- Therapeutic Effect of a Novel Chimeric Molecule Targeting Both Somatostatin and Dopamine Receptors on Growth Hormone-Secreting Pituitary Adenomas
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Kim J, Oh JH, Harlem H, Culler MD, Ku CR, Lee EJ
- KMID: 2471734
- Endocrinol Metab.
- 2020 Mar;35(1):177-187.
- doi: 10.3803/EnM.2020.35.1.177
BACKGROUND: Acromegaly is a rare disease primarily caused by growth hormone (GH)-secreting pituitary adenomas, and its treatment is costly. Moreover, some patients are unresponsive to treatment. Hence, there are increasing... -
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- Chromosomal Deletion in 7q31.2-31.32 Involving Ca2âº-Dependent Activator Protein for Secretion Gene in a Patient with Cerebellar Ataxia: a Case Report
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Hong S, Lee SJ, Cho SR
- KMID: 2469629
- Brain Neurorehabil.
- 2020 Mar;13(1):e9.
- doi: 10.12786/bn.2020.13.e9
We present a 33-year-old male patient with cerebellar ataxia. He was first considered to have a psychiatric conversion disorder but finally found to have chromosomal deletion in 7q31.2-31.32 involving Ca2âº-dependent... -
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- Updates on the Diagnosis and Treatment of Restless Legs Syndrome
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Kang SG
- KMID: 2471260
- J Korean Neuropsychiatr Assoc.
- 2020 Feb;59(1):13-19.
- doi: 10.4306/jknpa.2020.59.1.13
Restless legs syndrome (RLS) is a neurological sleep disorder characterized by an urge to move the legs or arms and is associated with discomfort and paresthesia in the legs. RLS... -
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- Full mouth rehabilitation for a Parkinson's diseases patient with chronic periodontitis: a case report
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Koh ES, Kim JJ, Baik J, Cha HS, Lee JH
- KMID: 2470628
- J Dent Rehabil Appl Sci.
- 2019 Dec;35(4):228-234.
- doi: 10.14368/jdras.2019.35.4.228
Parkinson's disease is a neurological disorder characterized by tremor, bradykinesia, akinesia, postural instability, and muscular rigidity, which is caused by the depletion of neurotransmitters such as dopamine. Cooperative dental treatment... -
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- Efficacy of Asenapine in Schizophrenia Resistant to Clozapine Combined with Electroconvulsive Therapy: A Case Report
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Ochi S, Inoue S, Yoshino Y, Shimizu H, Iga JI, Ueno SI
- KMID: 2464726
- Clin Psychopharmacol Neurosci.
- 2019 Nov;17(4):559-563.
- doi: 10.9758/cpn.2019.17.4.559
Schizophrenic patients resistant to antipsychotics are diagnosed as having treatment-refractory schizophrenia, and they are treated with clozapine. However, clozapine is sometimes combined with electroconvulsive therapy (ECT) if clozapine monotherapy fails.... -
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- Aripiprazole-induced Hepatitis: A Case Report
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Castanheira L, Fernandes , Levy P, Coentre R
- KMID: 2464724
- Clin Psychopharmacol Neurosci.
- 2019 Nov;17(4):551-555.
- doi: 10.9758/cpn.2019.17.4.551
Aripiprazole is an atypical antipsychotic that acts as a partial agonist of dopamine type 2 receptors as well as 5-HT1A receptors. It is used in the treatment of schizophrenia and... -
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- Pharmacological Treatment in Parkinson's Disease
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Lee JJ
- KMID: 2464136
- J Korean Neurol Assoc.
- 2019 Nov;37(4):335-344.
- doi: 10.17340/jkna.2019.4.1
Parkinson's disease is one of the most common neurodegenerative disorders world widely. Although curable therapies are practically not available yet, symptomatic managements using anti-Parkinson medications have shown to be quite... -
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- Role of Helix 8 in Dopamine Receptor Signaling
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Yang HS, Sun N, Zhao X, Kim HR, Park HJ, Kim KM, Chung KY
- KMID: 2462878
- Biomol Ther.
- 2019 Nov;27(6):514-521.
- doi: 10.4062/biomolther.2019.026
G protein-coupled receptors (GPCRs) are membrane receptors whose agonist-induced dynamic conformational changes trigger heterotrimeric G protein activation, followed by GRK-mediated phosphorylation and arrestin-mediated desensitization. Cytosolic regions of GPCRs have been... -
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- Combination of In Vivo [¹²³I]FP-CIT SPECT and Microdialysis Reveals an Antipsychotic Drug Haloperidol-induced Synaptic Dopamine Availability in the Rat Midbrain and Striatum
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Park SH, Song YS, Moon BS, Lee BC, Park HS, Kim SE
- KMID: 2463715
- Exp Neurobiol.
- 2019 Oct;28(5):602-611.
- doi: 10.5607/en.2019.28.5.602
Synaptic dopamine (DA) is mainly regulated by the presynaptic DA transporter (DAT). Single-photon emission computerized tomography (SPECT) with the DAT radiotracer [¹²³I]FP-CIT assesses changes in synaptic DA availability when endogenous... -
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- Modulation of Dopaminergic Neuronal Excitability by Zinc through the Regulation of Calcium-related Channels
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Noh J, Chung JM
- KMID: 2463713
- Exp Neurobiol.
- 2019 Oct;28(5):578-592.
- doi: 10.5607/en.2019.28.5.578
Depending on the intracellular buffering of calcium by chelation, zinc has the following two apparent effects on neuronal excitability: enhancement or reduction. Zinc increased tonic activity in the depolarized state... -
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- Intrafamilial variability and clinical heterogeneity in a family with PLA2G6-associated neurodegeneration
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Park JK, Youn J, Cho JW
- KMID: 2465835
- Precis Future Med.
- 2019 Sep;3(3):135-138.
- doi: 10.23838/pfm.2019.00086
Phospholipase A2 group VI (PLA2G6)-associated neurodegeneration (PLAN) is an autosomal recessive neurodegenerative disease with a wide clinical spectrum; however, the genotype-phenotype correlation is unknown. Here, we report different phenotypes in... -
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- The Impact of Impulsivity on Quality of Life in Early Drug-Naïve Parkinson's Disease Patients
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Ryu DW, Kim JS, Yoo SW, Oh YS, Lee KS
- KMID: 2464635
- J Mov Disord.
- 2019 Sep;12(3):172-176.
- doi: 10.14802/jmd.19004
OBJECTIVE: Impulse control disorders (ICDs) in Parkinson's disease (PD) are mostly related to dopamine replacement therapy (DRT); however, drug-naïve PD patients have also frequently experienced impulsivity. This phenomenon makes clinicians... -
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- Methylphenidate and Central Precocious Puberty: A Probable Side Effect among Seven Children with the Attention Deficit Hyperactivity Disorder
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Ergür AT, Gül H, Gül A
- KMID: 2457410
- Clin Psychopharmacol Neurosci.
- 2019 Aug;17(3):446-449.
- doi: 10.9758/cpn.2019.17.3.446
Methylphenidate (MPH) is the most preferred drug for treatment of the attention deficit hyperactivity disorder (ADHD). Here, we aimed to discuss the possible effects and mechanisms of MPH on precocious... -
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- Long-term Effects of Aripiprazole Treatment during Adolescence on Cognitive Function and Dopamine D2 Receptor Expression in Neurodevelopmentally Normal Rats
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Choi HJ, Im SJ, Park HR, Park S, Kim CE, Ryu S
- KMID: 2457403
- Clin Psychopharmacol Neurosci.
- 2019 Aug;17(3):400-408.
- doi: 10.9758/cpn.2019.17.3.400
OBJECTIVE: This study aimed to investigate the long-term effects of aripiprazole treatment during adolescence on behavior, cognitive function, and dopamine D2 receptor (D2R) expression in adult rats. METHODS: Adolescent male Sprague-Dawley... -
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- Limonene Inhibits Methamphetamine-Induced Sensitizations via the Regulation of Dopamine Receptor Supersensitivity
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Gu SM, Kim SY, Lamichhane S, Hong JT, Yun J
- KMID: 2455090
- Biomol Ther.
- 2019 Jul;27(4):357-362.
- doi: 10.4062/biomolther.2018.213
Limonene is a cyclic terpene found in citrus essential oils and inhibits methamphetamine-induced locomotor activity. Drug dependence is a severe neuropsychiatric condition that depends in part on changes in neurotransmission... -
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- Restless Legs Syndrome in Parkinson's Disease Patients: Clinical Features Including Motor and Nonmotor Symptoms
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You S, Jeon SM, Do SY, Cho YW
- KMID: 2451115
- J Clin Neurol.
- 2019 Jul;15(3):321-327.
- doi: 10.3988/jcn.2019.15.3.321
BACKGROUND AND PURPOSE: We investigated the frequency and clinical features of restless legs syndrome (RLS) in patients with Parkinson's disease (PD). METHODS: This study included 74 PD patients. RLS was diagnosed... -
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- Early-Life Stress in D2 Heterozygous Mice Promotes Autistic-like Behaviors through the Downregulation of the BDNF-TrkB Pathway in the Dorsal Striatum
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Lee Y, Han PL
- KMID: 2451070
- Exp Neurobiol.
- 2019 Jun;28(3):337-351.
- doi: 10.5607/en.2019.28.3.337
A number of specific genetic variants including gene mutations and single nucleotide variations have been identified in genomewide association studies of autism spectrum disorder (ASD). ASD phenotypes in individuals carrying... -
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- Reduced Uptake on Dopamine Transporter Imaging by Methylphenidate
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Ha J, Ko J, Song JT, Hong JY
- KMID: 2454854
- J Korean Neurol Assoc.
- 2019 May;37(2):206-208.
- doi: 10.17340/jkna.2019.2.19
No abstract available. -
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- Effect of Delayed Elevation of Thyrotropin on Feeding Intolerance in Very Low Birth Weight Infants
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Hyun JK, Choi SY, Jung YJ, Lee JH
- KMID: 2451608
- Neonatal Med.
- 2019 May;26(2):102-110.
- doi: 10.5385/nm.2019.26.2.102
PURPOSE: We investigated the effect of delayed elevation of thyrotropin (TSH) (deTSH) on gastrointestinal motility in very low birth weight infants (VLBWI). METHODS: This study retrospectively investigated 228 premature VLBWI aged... -
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- Heterogeneous Patterns of Striatal Dopamine Loss in Patients with Young- versus Old-Onset Parkinson's Disease: Impact on Clinical Features
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Chung SJ, Yoo HS, Lee YH, Lee PH, Sohn YH
- KMID: 2449683
- J Mov Disord.
- 2019 May;12(2):113-119.
- doi: 10.14802/jmd.18064
OBJECTIVE: Ample evidence has suggested that age at onset of Parkinson's disease (PD) is associated with heterogeneous clinical features in individuals. We hypothesized that this may be attributed to different... -
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