J Korean Neuropsychiatr Assoc.
1997 May;36(3):588-592.
A Case with Profuse Diarrhea and Thrombocytopenia Following the Administration of Clozapine
- Affiliations
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- 1Department of Psychiatry, College of Medicine, Catholic University of Korea, Seoul, Korea.
Abstract
- The clozapine has been used to the treatment of schizophrenic patients unresponsive to conventional antipsychotics, but to administration of clozapine has been restricted because of its propensity to cause agranulocytosis. So side effects associated with the administration of clozapine have probably not been fully elucidated. The authors describe a case of a male schizophrenic who developed profuse diarrhea, spiking fever and thrombocytopenia associated with the administration of clozapine. Discontinuance of clozapine therapy resulted in improvement of diarrhea and fever followed by normalization of the platelet count. Previous report of adverse hematologic side effects and gastroenteric reaction induced by clozapine administration are also discussed. We suggest that the physician must keep in mind these side effects and administer dozapine cautiously.
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