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Identification of Molecular Signatures in Mild Intrinsic Atopic Dermatitis by Bioinformatics Analysis

Yin H, Wang S, Gu C

BACKGROUND: Atopic dermatitis (AD) is recognized as a common inflammatory skin disease and frequently occurred in Asian and Black individuals. OBJECTIVE: Since the limitation of dataset associated with human severe AD,...
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Epigenetic Regulation of Filaggrin Gene Expression in Human Epidermal Keratinocytes

Lee J, Jang A, Seo SJ, Myung SC

BACKGROUND: Loss-of-function mutations in the filaggrin gene (FLG), which encodes an epidermal protein crucial for the formation of a functional skin barrier, have been identified as a major predisposing factor...
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LAMC1 is a prognostic factor and a potential therapeutic target in endometrial cancer

Kunitomi H, Kobayashi , Wu RC, Takeda T, Tominaga E, Banno K, Aoki D

OBJECTIVE: With the emerging significance of genetic profiles in the management of endometrial cancer, the identification of tumor-driving genes with prognostic value is a pressing need. The LAMC1 gene, encoding...
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Evaluation of Neo-Osteogenesis in Eosinophilic Chronic Rhinosinusitis Using a Nasal Polyp Murine Model

Khalmuratova R, Lee M, Park JW, Shin HW

PURPOSE: Osteitis refers to the development of new bone formation and remodeling of bone in chronic rhinosinusitis (CRS) patients; it is typically associated with eosinophilia, nasal polyps (NPs), and recalcitrant...
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Evogliptin, a Dipeptidyl Peptidase-4 Inhibitor, Attenuates Renal Fibrosis Caused by Unilateral Ureteral Obstruction in Mice

Kim MJ, Kim NY, Jung YA, Lee S, Jung GS, Kim JG, Lee IK, Lee S, Choi YK, Park KG

Renal fibrosis is considered to be the final common outcome of chronic kidney disease. Dipeptidyl peptidase-4 (DPP-4) inhibitors have demonstrated protective effects against diabetic kidney disease. However, the anti-fibrotic effect...
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Matrix Metallopeptidase 3 Polymorphisms: Emerging genetic Markers in Human Breast Cancer Metastasis

Suhaimi SA, Chan SC, Rosli R

Matrix metallopeptidase 3 or MMP3, is a zinc-dependent proteolytic enzyme that is involved in various physiological processes via modification of the extracellular matrix. In particular, its over-expression has been associated...
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Involvement of the TNF-α Pathway in TKI Resistance and Suggestion of TNFR1 as a Predictive Biomarker for TKI Responsiveness in Clear Cell Renal Cell Carcinoma

Hwang HS, Park YY, Shin SJ, Go H, Park JM, Yoon SY, Lee JL, Cho YM

BACKGROUND: Mechanism and predictive biomarkers for tyrosine kinase inhibitor (TKI) resistance of advanced clear cell renal cell carcinoma (ccRCC) have not been fully evaluated. METHODS: We performed gene expression profiling on...
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NOTCH1 Pathway is Involved in Polyhexamethylene Guanidine-Induced Humidifier Disinfectant Lung Injuries

Lee E, Kang MJ, Kim JH, Lee SH, Lee SY, Cho HJ, Yoon J, Jung S, Park Y, Oh DK, Hong SB, Hong SJ

An outbreak of fatal humidifier disinfectant lung injuries (HDLI) occurred in Korea. Human studies on mechanisms underlying HDLI have yet to be conducted. This study aimed to investigate methylation changes...
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Select Macrophage Noncoding RNAs of Interest in Cardiovascular Disease

Enchill Z, Lantz C, Thorp EB

Cardiovascular disease remains a leading cause of morbidity and mortality worldwide. Aspects of disease severity that are associated with heightened inflammation, such as during atherosclerosis or after myocardial infarction, are...
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Positioning Metabolism as a Central Player in the Diabetic Heart

Mereweather LJ, Montes Aparicio CN, Heather LC

In type 2 diabetes (T2D), the leading cause of death is cardiovascular complications. One mechanism contributing to cardiac pathogenesis is alterations in metabolism, with the diabetic heart exhibiting increased fatty...
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mTOR-coordinated Post-Transcriptional Gene Regulations: from Fundamental to Pathogenic Insights

Yeh HS, Yong J

Post-transcriptional regulations of mRNA transcripts such as alternative splicing and alternative polyadenylation can affect the expression of genes without changing the transcript levels. Recent studies have demonstrated that these post-transcriptional...
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Restoration of the inflammatory gene expression by horse oil in DNCB-treated mice skin

Lee JC, Park GR, Choi BS, Lee Y, Han CH

The present study evaluated the anti-inflammatory effect of horse oil in 2, 4-dinitrochlorobenzene (DNCB)-treated BALB/c mice. After the application of DNCB, the mice showed atopic dermatitis symptoms, including severe erythema,...
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Interaction of genetic background and exercise training intensity on endothelial function in mouse aorta

Kim SK, Avila JJ, Massett MP

The purpose of this study was to characterize the genetic contribution to endothelial adaptation to exercise training. Vasoreactivity was assessed in aortas from four inbred mouse strains (129S1, B6, NON,...
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MicroRNAs in Asthma and Respiratory Infections: Identifying Common Pathways

Taka S, Tzani-Tzanopoulou P, Wanstall H, Papadopoulos NG

MicroRNAs (miRs) are single-stranded RNAs of 18-25 nucleotides. These molecules regulate gene expression at the post-transcriptional level; several of these are differentially expressed in asthma as well as in viral...
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Combined biomarker for prediction of response to an immune checkpoint inhibitor in metastatic gastric cancer

Heo YJ, Kang SY, Kim ST, Kang WK, Lee J, Kim KM

PURPOSE: Immune checkpoint blockades (ICB) have been successful in gastric cancer (GC). However, the majority of unselected patients with GC fail to respond to ICB. It is crucial to identify...
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Arginine methylation as a key post-translational modification in skeletal muscle homeostasis: a review

Kim H, Kang JS, Jeong HJ

Arginine methylation mediated by protein arginine methyltransferases (PRMTs) has emerged as a key post-translational modification of histone or nonhistone substrates. It involves or controls signaling pathways or gene expression implicated...
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Effects of Bamboo Salt with Sodium Fluoride on the Prevention of Dental Caries

Lee HJ, Park AR, Oh HN

BACKGROUND: Dental caries is one of several prevalent oral diseases caused by dental plaque biofilms. This study evaluated the anti-cariogenic effects of a bamboo salt (BS) and sodium fluoride (NaF)...
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Three-Dimensional Analysis of Mouse Habenula Subnuclei Reveals Reduced Volume and Gene Expression in the Lipopolysaccharide-mediated Depression Model

Yang E, Kim JY, Yang SH, Lee E, Sun W, Lee HW, Kim H

The habenula (Hb) is small but important brain structure, anatomically and functionally links the forebrain with the midbrain to modulate various neuropsychiatric functions associated with drug addiction and emotion-associated dysfunctions....
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HisCoM-PAGE: software for hierarchical structural component models for pathway analysis of gene expression data

Mok L, Park T

To identify pathways associated with survival phenotypes using gene expression data, we recently proposed the hierarchical structural component model for pathway analysis of gene expression data (HisCoM-PAGE) method. The HisCoM-PAGE...
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DNA methylation: a cause and consequence of type 2 diabetes

Kim M

DNA methylation is a relatively stable epigenetic modification that can regulate and stabilize gene expression patterns and hence establish cell identity. Because metabolic intermediates are key factors of DNA methylation...
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