J Korean Soc Biol Psychiatry.  2001 Jun;8(1):106-110.

The Association between the Dopamine D1 Receptor Genotype and Treatment Response in Korean Schizophrenic Patients

• Paik JW
• Lee MS
• Rhee CS
• Lim DJ
• Ham WH

Abstract

BACKGROUND: Dopamine receptors have been regarded as a strong candidate involved in etiology of schizophrenia and a target for various antipsychotic drugs. The purpose of our study was to investigate whether dopamine D1 receptor(DRD1) gene polymorphisms would predict the treatment response to antipsychotics in schizophrenia. METHOD: One hundred thirty-four schizophrenic patients, who met DSM-IV criteria for schizophrenia were entered into a 48-week study. The psychopathology of the patients was assessed at baseline, 12th, 24th, 48th weeks of treatment by PANSS. Responders were defined by a 20% of the reduction in total PAnSS score at end point. The genomic DNA fragment corresponding to nucleotides of dopamine D1 receptor gene was amplified by polymerase chain reaction(PCR). RESULT: Neither allelic frequencies nor genotypes for dopamine D1 receptor differed significantly between responders and non-responders. Also, there was no difference of changes of PANSS scores among three genotype groups of the dopamine D1 receptor.
CONCLUSION
Allelic variation in the dopamine D1 gene is not associated with individual differences in antipsychotic response.

MeSH Terms

Antipsychotic Agents
Diagnostic and Statistical Manual of Mental Disorders
DNA
Dopamine*
Genotype*
Humans
Individuality
Nucleotides
Psychopathology
Receptors, Dopamine
Receptors, Dopamine D1*
Schizophrenia
Antipsychotic Agents
DNA
Dopamine
Nucleotides
Receptors, Dopamine
Receptors, Dopamine D1