of rs3910105 in the Synuclein Gene on Dopamine Transporter Availability in Healthy Subjects
-
Seo Y, Pak K, Nam HY, Seok JW, Lee MJ, Kim EJ, Lee JM, Kim SJ, Kim IJ
- KMID: 2415538
- Yonsei Med J.
- 2018 Aug;59(6):787-792.
- doi: 10.3349/ymj.2018.59.6.787
PURPOSE: The present study investigated associations between dopamine transporter (DAT) availability and α-synuclein levels in cerebrospinal fluid, as well as synuclein gene (SNCA) transcripts, and the effect of single nucleotide... -
- CITED
-
- Close
- SHARE
-
- Close
- Ameliorative Effects of Ombuoside on Dopamine Biosynthesis in PC12 Cells
-
Davaasambuu U, Park KH, Park HJ, Choi HS, Lee CK, Hwang BY, Lee MK
- KMID: 2416069
- Nat Prod Sci.
- 2018 Jun;24(2):99-102.
- doi: 10.20307/nps.2018.24.2.99
This study investigated the effects of ombuoside, a flavonol glycoside, on dopamine biosynthesis in PC12 cells. Ombuoside at concentrations of 1, 5, and 10 µM increased intracellular dopamine levels at... -
- CITED
-
- Close
- SHARE
-
- Close
- Berberine alleviates symptoms of anxiety by enhancing dopamine expression in rats with post-traumatic stress disorder
-
Lee B, Shim I, Lee H, Hahm DH
- KMID: 2410108
- Korean J Physiol Pharmacol.
- 2018 Mar;22(2):183-192.
- doi: 10.4196/kjpp.2018.22.2.183
Post-traumatic stress disorder (PTSD) is a trauma-induced psychiatric disorder characterized by impaired fear extermination, hyperarousal, anxiety, depression, and amnesic symptoms that may involve the release of monoamines in the fear... -
- CITED
-
- Close
- SHARE
-
- Close
- Abnormal Dopamine Transporter Positron Emission Tomography Image Caused by Lesion on Nigrostriatal Tract
-
Hong JY
- KMID: 2435790
- J Korean Neurol Assoc.
- 2018 Feb;36(1):57-58.
- doi: 10.17340/jkna.2018.1.15
No abstract available. -
- CITED
-
- Close
- SHARE
-
- Close
- Investigation into the Possible Genetic Role of Serotonin and Dopamine Transporters in Psychological Resilience
-
Cho SH, Chung JK, Bang YW, Joo EJ
- KMID: 2434818
- Korean J Biol Psychiatry.
- 2018 Feb;25(1):16-20.
- doi: 10.0000/kjbp.2018.25.1.16
OBJECTIVES: Psychological resilience is the ability to cope with stress. The genetic background behind psychological resilience is not much known. The serotonin transporter and dopamine transporter are implicated in stress... -
- CITED
-
- Close
- SHARE
-
- Close
- MPTP-induced vulnerability of dopamine neurons in A53T α-synuclein overexpressed mice with the potential involvement of DJ-1 downregulation
-
Lee S, Oh ST, Jeong HJ, Pak SC, Park HJ, Kim J, Cho HS, Jeon S
- KMID: 2395257
- Korean J Physiol Pharmacol.
- 2017 Nov;21(6):625-632.
- doi: 10.4196/kjpp.2017.21.6.625
Familial Parkinson's disease (PD) has been linked to point mutations and duplication of the α-synuclein (α-syn) gene. Mutant α-syn expression increases the vulnerability of neurons to exogenous insults. In this... -
- CITED
-
- Close
- SHARE
-
- Close
- Abnormal Sleep Delta Rhythm and Interregional Phase Synchrony in Patients with Restless Legs Syndrome and Their Reversal by Dopamine Agonist Treatment
-
Choi JW, Jeong MH, Her SJ, Lee BU, Cha KS, Jung KY, Kim KH
- KMID: 2392129
- J Clin Neurol.
- 2017 Oct;13(4):340-350.
- doi: 10.3988/jcn.2017.13.4.340
BACKGROUND AND PURPOSE: The purpose of this study was to characterize abnormal cortical activity during sleep in restless legs syndrome (RLS) patients and to determine the effects of treatment with... -
- CITED
-
- Close
- SHARE
-
- Close
