J Korean Soc Biol Psychiatry.  2001 Jun;8(1):116-122.

The Association between Polymorphism of the Dopamine D3 Receptors and Concentrations of Plasma Homovanillic and 5-hydroxyindoleacetic Acid, and Therapeutic Response of chronic Schizophrenic Patients

• Jeong GJ
• Lee MS
• Kim SY
• Kang DY
• Kwak DI

Abstract

OBJECTIVES
Schizophrenia manifests a variety of interindividual differences in therapeutic response to antipsychotics. This might be attributable to dopamine and serotonin receptors that a important target for various antipsychotics, and the D3 receptor(DRD3) alleles they carry. The purpose of our study was to investigate whether the plasma levels of homovanillic acid(HVA) and 5-hydroxyindoleacetic acid(HIAA), and the polymorphism of DRD3 can be held as a predictor of treatment response ni chronic schizophrenic patients.
METHODS
Therapeutic response for 16 korean schizophrenia patient treated during 48 weeks were assessed by PANSS used as the clinical symptom rating scales. The levels of concentration of HVA and 5-HIAA were examined by HPLC at baseline and at 48 weeks. We classified the polymorphism of DRD3 receptor using amplifying by polymerase chain reaction(PCR).
RESULTS
Neither concentrations of HVA and 5-HIAA nor genotype of dopamine 3 receptor were not significantly associated with the therapeutic response. But, the patients who has A1 alleles of DRD3 gene showed poor therapeutic responses.
CONCLUSION
A1 allele of DRD3 gene is associated with poor prognosis of chronic schizophrenia.

MeSH Terms

Alleles
Antipsychotic Agents
Chromatography, High Pressure Liquid
Dopamine*
Genotype
Homovanillic Acid
Humans
Hydroxyindoleacetic Acid
Plasma*
Prognosis
Receptors, Dopamine D3*
Receptors, Serotonin
Schizophrenia
Weights and Measures
Antipsychotic Agents
Dopamine
Homovanillic Acid
Hydroxyindoleacetic Acid
Receptors, Dopamine D3
Receptors, Serotonin