J Korean Soc Biol Psychiatry.  1997 Nov;4(2):218-224.

Association between the Alleles of the Dopamine D, Receptor and Schizophrenia

• Kim JI
• Lee MS
• Kwak DI

Abstract

The results regarding an association between the polymorphism sites in the dopamine D1 receptor gene and schizophrenia compelled us to study the distribution of the polymorphism in Korean schizophrenia and controls. Eighty-eight schizophrenic patients and normal controls were examined by case-control study for distribution of the polymorphism of the dopamine D1 receptor gene in Korean popualtion to minimize the effect of racial differencies in gene frequencies. The frequencies of the B1 and B2 in schizophrenic patients were 0.11 and 9.89, respectively. And 0.10 and 0.90 in normal control. There was no significant differences in the frequencies in the allele B1 and 2 between schizophrenic patients and normal controls. The author present here the evidence of a lack of alleic association between the polymorphism of the dopamine D1 receptor gene and Korean schizophrenic. The assumption that the dopamine D1 receptor gene has genetic role in the development of schizophrenia was not supported by this case-control study.

MeSH Terms

Alleles*
Case-Control Studies
Dopamine*
Gene Frequency
Humans
Receptors, Dopamine D1
Receptors, Dopamine D2
Schizophrenia*
Dopamine
Receptors, Dopamine D1
Receptors, Dopamine D2