Genomics Inform.  2019 Dec;17(4):e45. 10.5808/GI.2019.17.4.e45.

HisCoM-PAGE: software for hierarchical structural component models for pathway analysis of gene expression data

Affiliations
  • 1Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul 08826, Korea. tspark@stats.snu.ac.kr
  • 2Department of Statistics, Seoul National University, Seoul 08826, Korea.

Abstract

To identify pathways associated with survival phenotypes using gene expression data, we recently proposed the hierarchical structural component model for pathway analysis of gene expression data (HisCoM-PAGE) method. The HisCoM-PAGE software can consider hierarchical structural relationships between genes and pathways and analyze multiple pathways simultaneously. It can be applied to various types of gene expression data, such as microarray data or RNA sequencing data. We expect that the HisCoM-PAGE software will make our method more easily accessible to researchers who want to perform pathway analysis for survival times.

Keyword

gene expression; hierarchical component model; pathway analysis; survival phenotype

MeSH Terms

Gene Expression*
Methods
Phenotype
Sequence Analysis, RNA
Full Text Links
  • GNI
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr