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Fever Associated with Clozapine Administration: Incidence, Clinical Characteristics, and Related Factors

Nam HJ, Jeon HO, Yoon SC, Lee D, Hong KS

  • KMID: 2286839
  • Korean J Psychopharmacol.
  • 2005 May;16(3):234-239.
OBJECTIVE: This study aims at investigating the incidence, clinical nature and associated clinical characteristics of the clozapine-induced fever. METHODS: Retrospective review of hospital records was performed for 56 inpatients who...
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A Case of Convulsive Seizure Development Induced by Clozapine

Seo MK, Kim DK, Kim EY

  • KMID: 2334602
  • J Korean Soc Biol Psychiatry.
  • 1999 Jul;6(1):135-141.
The authors described a case of male schizophrenia who developed myoclonic jerk repeatedly and one episode of convulsive seizure during the treatment of clozapine. According to literatures and reported cases,...
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A Case of Clozapine Treatment of Parkinsonism with Delusional Disorder

Seo JS, Chung SK

  • KMID: 1554995
  • Korean J Psychopharmacol.
  • 1997 Oct;8(2):261-266.
We experienced clinical improvement by clozapine(mean maintenance dosage: 100mg/day) and antiparkinsonian medication in 68-year-old man, diagnosed both secondary parkinsonism and delusional disorder. This result supports previous reports that clozapine may...
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Oxybutynin Hydrochloride in 3 Cases of Clozapine Induced Nocturnal Enuresis

Chee IS, Park CB, Lee SW, Wang SK, Shin SC

  • KMID: 2340495
  • J Korean Neuropsychiatr Assoc.
  • 2000 Sep;39(5):955-959.
Nocturnal enuresis has been recognized as an adverse effect of clozapine treatment. We reported 3 chronic schizophrenic patients who had showed nocturnal enuresis following clozapine treatment. Oxybutynin hydrochloride on clozapine-induced...
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Dilated Cardiomyopathy Associated with Clozapine

Roh S, Ahn DH, Kim YS, Lee BH

  • KMID: 2341073
  • J Korean Neuropsychiatr Assoc.
  • 2005 Jan;44(1):125-128.
Clozapine is an atypical antipsychotic agent that is more effective than the typical neuroleptics in the treatment of refractory schizophrenia. However, clozapine is also a drug associated with potentially serious...
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Eosinophilia, Pleural Effusion, Hepatitis, and Jaundice Occurring Early in Clozapine Treatment

Kang SH, Lee JI

  • KMID: 2171168
  • Clin Psychopharmacol Neurosci.
  • 2013 Aug;11(2):103-105.
Clozapine use is associated with various adverse events, some of which have received little attention, including eosinophilia, pleural effusion, and hepatitis. Because of the fatality of jaundice with hepatitis, it...
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The Efficacy and Safety of Concurrent Administration of Clozapine and Electroconvulsive Therapy: A Case Report

Kim CE, Lee SY

  • KMID: 2071114
  • Korean J Psychopharmacol.
  • 2000 Mar;11(1):73-77.
To assess the efficacy and safety of combining electroconvulsive therapy(ECT) and clozapine in patients with treatment-resistant schizophrenia, the authors reviewed use of this combination in one treatment-resistant schizophrenic inpatient and...
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Successful Early Clozapine Trial in the Treatment of First-episode Schizophrenia: A Case Report

Kim YJ, No SH, Lee SY

  • KMID: 2171152
  • Clin Psychopharmacol Neurosci.
  • 2013 Dec;11(3):168-169.
Clozapine remains the treatment of choice in refractory schizophrenia despite its various requirement to prescribe, such as mandatory blood monitoring program and various metabolic complication. Currently, clozapine is recommended only...
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Clozapine-Induced Acute Hepatitis

Jang SJ, Yi HT, Paek JH, Lee SY

  • KMID: 2340279
  • J Korean Neuropsychiatr Assoc.
  • 1999 Jan;38(1):227-233.
The authors report two cases of clozapine-induced acute hepatitis. Two patients developed asymptomatic hepatitis and got better with conservative care. We decreased the dosage of clozapine and added hepatic protectors,...
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A Case with Profuse Diarrhea and Thrombocytopenia Following the Administration of Clozapine

Kim JH, Lee CU, Kim JJ, Kim WS, Paik IH

  • KMID: 2340068
  • J Korean Neuropsychiatr Assoc.
  • 1997 May;36(3):588-592.
The clozapine has been used to the treatment of schizophrenic patients unresponsive to conventional antipsychotics, but to administration of clozapine has been restricted because of its propensity to cause agranulocytosis....
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An Unusual Case of Delirium after Restarting Clozapine

Khanra S, Sethy RR, Munda SK, Khess CR

Clozapine is a gold standard medication and drug of choice in refractory schizophrenia. Among many of its fatal side effects, delirium is less reported and inconsistently recognized by clinicians. We...
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A Case of Clozapine-Induced Hypotension and Seizure in a Schizophrenic Patient with Tardive Dystonia

Kim IH, Park KH, Chung SK

  • KMID: 2071115
  • Korean J Psychopharmacol.
  • 2000 Mar;11(1):78-82.
We experienced clinical improvement of psychotic symptoms and tardive dystonia during clozapine therapy in a 24 year-old-schizophrenic woman who had received antipsychotics for 3.7 years. However, we experienced the side...
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A Case of Clozapine Treatment for Tardive Dystonia in Chronic Schizophrenia

Oh MS, Oh KS, Noh KS, Lee SH

  • KMID: 1554996
  • Korean J Psychopharmacol.
  • 1997 Oct;8(2):267-270.
Tardive dystonia is an uncommon late side-effect of neuroleptic drug treatment and a difficult condition to treat. We report a single case of tardive dystonia that has successfully responded to...
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Efficacy of Clozapine on Schizophrenia with Polydipsia: Two Cases Experience

Kim CE, Park NJ, Kang MH, Bae JN

  • KMID: 2287348
  • Korean J Psychopharmacol.
  • 2003 Mar;14(1):63-66.
Polydipsia occurs frequently in chronic schizophrenic patients, some of whom develop hyponatremia. Although the underlying pathophysiology of polydipsia among psychiatric patients, recent reports indicate that clozapine treatment improves polydipsia-hyponatremia in...
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Pericarditis with Pericardial Effusion and Bilateral Pleural Effusion Associated with Clozapine Treatment in an Adolescent Boy

Jung SH, Kim WH, Choi HJ, Lee MJ, Kang MH, Kim CE, Bae JN, Lee JS

  • KMID: 1471861
  • Korean J Psychopharmacol.
  • 2009 May;20(3):141-146.
The clozapine has been associated with serious side-effects, such as agranulocytosis and seizure. Less attention has been given to clozapine's adverse cardiac complications, including myocarditis, pericarditis and cardiomyopathy despite a...
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Clonidine Treatment of Clozapine-Induced Hypersalivation

Lee HK, Park IJ, Kwon YJ, Jeong HY

  • KMID: 2334636
  • J Korean Soc Biol Psychiatry.
  • 2000 Jul;7(1):80-84.
BACKGROUND: Hypersalivation can be a troublesome side effect of clozapine, limiting its usefulness in the management some cases of schizophrenia. But the pharmacodynamic basis of clozapine-induced hypersalivation remains obscure. Object...
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A Case of Clozapine-Induced Anemia and Thrombocytosis

Jeon SY, Park H

Clozapine is a well-known antipsychotic which causes hematologic adverse effects, specifically neutropenia and agranulocytosis (1-3% of patients). However, reports on blood dyscrasias like anemia and thrombocytosis after clozapine treatment are...
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Combined Clozapine and Electroconvulsive Therapy in a Japanese Schizophrenia Patient: A Case Report

Yoshino Y, Ozaki Y, Kawasoe K, Ochi S, Niiya T, Sonobe N, Matsumoto , Ueno SI

  • KMID: 2279949
  • Clin Psychopharmacol Neurosci.
  • 2014 Aug;12(2):160-162.
Clozapine is well-known for successful use in schizophrenic patients treatment resistant to other antipsychotics. However, even with clozapine, 25% of schizophrenic patients are not in remission. Recently, as adjunctive treatment...
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Clinical Predictors of Clozapine Response in Schizophrenics

Kim JH, Suh YD, Park SH, Chung YI

  • KMID: 2340184
  • J Korean Neuropsychiatr Assoc.
  • 1998 Jul;37(4):711-718.
The identification of clinical predictors of clozapine response in schizophrenics might be helpful to make a selection of the patients for clozapine treaolent, and could also be useful to diminish...
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A Case of Eosinophilia Induced by Clozapine

Kim SY, Kim JJ, Lee CU, Paik IH

  • KMID: 2340153
  • J Korean Neuropsychiatr Assoc.
  • 1998 Mar;37(2):381-385.
Clozapine, one of the dibenzodiazepine derivatives, has potent antipsychotic properties and acts on schizophrenic patients who are nonresponsive to classic neuroleptics without neurologic side effects such as extrapyamidal symptoms, tardive...
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