J Korean Soc Biol Psychiatry.  2000 Nov;7(2):159-163.

The Association between the Dopamine D5 Receptor Genotype and Treatment Response for Korean Schizophrenic Patients

• Kang SM
• Lee MS
• Rhee CS

Abstract

BACKGROUND: Dopamine receptors are strong candidates for involvement in schizophrenia and are target of a wide variety of antipsychotics. Dopamine D5 receptor(DRD5) gene polymorphisms may be associated with various treatment response. The purpose of our study was define to what significance can be held as a predictor of treatment response in this polymorphism. METHOD: The total number of 116 Korean chronic schizophrenic patients was assessed after 48 weeks treatment. The Positive and Negative Syndrome Scale(PANSS) was rated for the clinical response to various antipsychotics. With the use of polymerase chain reaction amplification, we assessed this dopamine D5 receptor polymorphism in schizophrenic patients who had been treated with antipsychotics, and related genotype with treatment response, to test the hypothesis that DRD5 polymorphism may lead to varying resonse to antipsychotic. RESULT: DRD5 polymorphism was not associated with treatment response to a variety of antipsychotics in chronic schizophrenic patients.
CONCLUSION
Genetic variation of D5 receptors do not predict treatment response to antispychotics.

MeSH Terms

Antipsychotic Agents
Dopamine*
Genetic Variation
Genotype*
Humans
Polymerase Chain Reaction
Receptors, Dopamine
Receptors, Dopamine D5*
Schizophrenia
Antipsychotic Agents
Dopamine
Receptors, Dopamine
Receptors, Dopamine D5